Role of Platelet Rich Fibrin in Healing of Extraction Socket

Shrivastava, Amit Kumar; Shenoi, Ramakrishna; Garg, Anup; Vats, Vikas; Gadve, Vandana; Siddiqui, Afaque

doi:10.21276/ijcmr.2018.5.5.29

Cited by 5 publications

(12 citation statements)

References 5 publications

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“…The topmost PRF gel layer was retrieved from the test tube, squeezed on sterile saline-soaked gauze pieces to obtain the PRF membrane which was immediately placed in the extraction socket. 3,22 (Fig. 3)…”

Section: Prfmentioning

confidence: 99%

“…7 The exclusion criteria included patients with history of any relevant medical condition or chronic use of medications such as antihistamines, NSAID or steroids and antidepressants that may interfere with the subjective evaluation of their postoperative pain, history of platelet/ bleeding/ connective tissue disorders, patients on anticoagulants or immunosuppressant drugs, periodontally compromised patients, presence of pericoronitis, and those having deleterious habits (tobacco chewing, smokers and regular alcohol consumption), patients allergic toward ozone or penicillin or other drugs; status of pregnancy or lactation. 3,9 Fig. ( 3) PRF clot a.…”

Section: A-prfmentioning

confidence: 99%

“…1,2 Undisturbed tissue healing, proper wound care and control of post-operative pain and trismus were the main issues of many studies to improve the patients' quality of life after this surgical procedure. 3 Pharmacological therapy, alternative medicine, in addition to complementary protocols have been developed to control post-operative complications. Ozone therapy is considered as a modern, nonmedicated alternative strategy with demonstrated antibacterial and anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

“…The development of bioactive additives in surgery has evolved a great challenge in clinical research. 3 Platelet-rich fibrin (PRF) is one of the bioactive surgical additives that has become popular in tissue regeneration field. 7 PRF is derived by centrifugation of autologous blood without addition of any anticoagulants.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Ozone gel, PRF & A-PRF on Pain and Trismus during Tissue Healing after Extraction of Mandibular Third Molars

Yousef

Ateia

Mansour

et al. 2021

Egyptian Dental Journal

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Objective: This prospective study evaluated the impact of ozone gel, conventional PRF (C-PRF) and advanced PRF (A-PRF) on pain and trismus when applied after surgical extraction of impacted mandibular third molars. Materials and Methods:This study included 48 patients with impacted mandibular third molars. They were randomly divided into 4 groups, group I (control); didn't receive any material in the socket, group II: sockets received ozone gel, group III: sockets received PRF while in group IV: sockets received A-PRF. Pain assessment using VAS, analgesics consumption, and maximum mouth opening were evaluated on day 1, day 3 and day 7 follow-up.Results: Less values of VAS pain scores were recorded in group II in comparison with the control group on day 1, day 3 and day 7 with a statistically significant difference of (P=0.018), (P=0.044) and (P=0.015) respectively. The analgesics consumption showed a statistically significant difference in group II compared to group I (P=0.020) and (P=0.021) on day 1 and day 3 respectively, but day 7 was statistically insignificant (P=0.165). Maximum mouth opening was statistically significant (P=0.042) on day3 in group II when compared with group I. Conclusion:The present study shows that ozone gel can be of paramount importance in minimizing post-operative symptoms as regard to pain and trismus following the extraction of impacted mandibular third molars and appears to improve patient's relief and quality of life after surgery.

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Section: Prfmentioning

confidence: 99%

Section: A-prfmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Ozone gel, PRF & A-PRF on Pain and Trismus during Tissue Healing after Extraction of Mandibular Third Molars

Yousef

Ateia

Mansour

et al. 2021

Egyptian Dental Journal

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“…This is in agreement with, Neiva et al 2009 (29) who evaluated the socket healing after 1 and 2 week and stated that its enough to observe healing of the socket. However this is in disagreement with Shrivastava et al 2018 who found that evaluation of complete bone healing reqiure around 4 and 6 weeks intervals (30).…”

Section: Discussionmentioning

confidence: 76%

Scannining Electron Microscopic Evaluation of the Effect of Boron and Fish Oil on Healing of Extraction Sockets in Rats

