Platelet Rich Fibrin: A Second‐Generation Platelet Concentrate

Choukroun, Joseph; Miron, Richard J.

doi:10.1002/9781119406792.ch1

Cited by 13 publications

(20 citation statements)

References 56 publications

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“…The resulting product contains cell types (platelets, leukocytes, red cells), an extracellular fibrin matrix, and an array of bioactive molecules (predominately growth factors). 15 Depending on the blood collection tube and centrifugation protocol used, solid gel and liquid forms of PRF can be developed. Solid PRF, produced using glass tubes has been successfully used in oral and maxillofacial surgery, with beneficial effects on bone and soft tissue regeneration, infection control, and patient satisfaction.…”

Section: Introductionmentioning

confidence: 99%

“…It is obtained using a one‐step centrifugation process without the use of anticoagulants and thereby totally autologous. The resulting product contains cell types (platelets, leukocytes, red cells), an extracellular fibrin matrix, and an array of bioactive molecules (predominately growth factors) 15 . Depending on the blood collection tube and centrifugation protocol used, solid gel and liquid forms of PRF can be developed.…”

Section: Introductionmentioning

confidence: 99%

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Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

Hassan

Quinlan

Ghanem

2020

J of Cosmetic Dermatology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

Hassan

Quinlan

Ghanem

2020

J of Cosmetic Dermatology

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“…He showed that the ability of stem cells to treat large alveolar cleft defects is safe. Our findings in the present study showed the best outcome in group C patients who were treated with tissue engineering technology combined with PRF method [1] as Choukran [15] who stated all the merits of the platelet-derived growth factors.…”

Section: Discussionmentioning

confidence: 63%

“…PRP seems to enhance bone formation in alveolar clefts mixed with graft materials with less rate of postoperative complications. Its autologous, easy to prepare with a low cost that can be used as a source of growth factors [15], [16]. Orthodontic treatment has a major role in dental preparations preoperatively including maxillary expansion and teeth alignment allowing relief of crowding resulting from arch collapse and hypodontia it also creates space needed for the eruption of missing teeth as well as exposure of impacted teeth resulting from the cleft deformity.…”

Section: Introductionmentioning

confidence: 99%

Alveolar Cleft Reconstruction Using Different Grafting Techniques

Mossaad¹,

El-Badry²,

Abdelrahman³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Cleft lip and palate CLP is a frequent congenital malformation that manifests in several varieties including unilateral or bilateral anomalies due to either genetic or acquired causes. Alveolar cleft graft ACG remains controversial as regard timing, grafting materials and surgical techniques. The primary goal of alveolar cleft grafting in ACG patients is to provide an intact bony ridge at the cleft site to allow maxillary continuity for teeth eruption, proper orthodontic treatment for dental arch alignment, oronasal fistula closure and providing alar support for nasal symmetry. AIM: This study aims to compare different grafting techniques to treat the alveolar cleft defect. METHODS: This study included 24 cases divided into three groups of patients: Group A was treated with autogenous iliac crest bone; Group B was treated with nano calcium hydroxyapatite with collagen membrane and Group C was treated with tissue engineering method using bone marrow stem cells extract and PRF membrane. RESULTS: According to clinical and radiographic examination measuring bone density in the CT preoperatively compared to six months postoperatively. Group C with bone marrow stem cells extract showed superior results among all followed by group B, while group A with autogenous iliac crest showed resorption in some cases and gave the least values, in addition to its drawbacks as regard donor site affection with pain & scar formation. CONCLUSION: Bone substitutes as Nano calcium hydroxyapatite and bone marrow stem cells extract showed to be reliable methods for bone grafting than autogenous iliac crest.

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“…PRF is a fibrin clot rich in platelets that was first developed in France by Choukroun et al [18] for specific use in oral and maxillofacial surgery prepared from centrifuged blood. Fibrin is the activated form of plasmatic molecules called fibrinogen, the final substrate of all coagulation reactions [19,20].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of platelet-rich fibrin on alveolar bone height after removal of impacted lower third molar

Bagoury¹,

Hassan²,

Thabet³

2015

Egyptian Journal of Oral & Maxillofacial Surgery

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Objectives This study aimed to assess the effect of platelet-rich fibrin (PRF) on both bone and supporting tissue healing after surgical removal of impacted lower third molar using the digital panoramic bitewing technique.Patients and methods Twenty patients complaining of a bilaterally impacted lower third molar were included in the study. The surgical treatment plan was removal of bilaterally impacted lower third molar during the same visit under local anesthesia. For the study group, represented by the right side, PRF was prepared from the patient's blood and placed inside the socket and as a membrane covering the buccal bone as well as crestal bone distal to the lower second molar, whereas in the control group (left side of the same patient), nothing was applied at the surgical site and the flap was sutured in a regular manner on both sides. All patients were followed up clinically every week. A digital panoramic bitewing radiographic examination was performed preoperatively and then according to the following schedule: (a) immediately postoperatively (1 week), (b) 3 months, and (c) 6 months. ResultsThe study group showed statistically significant higher mean bone height and statistically significant lower mean pocket depth than the control group.Conclusion PRF is recommended for alveolar ridge preservation and shortening of the postoperative healing period after surgical removal of impacted lower third molar.

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Platelet Rich Fibrin: A Second‐Generation Platelet Concentrate

Cited by 13 publications

References 56 publications

Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

Alveolar Cleft Reconstruction Using Different Grafting Techniques

Evaluation of platelet-rich fibrin on alveolar bone height after removal of impacted lower third molar

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