Platelet–lymphocyte ratio as a potential prognostic factor in gynecologic cancers: a meta-analysis

Jiang, Shanshan; Liu, Jiandong; Chen, Xiangyi; Zheng, Xinfei; Ruan, Junhao; Ye, Aihua; Zhang, Shufang; Zhang, Lingli; Kuang, Zhixing; Liu, Rongqiang

doi:10.1007/s00404-019-05257-y

Cited by 18 publications

(20 citation statements)

References 58 publications

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“…When considering the function and role of these blood cells in the systemic inflammation, immune system, and progression or suppression of malignancies, the prognostic importance of these cells in HCC can also be predicted. Moreover, several studies have been performed to determine the correlation between prognoses and relative proportions of each cell type, including NLR, PLR, and LMR [27][28][29][30] , which suggest a significant difference in recurrence and survival based on the proportion of each blood cell type, despite administering different treatment modalities in patients with HCC [9][10][11] . However, studies focusing on prognostic importance of absolute count itself of each cell type are rarely conducted, except for few studying lymphopenia and thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma

Park

Yoo

et al. 2021

Sci Rep

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Although several studies have confirmed the clinical significance of the systemic inflammation markers in hepatocellular carcinoma (HCC), evaluating the clinical significance of each blood cell remains to be conducted. We aimed to evaluate the clinical importance of absolute counts of blood cells in the overall survival (OS) of patients with newly diagnosed HCC. We recruited patient cohorts from the prospective registry of newly diagnosed and previously untreated HCC at Samsung Medical Center, which included a training set of 6619 patients (2005–2013) and a validation set of 2084 patients (2014–2016). More than three-quarters of all patients had hepatitis B virus (HBV)-related HCC in both training and validation sets. The optimal cutoff values of the absolute counts of neutrophils, lymphocytes, monocytes, and platelets were 3917, 488, 1379, and 22,100, respectively, which correlated significantly with OS. The absolute blood cell counts categorized by each optimal cutoff value significantly correlated with liver function status determined by Child–Pugh class/albumin-bilirubin (ALBI) grade and the HCC burden determined by several staging systems/portal vein tumor thrombosis. Although the prognostic model based on these blood cells (ABC model) showed a lower prognostic ability than the Japan Integrated Staging or ALBI-T staging systems, it provided significant discrimination of survival in the subgroups of ALBI-T and showed the highest prognostic ability in the present study in the training and validation sets. Absolute counts of blood cells are independently associated with OS, though it is also significantly associated with liver function and tumor burden in newly diagnosed HCC.

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Section: Discussionmentioning

confidence: 99%

Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma

Park

Yoo

et al. 2021

Sci Rep

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“…A recent meta-analysis including 28 studies with 15,617 patients indicated that an elevated PLR was associated with poor OS of patients with gastric cancer (44). Another meta-analysis also revealed that the pretreatment PLR was a simple, promising prognostic indicator of OS and PFS of patients with ovarian and cervical cancers (45). Furthermore, a high PLR was associated with poor prognosis in patients with nasopharyngeal carcinoma (46).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of the Platelet-to-Lymphocyte Ratio in Patients With Melanoma: A Meta-Analysis

Zhang

Gong

2020

Front. Oncol.

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Background: The prognostic role of the platelet-to-lymphocyte ratio (PLR) is controversial in patients with melanoma. Therefore, we performed a meta-analysis to assess the prognostic value of the PLR in patients with melanoma. Methods: PubMed, Web of Science, Embase, Cochrane library, WanFang, and China National Knowledge Infrastructure were searched for eligible studies. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the association between the PLR and overall survival (OS) and progression-free survival (PFS). Results: Nine studies with 2,396 patients were included in this meta-analysis. A high PLR was a predictor of shorter OS (HR = 1.67, 95% CI = 1.18-2.38, p = 0.004), but not PFS (HR = 1.53, 95% CI = 0.96-2.44, p = 0.075) in patients with melanoma. Subgroup analysis revealed that the PLR remained a significant prognostic indicator of both OS and PFS in patients with non-metastatic disease; the PLR cutoff value of <120 had a consistent prognostic value. Conclusions: An increased PLR was associated with poor OS of patients with melanoma. Hence, we suggest that the preoperative PLR could be used to identify high-risk patients and provide information regarding the prognosis of patients with melanoma.

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“…Inflammation is a main crucial hallmark of malignancies and is involved in various tumors, including cervical cancer. 6,7 Research on inflammation and inflammatory mediators has revealed that inflammation markers can trigger a premetastatic niche to escape the immunological surveillance and to play decisive roles at every step of tumorigenesis and development. 8 These inflammatory molecules-such as neutrophils, 9 platelets, 10 lymphocytes, 11 fibrinogen (Fib), 12 albumin (Alb), 13 and combinations of several single markers in the forms of ratios, 14,15 which are usually derived from circulating immune cells and acute-phase reactive proteins-have been reported as valuable predictors in a variety of human tumors.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Albumin to Fibrinogen Ratio in Cervical Cancer

Huang

Zhang

et al. 2020

Int J Biol Markers

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Background: Albumin to fibrinogen ratio (AFR) play a crucial role in the progression and prognosis of many malignant tumors. This study aimed to comprehensively assess the diagnostic value of AFR as single markers or in combination with squamous cell carcinoma antigen (SCC-Ag), cancer antigen 125 (CA-125) in cervical cancer. Methods: A total of 323 cervical cancer inpatients, 143 patients with cervical intraepithelial neoplasia (CIN) and 317 healthy controls were analyzed. Differences in laboratory parameters and clinicopathological features were calculated using the Mann–Whitney U or Kruskal–Wallis H test. The receiver operating characteristic (ROC) curve was used to evaluate the predicted value of AFR, alone or combined with SCC-Ag, CA-125 for the diagnosis of cervical cancer. Results: The levels of AFR in patients with cervical cancer were significantly lower than those in the CIN patients and the control subjects. AFR were not only negatively correlated with the tumor stage, but also related to histology typing, lymph node metastasis, distant metastasis, depth of stromal infiltration, tumor size, and tumor stage; however, it was not associated with the blood group. AFR combined with SCC-Ag possessed a larger area under the curve (AUC; AUCAFR+SCC-Ag = 0.924, 95% confidence interval (CI) 0.900, 0.944) than AFR ( P < 0.001), SCC-Ag ( P < 0.001), or CA-125 ( P < 0.001) did alone. Conclusions: The pretreatment levels of AFR, alone or combined with SCC-Ag, CA-125 could improve the diagnostic efficiency of cervical cancer.

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Platelet–lymphocyte ratio as a potential prognostic factor in gynecologic cancers: a meta-analysis

Cited by 18 publications

References 58 publications

Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma

Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma

Prognostic Value of the Platelet-to-Lymphocyte Ratio in Patients With Melanoma: A Meta-Analysis

Diagnostic Value of Albumin to Fibrinogen Ratio in Cervical Cancer

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