Platelet interactions with calcium-phosphate-coated surfaces

Kikuchi, Lena; Park, Jun Yong; Victor, Charles; Davies, John E.

doi:10.1016/j.biomaterials.2005.01.009

Cited by 93 publications

(92 citation statements)

References 42 publications

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“…In (Park et al, 2001;Kikuchi et al, 2005). This alteration of platelet concentration was expected, since H c was precisely chosen in such a way that such an increase took place when the implant surface microtopography, i.e.…”

Section: Resultsmentioning

confidence: 98%

“…These growth factors have been shown to stimulate the migration and proliferation of bone marrow derived-cells as well as the proliferation of human osteoblasts (Linkhart et al, 1996;Dimitriou et al, 2005;Kark et al, 2006). Note that an increase in the implant surface microtopography with an appropriate surface roughness can enhance protein adsorption, promoting platelet adhesion and activation, eventually leading to an acceleration of the global healing process (Park et al, 2001;Kikuchi et al, 2005). At the same time, a fibrin network is formed through the well known process of hemostasis.…”

Section: Brief Biological Overview Of Peri-implant Bone Healingmentioning

confidence: 99%

“…The "taxis" parameter H c was determined by means of numerical simulations so that a 4-fold increase in the concentration of platelets at the surface of the implant was obtained when the microtopography was changed from low to high, which is in the range of the experimental observations (Park et al, 2001;Kikuchi et al, 2005). This procedure led to a value of 0.333 mm 4 /(day µg) for H c .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Bone ingrowth on the surface of endosseous implants. Part 1: Mathematical model

Moreo

García-Aznar

Doblaré

2009

Journal of Theoretical Biology

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Section: Resultsmentioning

confidence: 98%

Section: Brief Biological Overview Of Peri-implant Bone Healingmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Bone ingrowth on the surface of endosseous implants. Part 1: Mathematical model

Moreo

García-Aznar

Doblaré

2009

Journal of Theoretical Biology

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“…An exhaustive range of cells and their reactions to microtopography have been studied [12][13][14]. When looking specifically at platelets, it has been shown that surface topography in the micron range can modulate their activation, in terms of adhesion, generation of platelet microparticles (PMP) and P-selectin expression [15][16][17]. In recent years much attention has been paid to nanotopography when designing biologically inspired materials.…”

Section: Introductionmentioning

confidence: 99%

Influence of nanoporesize on platelet adhesion and activation

Ferraz

Carlsson

Hong

et al. 2008

J Mater Sci: Mater Med

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In this study we have evaluated the influence of biomaterial nano-topography on platelet adhesion and activation. Nano-porous alumina membranes with pore diameters of 20 and 200 nm were incubated with whole blood and platelet rich plasma. Platelet number, adhesion and activation were determined by using a coulter hematology analyzer, scanning electron microscopy, immunocytochemical staining in combination with light microscopy and by enzyme immunoassay. Special attention was paid to cell morphology, microparticle generation, Pselectin expression and b-TG production. Very few platelets were found on the 200 nm alumina as compared to the 20 nm membrane. The platelets found on the 20 nm membrane showed signs of activation such as spread morphology and protruding filipodia as well as P-selectin expression. However no microparticles were detected on this surface. Despite the fact that very few platelets were found on the 200 nm alumina in contrast to the 20 nm membrane many microparticles were detected on this surface. Interestingly, all microparticles were found inside circular shaped areas of approximately 3 lm in diameter. Since this is the approximate size of a platelet we speculate that this is evidence of transient, non-adherent platelet contact with the surface, which has triggered platelet microparticle generation. To the authors knowledge, this is the first study that demonstrates how nanotexture can influence platelet microparticle generation. The study highlights the importance of understanding molecular and cellular events on nano-level when designing new biomaterials.

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“…Die direkt nach erfolgter Implantatinsertion objektivierbare Primärstabilität ist eine Funktion aus mechanischer Knochenqualität, Implantat-(schrauben-)geometrie und Eindrehmoment [20,21] [11,15,19,23]. So findet sich auf rauen (z.B.…”

Section: Phasen Der Implantateinheilungunclassified