Platelet‐rich fibrin and bovine porous bone mineral vs. platelet‐rich fibrin in the treatment of intrabony periodontal defects

Abstract

Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, Camargo PM. Platelet‐rich fibrin and bovine porous bone mineral vs. platelet‐rich fibrin in the treatment of intrabony periodontal defects. J Periodont Res 2012; 47: 409–417. © 2011 John Wiley & Sons A/S Background and Objective: Bovine porous bone mineral (BPBM) is a xenograft that has been successfully utilized in periodontal regeneration. Platelet‐rich fibrin (PRF) is a leukocyte and platelet preparation that concentrates various polypeptide growth factors and therefore has the potential to be used as regenerative treatment for periodontal defects. The purpose of this study was to examine the suitability of autologous PRF as regenerative treatment for periodontal intrabony defects in humans and to examine the ability of BPBM to augment the regenerative effects exerted by PRF. Material and Methods: Using a split‐mouth design, 17 paired intrabony defects were randomly treated either with PRF or with PRF–BPBM combination. Re‐entry surgeries were performed at 6 mo. Primary study outcomes were changes in pocket depth, attachment level and defect fill. Results: Preoperative pocket depths, attachment levels and transoperative bone measurements were similar for the PRF and PRF–BPBM groups. Postsurgical measurements revealed a significantly greater reduction in pocket depth in the PRF–BPBM group (4.47 ± 0.78 mm on buccal and 4.29 ± 0.82 mm on lingual sites) when compared with the PRF group (3.35 ± 0.68 mm on buccal and 3.24 ± 0.73 mm on lingual sites). The PRF–BPBM group presented with significantly greater attachment gain (3.82 ± 0.78 mm on buccal and 3.71 ± 0.75 mm on lingual sites) than the PRF group (2.24 ± 0.73 mm on buccal and 2.12 ± 0.68 mm on lingual sites). Defect fill was also greater in the PRF–BPBM group (4.06 ± 0.87 mm on buccal and 3.94 ± 0.73 mm on lingual sites) than in the PRF group (2.21 ± 0.68 mm on buccal and 2.06 ± 0.64 mm on lingual sites). Conclusion: The results of this study indicate that PRF can improve clinical parameters associated with human intrabony periodontal defects, and BPBM has the ability to augment the effects of PRF in reducing pocket depth, improving clinical attachment levels and promoting defect fill.

Comparative Evaluation of the Efficacy of Bioactive Ceramic Composite Granules Alone and in Combination with Platelet Rich Fibrin in the Treatment of Mandibular Class II Furcation Defects: A Clinical and Radiographic Study

“…Comparing with an arm of the study conducted by Pradeep AR et al, in which a combination of PRF and porous hydroxyapatite were used with OFD in mandibular Class II furcation defects [11], the mean reduction in PPD was 3.68±1.07 mm and mean relative vertical clinical attachment gain was 3.31±0.52 mm both being in accordance with the results of this study. In a study by Lekovic V et al, wherein the investigators combined bovine porous bone mineral and PRF and by Pradeep AR et al, wherein porous hydroxyapatite was combined with PRF in the management of intrabony defect a significant reduction in PPD and gain in clinical attachment level was observed from baseline [12,13]. This is in accordance with the results of this study though a direct comparison is debatable since defect morphology can influence the outcome of regenerative procedures.…”

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

“…8,9 PRF has been used in different surgical procedures such as sinus floor augmentation, treatment of gingival recession (GR), furcation defects, maxillary rehabilitation before implant placement, restoration of peri-implant defects, as well as healing of extraction sockets with promising results. 10,11,12,13,14 In addition, certain clinical studies have been conducted on the use of PRF for treatment of intra-bony defects in humans, 15,16,17,18,19 but none have investigated its additive effects with ABBM for treatment of intra-bony defects. Thus, the present split-mouth, single-centre, controlled study aimed to compare the healing of intra-bony defects treated with a combination of ABBM-PRF or ABBM alone; the hypothesis being tested was that PRF would augment the regenerative effects of ABBM in human intra-bony defects.…”

“…These results are in concordance with those of the aforementioned studies. 36,37 Several studies 15,16,17,38 have examined the suitability of autologous PRF for treatment of human intra-bony defects and revealed that PRF improves clinical 15 and radiographical 15,16,17,38 parameters. However, in the present study, no statistically significant differences were observed between both groups, except for the significant CAL gain noted in the test group.…”

Platelet-Rich Fibrin in the Treatment of Periodontal Bone Defects

“…9,10 Likewise, the efficiency of PRF was also proved when used in conjunction with other type of bone graft materials. 11 But, studies or reports combining both PRF and hydroxy apatite crystals are lacking. Since, hydroxy apatite is easily available and also cost effective; we used hydroxy apatite crystals in our study.…”