Platelet Monoamine Oxidase Activity Correlates with Social Affiliative and Agonistic Behaviors in Normal Rhesus Monkeys

Redmond, Eugene; Murphy, Dennis L.; Baulu, J.

doi:10.1097/00006842-197903000-00002

Cited by 75 publications

(14 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical correlates of high platelet M A 0 activity (anxiety, 13; depression, secondary to anxiety, 9; schizophrenia-related depression, 10; and paranoia, 14) seem consistent with the personality correlates in the present study. In line with these findings are results on monkeys with high platelet M A 0 activity who showed a strong tendency to social isolation (51). Of interest are also recent neuropsychological findings from our group (52), suggesting a reversal of cerebral asymmetries in high M A 0 subjects.…”

Section: Discussionsupporting

confidence: 85%

Markers for vulnerability to psychopathology: Temperament traits associated with platelet MAO activity

Schalling

Åsberg

Edman

et al. 1987

Acta Psychiatr Scand

405

241

View full text Add to dashboard Cite

The functional linkage between platelet MAO activity and psychopathology was explored by analyzing temperamental correlates in 40 male subjects by means of scales from the Eysenck Personality Questionnaire (EPQ), the Zuckerman Sensation Seeking Inventory, and the Karolinska Scales of Personality (KSP). Linear correlations were found with two sensation seeking scales, replicating earlier findings. However, nonlinear correlations predominated. Subjects with intermediate platelet MAO activity had higher scores in conformity scales and lower scores in anxiety and hostility scales than low and high MAO subgroups. Low MAO subjects showed a pattern of higher scores in KSP Impulsiveness, EPQ Neuroticism, and KSP Somatic Anxiety and Irritability and lower scores in KSP Socialization, in line with personality profiles found in alcoholics, psychopaths, and suicide attempters who also tend to have low platelet MAO activity. High MAO subjects scored lower in sensation seeking and conformity scales and higher in KSP Psychasthenia, Muscular Tension and Suspicion scales, consistent with clinical links between high platelet MAO activity and anxiety and paranoia.

show abstract

Section: Discussionsupporting

confidence: 85%

Markers for vulnerability to psychopathology: Temperament traits associated with platelet MAO activity

Schalling

Åsberg

Edman

et al. 1987

Acta Psychiatr Scand

405

241

View full text Add to dashboard Cite

show abstract

“…MAO-B is under complete genetic determination and a gene has been found underlying the enzyme. Comparative correlational results from an MAO study of monkeys observed in a colony living in a natural island environment parallel many of the human personality and behavioral results (Redmond, Murphy, & Baulu, 1979). Low MAO monkeys of both sexes were more active and social and spent more time in play than high MAO monkeys.…”

Section: Monoamine Oxidasementioning

confidence: 60%

Personality and Risk‐Taking: Common Bisocial Factors

Zuckerman

Kuhlman

2000

Journal of Personality

980

624

View full text Add to dashboard Cite

The first part of this article describes a study of the relationships between personality and risk-taking in six areas: smoking, drinking, drugs, sex, driving, and gambling. The participants, 260 college students, were given self-report measures of risky behaviors in each of the six areas and the Zuckerman-Kuhlman five-factor personality questionnaire. Generalized risk-taking (across all six areas) was related to scales for impulsive sensation seeking, aggression, and sociability, but not to scales for neuroticism or activity. Gender differences on risk-taking were mediated by differences on impulsive sensation seeking. The second part discusses biological traits associated with both risk-taking and personality, particularly sensation seeking, such as the D4 dopamine receptor gene. the enzyme monoamine oxidase, and augmenting or reducing of the cortical evoked potential. Comparative studies show relationships between biological markers shared with other species and correlated behaviors similar to sensation seeking in humans. A biosocial model of the traits underlying risk-taking is presented.

show abstract

“…8,9 In studies on non-human primates, associations between trbc MAO and behavior were reported, which, in essence, confirmed the findings in humans. 10 Those early studies on rhesus monkeys have recently been nicely confirmed and considerably extended. 11 Other support for a connection between the enzyme and CNS function stems from the report by Sostek et al 12 that trbc MAO activity is related to the behavior in new-born babies such as screaming and motor activity as well as their consolability.…”

Section: Thrombocyte Monoamine Oxidase As a Biological Markermentioning

confidence: 87%

Genetic mechanisms of behavior—don't forget about the transcription factors

et al. 2001

View full text Add to dashboard Cite

Major changes in psychiatric phenotypes due to genetic factors are seldom the result of single gene polymorphisms, but more often the result of several genetic mechanisms. In this millennium article we discuss the notion that the expression of numerous candidate genes could be regulated by the same transcription factors, and that polymorphisms in transcription factor genes might explain some phenotypes. We describe recent results of studies on the biological marker thrombocyte monoamine oxidase (trbc MAO) and the transcription factor AP-2␤. Low levels of trbc MAO is associated with temperamental characteristics such as sensation seeking and impulsiveness, and the enzyme is genetically regulated by specific transcriptional mechanisms. Transcription factor AP-2␤ is important for the development of midbrain structures and AP-2␤ has several binding sites in the regulatory regions of genes encoding key proteins in the monoamine transmitter systems. We have recently shown AP-2␤ to be linked to personality, binge-eating disorder, treatment with antidepressant drugs, and also to trbc MAO. Regardless of whether transcriptions factors, such as AP-2␤, regulate the expression of eg, the number of monoamine neurons or a variety of candidate genes within the monoamine systems, or both, we would like to emphasize the role of transcription factors, besides polymorphisms in monoaminergic candidate genes, when explaining inter-individual differences in temperament and psychiatric vulnerability. Molecular Psychiatry (2001) 6, 503-510.

show abstract

Platelet Monoamine Oxidase Activity Correlates with Social Affiliative and Agonistic Behaviors in Normal Rhesus Monkeys

Cited by 75 publications

References 47 publications

Markers for vulnerability to psychopathology: Temperament traits associated with platelet MAO activity

Markers for vulnerability to psychopathology: Temperament traits associated with platelet MAO activity

Personality and Risk‐Taking: Common Bisocial Factors

Genetic mechanisms of behavior—don't forget about the transcription factors

Contact Info

Product

Resources

About