Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy

Chen, Mingzhu; Wang, Ping; Jiang, Dean; Bao, Zhirong; Hong, Quan

doi:10.3389/fonc.2021.793006

Cited by 10 publications

(7 citation statements)

References 35 publications

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“…Cellular uptake is an important basis for nanodelivery drugs. Studies have revealed that platelet membranes potentiate drug-carrying particles the ability to be taken up by tumors and to target tumor cells [ 19 , 20 ]. We further investigated the interactivity between PLTM - coated nanoparticles and hepatocellular carcinoma cells.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of growth of hepatocellular carcinoma by co-delivery of anti-PD-1 antibody and sorafenib using biomimetic nano-platelets

Da,

Cao,

et al. 2024

BMC Cancer

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Background Traditional nanodrug delivery systems have some limitations, such as eliciting immune responses and inaccuracy in targeting tumor microenvironments. Materials and methods Targeted drugs (Sorafenib, Sora) nanometers (hollow mesoporous silicon, HMSN) were designed, and then coated with platelet membranes to form aPD-1-PLTM-HMSNs@Sora to enhance the precision of drug delivery systems to the tumor microenvironment, so that more effective immunotherapy was achieved. Results These biomimetic nanoparticles were validated to have the same abilities as platelet membranes (PLTM), including evading the immune system. The successful coating of HMSNs@Sora with PLTM was corroborated by transmission electron microscopy (TEM), western blot and confocal laser microscopy. The affinity of aPD-1-PLTM-HMSNs@Sora to tumor cells was stronger than that of HMSNs@Sora. After drug-loaded particles were intravenously injected into hepatocellular carcinoma model mice, they were demonstrated to not only directly activate toxic T cells, but also increase the triggering release of Sora. The combination of targeted therapy and immunotherapy was found to be of gratifying antineoplastic function on inhibiting primary tumor growth. Conclusions The aPD-1-PLTM-HMSNs@Sora nanocarriers that co-delivery of aPD-1 and Sorafenib integrates unique biomimetic properties and excellent targeting performance, and provides a neoteric idea for drug delivery of personalized therapy for primary hepatocellular carcinoma (HCC).

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Section: Resultsmentioning

confidence: 99%

Inhibition of growth of hepatocellular carcinoma by co-delivery of anti-PD-1 antibody and sorafenib using biomimetic nano-platelets

Da,

Cao,

et al. 2024

BMC Cancer

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“…This is very important. Although many nanomaterials have good killing effect on tumors, they also have corresponding physiological toxicity, which limits their long-term biological and clinical value [36]. The treatment schedule is shown in Figure 5(c).…”

Section: Colony Formation Assay Also Demonstrated Consistent Results ...mentioning

confidence: 99%

Cancer Cell Membrane Biomimetic Mesoporous Nanozyme System with Efficient ROS Generation for Antitumor Chemoresistance

Tang

Lyu

et al. 2022

Oxidative Medicine and Cellular Longevity

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Single-atom nanozymes (SAZs) with reaction specificity and optimized catalytic properties have great application prospects in tumor therapy. But the complex tumor microenvironment (low content of H2O2) limits its therapeutic effect. In this study, we developed a bionic mesoporous Fe SAZs/DDP nanosystem (CSD) for enhanced nanocatalytic therapy (NCT)/chemotherapy by simultaneously encapsulating the chemotherapeutic drugs cisplatin (DDP) and Fe SAZs with high peroxidase (POD) activity into the cancer cell membrane. CSD could evade immune recognition and actively targets tumor sites, and DDP upregulates endogenous H2O2 levels by activating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, thereby enhancing SAZs-mediated hydroxyl radical (·OH) production, which subsequently leads to mitochondrial damage and intolerance to chemotherapy drug. We used the HGC27/DDP cell line for in vitro and in vivo experiments. The results showed that CSD achieved good therapeutic benefits, without any side effects such as inflammatory reaction. This system can induce multiple antitumor effect with H2O2 self-supply, mitochondrial damage, and ATP downregulation and eventually lead to chemosensitization.

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“…Therefore, the RT sensitizer based on platelet membrane was developed to achieve enhanced RT results. 54 Leukocytes Membrane. Immune cells are leukocytes, which play a vital role as "patrol soldiers" in the human immune system.…”

Section: ■ Cells Membrane Coatingmentioning

confidence: 99%

“…PCA with the capacity of targeting and radiosensitization enables nanodrugs to overcome renal effects and escape immune elimination. Therefore, the RT sensitizer based on platelet membrane was developed to achieve enhanced RT results …”

Section: Cells Membrane Coatingmentioning

confidence: 99%

Surface Membrane Coating as a Versatile Platform for Modifying Antitumor Nanoparticles

Wang

et al. 2022

ACS Materials Lett.

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Antitumor nanoparticles now confront several obstacles, including poor biocompatibility and biodegradability, quick removal, and a short cycle time, given the growing interest in surface membrane coating as a versatile platform for altering nanoparticles and overcoming the limitations of current nanodrug delivery methods. This paper reviews the recent progress of cells, synthetic polymers, polyphenols, and polysaccharides membrane coatings with favorable biocompatibility and biodegradability and easy surface modification on the surface of antitumor nanoparticle platforms, which can provide a promising strategy for endowing nanoparticles with specific and expected performance to optimize the efficiency of antitumor. Furthermore, multiple membrane combination strategies and additional biorecognition ligands modification on the membrane surface are supplied in an attempt to tackle the challenges of single membrane coating in a variety of tumor therapeutic applications and ultimately facilitate effective clinical transformation.

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Platelet Membranes Coated Gold Nanocages for Tumor Targeted Drug Delivery and Amplificated Low-Dose Radiotherapy

Cited by 10 publications

References 35 publications

Inhibition of growth of hepatocellular carcinoma by co-delivery of anti-PD-1 antibody and sorafenib using biomimetic nano-platelets

Inhibition of growth of hepatocellular carcinoma by co-delivery of anti-PD-1 antibody and sorafenib using biomimetic nano-platelets

Cancer Cell Membrane Biomimetic Mesoporous Nanozyme System with Efficient ROS Generation for Antitumor Chemoresistance

Surface Membrane Coating as a Versatile Platform for Modifying Antitumor Nanoparticles

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