AbdElfatah

Samad

Koura

et al. 2020

Alexandria Dental Journal

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INTRODUCTION: Great incidence of complications have been reported tooth extraction. Many materials and drugs were used previously to cover extraction socket in an attempt to enhance healing or prevent post-operative complications. Several studies suggested that Boron and fish oil affect many of the biological processes during bone healing by influencing cell membrane function. Thus, they affect cellular responses to cytokines and hormones, including those involved in bone growth and turnover in rats. OBJECTIVE: of the study: To evaluate the effect of boron and fish oil on alveolar bone healing after tooth extraction in rats using Scanning Electron Microscope, Energy Dispersive x-ray analysis [EDXA] and serum alkaline phosphatase analysis. MATERIALS AND METHODS: forty-five adult male albino rats (120-150 gm in weight) were used in this study. Extraction of the lower 1 st molar was performed in all animals then they were randomly divided into 3 equal groups; Group I (control) including 15 rats fed on normal diet, Group II (boron) including 15 rats receiving normal diet and boron supplementation (3 mg/kg boron diluted in 3.5 ± 4 ml distilled water) daily, Group III (fish oil) including 15 rats receiving normal diet and fish oil supplementation (65 mg/kg fish oil) daily. The animals were sacrificed after 2 weeks and the effect of boron and fish oil was evaluated using Scanning Electron Microscope, Energy Dispersive x-ray analysis and Serum alkaline phosphatase level analysis. The data obtained was tabulated and subjected to statistical analysis. RESULTS: After 2 weeks of extraction, scanning Electron Microscopic results revealed an increase in trabecular bone thickness with regular bone surface, and uniform osteocyte lacunae in Group II (boron) in comparison to group I (control) and Group III (fish oil) and these results were proved by EDXA which showed increase in Ca level in group II than group I and group III. On the other hand, serum alkaline phosphatase analysis showed that group III (fish oil) has the higher level of ALP after 2 weeks of the experiment. CONCLUSION: Boron and fish oil systemic administration have a positive effect on socket healing and bone structure and composition in rats.

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Effect of using tri-calcium phosphate combined with platelet rich fibrin versus platelet rich plasma in post extraction socket

Shabana¹,

mohaed

Feky

2023

Al-Azhar Journal of Dental Science

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Objectives: This study was designed to evaluate the effect of using tricalcium phosphate combined with platelet rich fibrin versus platelet rich plasma in post extraction socket clinically and radiographically at maxillary esthetic zone. Subject and methods: This study was conducted on 30 patient seeking extraction of at least one hopeless tooth, they distributed into 3 groups.10 patients for control group , 10 patients for test group (a) and 10 patients for test group (b). In control group the socket was left to heal spontaneously by clot formation. In test group (a) the socket was filled with beta-tricalcium phosphate as bone graft and platelet rich fibrin. In test group (b) the socket was filled with beta-tricalcium phosphate and platelet rich plasma. CBCT image was taken to compare the vertical, horizontal ridge dimension and bone density pre-operatively and 6 month post-operatively. Result: There was statistically non-significant difference regarding the vertical height, bone width, buccal plate thickness and bone density in both groups pre-operatively. But after 6 months post-operatively there was statistically significant difference regarding three groups in all parameters. The test group (a) that represented βTCP and PRF showed a lower percentage of a change than test group (b) that represented βTCP and PRR than control group. Conclusion: The use of PRF accelerates socket wound healing after tooth extraction as noticed by reducing vertical and horizontal bone loss and maintaining favorable bone density values after 6 months postoperatively.

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Role of Platelet Rich Fibrin in Healing of Extraction Socket

Cited by 5 publications

References 5 publications

Impact of Ozone gel, PRF & A-PRF on Pain and Trismus during Tissue Healing after Extraction of Mandibular Third Molars

Impact of Ozone gel, PRF & A-PRF on Pain and Trismus during Tissue Healing after Extraction of Mandibular Third Molars

Scannining Electron Microscopic Evaluation of the Effect of Boron and Fish Oil on Healing of Extraction Sockets in Rats

Effect of using tri-calcium phosphate combined with platelet rich fibrin versus platelet rich plasma in post extraction socket

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