Platelet‐poor plasma gel vs platelet‐rich plasma for infraorbital rejuvenation: A clinical and dermoscopic comparative study

Abstract

Infraorbital dark circles and tear trough deformity are considered common aesthetic problems. Numerous therapeutic modalities have been suggested with variable outcomes. The aim of this study was to compare the efficacy of platelet-poor plasma (PPP) gel vs platelet-rich plasma (PRP) in infraorbital rejuvenation. A total of 68 females presented with dark circles and/or tear trough deformity were recruited and treated by PPP gel injection in the right infraorbital region (Group A) and PRP injection in the left infraorbital region (Group B). They received three treatment sessions at 2-week interval, and followed up monthly for 3 months. They were evaluated clinically and dermoscopically before treatment and at the end of follow-up period. Both groups showed significant clinical improvements proved by significant reduction of degree of hyperpigmentation and tear trough rating scale. Obviously, more significant clinical and dermoscopic improvements were observed in Group A than Group B. Therefore, it could be concluded that both PPP gel and PRP were clinically effective procedures for aesthetic improvement of infraorbital region. Moreover, PPP gel seems to be significantly more effective than PRP as a therapeutic modality.

Comparison of the Effects of Repeated Applications of Platelet-Rich Plasma versus Platelet-Poor Plasma on Fat Graft Survival in Nude Mice

“…Previous studies have demonstrated positive effects of PRP, supporting its clinical use. In contrast, platelet-poor plasma (PPP) has a lower concentration of platelets than PRP [19,20]. Zhang et al [21] confirmed that PPP maintained the phenotype of osteoblastic cells and enhanced the rate of MSC proliferation.…”

Efficacy of platelet‐poor plasma gel in combination with fractional CO2 laser in striae distensae: A clinical, histological, and immunohistochemical study

“…In addition, the direct volumetric filling effect of plasma gel increased skin tone and volume with more glowing appearance. 4,15 Furthermore, the increased time interval between the sessions in the present work, up to 6 weeks, allowed PIH to be greatly reduced, thus giving better outcome at the end of the treatment sessions.…”

“…They explained their results by increased fibrinogen concentration in plasma gel more than PRP, in addition to the more likely arrangement of fibrin fibers in bundles creating insoluble net functioning as a scaffold trapping platelets in the injection site. This confirms continued release of their growth factors to enhance tissue restoration and collagen remodeling 4,15. Consequently, F I G U R E 3 A 47-year-old female patient, Fitzpatrick's type III, presented with; (A) striae albae on abdomen since 15 years, (B) Grade 3 improvement (50%-74%…”

“…1,2 Multiple studies 10-14 recommended fractional CO 2 laser either alone or combined with other therapeutic modalities for SD. Recently, platelet-poor plasma gel has been suggested as bio-filler for facial rejuvenation 4,15 and scar treatment. 5,6 Up to our knowledge, no previous study evaluated the therapeutic efficacy of intradermal injection of plasma gel combined with fractional CO 2 laser in SD.…”

Quantifiable clinical efficacy of injectable porcine collagen for the treatment of structural dark circles

“…There are three kinds of filling materials commonly used in the clinic: autologous filling materials, biological agents, and artificial filling materials. Although the autologous filling materials and biological agents, such as stromal vascular fraction gel (SVF‐gel), microfat graft, platelet‐rich plasma, and acellular dermal matrix, have proven to be effective in tear trough deformity treatment and have no immunogenicity and allergenicity, 11‐14 they also have many limitations and defects. First, the preparation of these self‐materials and biological agents not only has strict requirements for equipment and participant, but also often faces ethical disputes.…”