Platelet Radioligand Binding and Neuroendocrine Challenge Tests in Depression

Current views on the organisation and functions of the circadian rhythm system are outlined. Evidence is presented supportive of the notion that the pathophysiology of the affective disorders involves a disruption of circadian rhythms and that the primary locus of action of agents effective in the affective disorders is on the circadian rhythm system. Potential disruptions of this system are enumerated. Such a hypothesis, it is argued, might potentially unite the disparate neurochemical and neuroendocrinological findings emerging in both depression and mania. There are in addition neuropsychological and nosological implications of such a framework, which may help bridge the divide between molecular and behavioural approaches to research on the affective disorders which are outlined.

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Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders

Healy

1987

Psychopharmacology

112

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Challenge tests: Assessment of the noradrenergic and gaba systems in depression and anxiety disorders

Coupland

Glue

Nutt

1992

Molecular Aspects of Medicine

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Platelet 3H-imipramine binding sites in depressed patients and healthy controls: a comparison between morning and afternoon samples

Gentsch

Lichtsteiner

Gastpar³

et al. 1989

Journal of Affective Disorders

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Platelet Radioligand Binding and Neuroendocrine Challenge Tests in Depression

Cited by 10 publications

References 29 publications

Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders

Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders

Challenge tests: Assessment of the noradrenergic and gaba systems in depression and anxiety disorders

Platelet 3H-imipramine binding sites in depressed patients and healthy controls: a comparison between morning and afternoon samples

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