PLATELET-RICH PLASMA (PRP) AND ITS APPLICATION IN THE TREATMENT OF CHRONIC AND HARD-TO-HEAL SKIN WOUNDS. A Review

The Effects of Tissue Healing Factors in Wound Repair Involving Absorbable Meshes: A Narrative Review

“…Chronic wounds are unresponsive to conventional treatment methods, are quite common, and pose a challenge to clinicians. A systematic review and meta-analysis of PRPtherapy-based in vitro and in vivo studies reported improved healing of partial or complete, chronic, recalcitrant wounds [133,134], a combination of PRP injections and platelet-derived patches improved healing in patients, especially those with diabetes [135], the topical application of autologous-PRP owing to its antimicrobial properties and tissue-regenerative potential is recommended [136], especially in cases where conventional therapy is not sufficient, or surgery is not possible, local immunity is activated; while the pain and risk of infections are reduced [137,138], it significantly enhanced the re-epithelization process [139], demonstrated a considerable enhancement in the formation of healthy granulation tissue and healing edge; lesser pain, slough, bleeding on touch, discharge, and no superficial or deep infections [140][141][142]. PRP alone or combined with a powdered bioengineered skin substitute was used to synthesize a platelet-rich tissue graft, reducing the wound size and depth [143].…”