Platelet-rich autoplasma use at early stages of wound healing to prevent pathological scar development

Abstract

2 Городская клиническая больница № 2, Ставрополь, Российская Федерация 3 пятигорский межрайонный онкологический диспансер, Российская Федерация 4 первый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский университет), Российская Федерация 5 Дальневосточный государственный медицинский университет, Хабаровск, Российская ФедерацияPathological excess scar treatment is currently viewed as one of the most urgent issues with no single standard solution. We investigated the effectiveness of platelet-rich autoplasma use to stimulate wound healing. Seventy-six patients were assigned to two equivalent groups: control and main. The dynamics revealed a high efficiency of the plasma autostimulation method, which reduced the time of inpatient treatment, accelerated healing with a decrease in the effects of inflammation in the area of injury, stabilized angiogenesis, fibroplasia, and epithelialization, and, as a consequence, decreased the developmental rate of a pathological scar.

Evaluating the effectiveness of glucocorticosteroid monotherapy for the treatment of keloid and hypertrophic scars

“…Overexpression of cyclooxygenase type 1 (COX-1) is observed in hypertrophic scars, while cyclooxygenase type 2 (COX-2) is observed in keloids. It is known that a large number of pigments (melanin) present in the skin are predictors of keloid formation [16,17]. When injected into tissue, TA suppresses leukocyte and macrophage function, restricting leukocyte migration into the inflammatory node, impairs the ability of macrophages to produce interleukin-1; suppresses fibroblast and collagen formation; inhibits the activity of A2 phospholipase resulting in inhibition of prostaglandin and leukotriene synthesis.…”

Strategy for scar-prevention healing of traumatic and burns wounds

“…However, advanced medical techniques have proven highly effective and widely applicable due to pathogenic feasibility and safety [6,7]. PRPA is one of many ways to affect the process [8,9].…”