Platelet-Rich Fibrin in the Treatment of Periodontal Bone Defects

Abstract

Background: Periodontitis is characterized by the formation of true pockets, bone loss and attachment loss. Various techniques have been attempted in the past to truly regenerate the lost periodontal structures, albeit with variable outcome. In this evolution, the technique being tried out widely is the use of platelet rich concentrates, namely platelet-rich fibrin (PRF). Case description:In this report, we present a case of surgical treatment of osseous bone defects namely two walled crater and dehiscence treated in posterior teeth with autologously prepared platelet rich fibrin mixed with hydroxy apatite bone graft and PRF in the form of a membrane. Conclusion:Our results showed clinical improvements in all the clinical parameters postoperatively namely the pocket depth reduction and gain in attachment level and hence, PRF can be used alone or in combination with the bone graft to yield successful clinical results in treating periodontal osseous defects.Clinical significance: Platelet-rich fibrin is an effective alternative to platelet-rich plasma (PRP) in reconstructing bone defects.

Análisis estructural de la fibrina rica en plaquetas y sus aplicaciones en odontología regenerativa

“…Actualmente, el PRF se usa en diferentes tratamientos clínicos odontológicos como por ejemplo en cirugías maxilofaciales que requieren reconstrucciones óseas severas (16,17), en cirugías periodontales como alternativa al uso de injertos (18), en endodoncia para revitalización pulpar (19) y en apexificación de dientes inmaduros (20), entre otros. Aunque las aplicaciones clínicas son variadas, los reportes no describen con precisión la técnica, el tiempo post centrifugado, las condiciones de colocación del PRF, si se usa en membrana o gel, y en casos en que se requieren porciones muy pequeñas tampoco reportan el sitio o zona de donde se corta la membrana a usar.…”

New Resorbable Membrane Materials for Guided Bone Regeneration

“…PRF could easily be compressed into PRF membrane, by pressing the PRF clot between two pieces of surgical gauze [41,44]. PRF membrane has been successful in oral mucosal defects [44,46], periodontal bone defects [41,47], gingival recession defects [42], and tympanic membrane perforation [48]. PRF membrane offers acceptable elasticity and may stretch to some extent to cover wound edges, but it lacks rigidity and needs to be carefully handled to prevent tearing [41,44].…”

Effects of platelet‐rich fibrin on post‐extraction wound healing and wound pain: A meta‐analysis

“…Research has proved that PRF can effectively promote wound healing, bone regeneration, graft stabilisation and haemostasis 7,8 . In the clinical field of dentistry, PRF has also been widely used in dental clinics, including oral implantology, periodontology, maxillofacial surgery and mucosal diseases 9–12 . However, most of the applications in these fields are still based on the research reports on the ability of PRF to promote tissue repair and regeneration in combination with other materials, and there are few reports on the clinical studies on PRF alone as a material to promote the repair and regeneration of soft tissue defects 13 .…”

“… 7 , 8 In the clinical field of dentistry, PRF has also been widely used in dental clinics, including oral implantology, periodontology, maxillofacial surgery and mucosal diseases. 9 , 10 , 11 , 12 However, most of the applications in these fields are still based on the research reports on the ability of PRF to promote tissue repair and regeneration in combination with other materials, and there are few reports on the clinical studies on PRF alone as a material to promote the repair and regeneration of soft tissue defects. 13 Although there have been some studies on the use of PRF for healing and pain in extraction wounds compared with natural healing, the conclusions are not yet uniform.…”