Platelet-rich-fibrin: A novel root coverage approach

Abstract

Treatment of gingival recession has become an important therapeutic issue due to increasing cosmetic demand. Multiple surgical procedures have been developed to obtain predictable esthetic root coverage. More specifically, after periodontal regenerative surgery, the aim is to achieve complete wound healing and regeneration of the periodontal unit. A recent innovation in dentistry is the preparation and use of platelet-rich plasma (PRP), a concentrated suspension of the growth factors, found in platelets. These growth factors are involved in wound healing and postulated as promoters of tissue regeneration. This paper reports the use of PRF membrane for root coverage on the labial surfaces of the mandibular anterior teeth. This was accomplished using laterally displaced flap technique with platelet rich fibrin (PRF) membrane at the recipient site.

Platelet Rich Fibrin: A Novel Approach for Osseous Regeneration

“…Combining the growth factors has been shown to accelerate bone repair and promote fibroblast proliferation, and increase tissue vascularity, rate of collagen formation, mitosis of mesenchymal stem cells and endothelial cells, as well as osteoblasts, playing key roles in the rate and extent of bone formation. This activity, together with increased vessel ingrowth, is mediated by PDGF and TGF [12]. Its chief advantages include ease of preparation and lack of biochemical handling of blood which makes this preparation strictly autologous.…”

Role of Platelet Rich Fibrin in Healing of Extraction Socket

“…5 Combining the growth factors has been shown to accelerate bone repair and promote fibroblast proliferation, and increase tissue vascularity, rate of collagen formation, mitosis of mesenchymal stem cells and endothelial cells, as well as osteoblasts, playing key roles in the rate and extent of bone formation. 4 PRF is in the form of a platelet gel and can be used in conjunction with bone grafts, which promotes wound healing, bone growth and maturation, graft stabilization, wound sealing and hemostasis and improves the handling properties of graft materials. PRF can also be used as a membrane.…”

“…Since then Chokroun's PRF has found clinical applications in bone reconstruction procedures (Mazor et al 2009), treating residual extraction sockets 3 and for root coverage in case of gingival recession. 4 In this randomized clinical trial, an attempt was made to evaluate the role of Platelet Rich Fibrin(PRF) in terms of healing and bone regeneration potential in extraction sockets and its comparison with the naturally healing extraction socket wound.…”

Vista technique and Platelet-Rich Fibrin Membrane for Treatment of Multiple Adjacent Gingival Recessions - 6 month follow-up.

“…What is also important is that the resulting from the patient clot contains no chemical or biological additives while it has a solid structure and can easily be used to prepare strong, elastic fibrin membrane. Many publications with promising results appeared in the past few years about the treatment of gingival recessions with PRF [6,[12][13][14][15] . In 2011 Zadeh H H [16] modified the tunnel technique offering the so-called VISTA (Vestibular Incision subperiosteal Tunnel Access) technique for the treatment of multiple adjacent gingival recessions in the front part of the maxilla.…”

“…This tissue is taken from the palate which greatly increases the difficulty and the probability of complications throughout the surgery and even afterwards [1] . In order to minimize these disadvantages, the method of GTR (guided tissue regeneration) [2] with biodegradable and non-biodegradable membranes and biologically active substances such as acellular dermal matrix allograft (ADM) [3] , enamel matrix derivate (EMD) [4] , platelet-rich plasma (PRP) [5] , platelet-rich fibrin (PRF) [6] and more. The platelet-rich fibrin (PRF) was first introduced for the first time by Choukroun et al in 2001 and is regarded as a second generation platelet concentrate.…”