Platelet‐rich plasma for treatment resistant frontal fibrosing alopecia: A case report

Özcan, Deren; Vural, Ayşe; Özen, Özlem

doi:10.1111/dth.13072

Cited by 18 publications

(17 citation statements)

References 12 publications

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“…There were no language restrictions. This article is based on previously conducted studies and does not contain any Cicatricial Lichen planopilaris Yes [47][48][49][50] Central centrifugal cicatricial alopecia Yes [47] Frontal fibrosing alopecia Yes [57] studies with human participants or animals performed by any of the authors.…”

Section: Methodsmentioning

confidence: 99%

“…Özcan et al [ 57 ] reported a clinical case of a patient diagnosed with FFA and 4 cm recession of the frontotemporal hairline, perifollicular erythema, scaling, and lichenoid papules on the frontal and temporal scalp. After failure of several conventional treatments and as a result of further recession of the frontotemporal hairline, absence of hair regrowth on the eyebrows, and persistence of clinical signs, the use of PRP was considered.…”

Section: Cicatricial Alopeciamentioning

confidence: 99%

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Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

Alves

Grimalt

2020

Dermatol Ther (Heidelb)

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The concept and description of platelet-rich plasma (PRP) started in the field of hematology and is being extensively used in other fields of medicine. Interest in the application of PRP has been increasing in dermatology, such as in tissue regeneration, wound healing, scar revision, skin-rejuvenating effects, and alopecia. PRP is an autologous blood product containing high concentrations of platelets in a small volume of plasma. Different preparations of PRP may lead to different volumes of PRP, platelet concentration, and presence or absence of leukocytes. PRP is being used as a new therapy for some types of non-cicatricial alopecia such as androgenetic alopecia (AGA) and alopecia areata (AA) and, recently, new insights refer to the possibility of action in the field of cicatricial alopecia, like lichen planopillaris (LPP) and frontal fibrosing alopecia (FFA). This article aims to identify the major indications for the application of PRP in the field of hair disorders, including non-cicatricial and cicatricial alopecia.

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Section: Methodsmentioning

confidence: 99%

Section: Cicatricial Alopeciamentioning

confidence: 99%

Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

Alves

Grimalt

2020

Dermatol Ther (Heidelb)

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“…70,71 Özcan and colleagues recently reported on using PRP for the treatment of resistant FFA. 72 Currently, there is not enough evidence to make recommendations on utilizing PRP for FFA treatment; however, we recommend using either three treatments, each separated by month duration and then annual or every 6-month follow-up treatment, or starting ongoing monthly therapies and reevaluating efficacy every 6 months. Consideration of cost and lack of efficacy data should be discussed with the patient.…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

<p>Optimal Management of Frontal Fibrosing Alopecia: A Practical Guide</p>

Imhof

Tolkachjov²

2020

CCID

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Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia that is often considered a clinical variant of lichen planopilaris (LPP) due to their shared histopathologic features. FFA is characterized by the recession of the frontal, temporal, or frontotemporal hairline; the clinical pattern is distinct and usually includes eyebrow hair loss, as well as other associated symptoms. Pruritus, facial papules, eyelash loss, body hair involvement, and trichodynia may also occur in addition to the frontotemporal recession and eyebrow loss classically seen. Early diagnosis and prompt treatment are critical as FFA is a progressive disorder that can result in permanent hair loss. FFA is challenging as patients may not present or be recognized until the disease has progressed. Additionally, there is currently no consensus or standard treatment regimen for FFA. While many different therapies have been reported as beneficial, there are a limited number of published guidelines for the treatment of FFA. This article is a review of the literature on treatment modalities for FFA and the objective is to offer a practical guide for clinicians on the evidence-based management options currently available in the literature.

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“…Frontal fibrosing alopecia (FFA) is an irreversible scarring cicatricial alopecia, manifesting as atrophic and band‐like recession of symmetric fronto‐temporal and fronto‐parietal hairline. FFA has been reported mainly in premenopausal women and rarely in men 1‐5 . It is considered a variant of lichen planopilaris (LPP) and is frequently associated with the presence of perifollicular erythema and scaling in the affected area.…”

Section: Introductionmentioning

confidence: 99%

“…FFA has been reported mainly in premenopausal women and rarely in men. [1][2][3][4][5] It is considered a variant of lichen planopilaris (LPP) and is frequently associated with the presence of perifollicular erythema and scaling in the affected area. The pathogenesis of FFA is poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Allergic contact dermatitis in patients with frontal fibrosing alopecia: An international multi‐center study

Rudnicka

Rokni

Lotti

et al. 2020

Dermatologic Therapy

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Frontal fibrosing alopecia (FFA) mainly affects the anterior hairline and eyebrows and its etiology and associated factors remain obscure. The aim of this study was to evaluate the allergic contact dermatitis with patch test in patients with FFA. In this prospective study, 20 patients with FFA and 24 age and sex‐matched healthy individuals were evaluated with patch testing. Diagnosis was made histologically, clinically and based on dermoscopic findings. Demographic data, age of onset, disease duration and FFA severity index are evaluated in all patients. Positive patch test reaction to one or more allergen was observed in 65% of patients while it was 37.5% in control group (P = .003). There was a significant difference between age (P = .006) and positive patch test results. No statistical significant difference was observed in the results of patch testing and disease duration (P = .519), menopausal status (P = .085), and FFA severity index (P = .573). Our findings suggest an association between FFA and allergic contact dermatitis. The utility of patch testing in FFA patients can explore the role of allergic etiology and may have an enormous impact on the diagnostic potential and quality of life of these patients.

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Platelet‐rich plasma for treatment resistant frontal fibrosing alopecia: A case report

Abstract: Frontal fibrosing alopecia (FFA) is a type of lymphocytic primary cicatricial alopecia characterized by receding frontotemporal hairline

Cited by 18 publications

References 12 publications

Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

<p>Optimal Management of Frontal Fibrosing Alopecia: A Practical Guide</p>

Allergic contact dermatitis in patients with frontal fibrosing alopecia: An international multi‐center study

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