Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP?

Marx, Robert E.

doi:10.1097/00008505-200110000-00002

Cited by 1,387 publications

(1,182 citation statements)

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“…After our processing, platelets reached a concentration of 1.7×10 12 /ml in a total of 7 ml plasma, which is 4.4 times the serum level. This concentration is comparable to the effective concentration of 1.0×10 12 /ml reported in the literature [18]. The specific growth factors in the PRP were not quantified in the present study, but the growth factors contained inside the porcine platelets have been reported in the literature [8,21].…”

Section: Discussionsupporting

confidence: 81%

Anterior lumbar interbody fusion with carbon fiber cage loaded with bioceramics and platelet-rich plasma. An experimental study on pigs

Zou

Xue

et al. 2004

Eur Spine J

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Section: Discussionsupporting

confidence: 81%

Anterior lumbar interbody fusion with carbon fiber cage loaded with bioceramics and platelet-rich plasma. An experimental study on pigs

Zou

Xue

et al. 2004

Eur Spine J

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“…Existem diversas formas de obtenção do PRP, dentre métodos manuais a automatizados, que refletem em composições diversas de fração proteica, leucócitos, hemácias e plaquetas (Kon et al 2013). As concentrações adequadas de plaquetas variam de oito vezes a concentração sanguínea basal até 200% a mais que a concentração sanguínea periférica (Marx 2001, Kon et al 2013. No PRP utilizado nesse trabalho foi desprezada a zona de névoa.…”

Section: Discussionunclassified

Arcabouço de PRP-gel associado a células tronco mesenquimais: uso em lesões condrais em modelo experimental equino

et al. 2016

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Resumo: O plasma rico em plaquetas (PRP) é conhecido por apresentar propriedades anabólicas, anti-inflamatórias e capacidade de gelificação. Atualmente o PRP é considerado eficaz na reparação da cartilagem, sendo sua capacidade de formação de gel indicada para o preenchimento de defeitos condrais. O objetivo desse estudo foi analisar o uso do PRP ativado, no formato de arcabouço, como suporte para o implante de células tronco mesenquimais (CTM), no preenchimento e tratamento de lesões condrais induzidas em equinos. Doze equinos foram submetidos a uma cirurgia artroscópica no tempo zero do experimento (T0), onde foi induzida uma lesão condral de 15 mm de diâmetro na tróclea medial femoral dos membros pélvicos direito. As 12 articulações foram divididas em dois grupos distintos com seis articulações cada (GA e GB). As articulações do GA foram submetidas ao tratamento com o implante de CTM em gel de PRP. As articulações de GB foram o grupo controle do experimento. As CTMs foram extraídas do tecido adiposo e o PRP em gel foi obtido por protocolo de dupla centrifugação seguido da adição de trombina liofilizada. Após cinco meses (T150) foi realizada nova artroscopia para avaliação macroscópica do local, coleta de amostras do tecido de reparação para análises de microscopia eletrônica, sendo realizadas imagens ressonância magnética e tomografia computadorizada no local do implante no GA. Observamos que o gel de PRP associado às CTM demonstrou ser adequado no tratamento de defeitos condrais experimentais dos equinos. GA evidenciou um melhor aspecto macroscópico e microscópico do tecido de reparação, sendo que GB mostrou maior desorganização das fibras colágenas. Nas imagens de ressonância magnética e tomografia computadorizada apenas foi relevante o local da lesão condral. O arcabouço de gel de PRP demonstrou ser apropriado no suporte do tratamento com as CTMs, sendo de fácil aplicação e efetivo, demonstrando resultados promissores na reparação de lesões condrais induzidas.

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“…In the analysis conducted in our study, the average platelet concentration was measured as 1,000,000 /mL. There are authors who claim that higher concentrations adversely affect wound healing 18 . Despite medical advances today, in cases with peritonitis -particularly fecal peritonitis-the risk of infections that might develop after closing up the abdomen and subsequent increased incisional hernia is still a major cause of morbidity, especially in emergency surgical procedures 19 .…”

Section: Discussionmentioning

confidence: 64%

Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis

et al. 2016

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PURPOSE:To evaluate the effects of platelet rich plasma (PRP) on the healing of fascia wherein peritonitis has been created. METHODS:Twenty eight Wistar Albino rats were divided into four groups. Only a primary fascial repair following laparotomy was performed on Group 1, a primary fascial repair performed and PRP treatment applied following laparotomy on Group 2, and a fecal peritonitis created following laparotomy and a primary fascial repair carried out on Group 3. A fecal peritonitis was created following laparotomy and primary fascial repair and PRP treatment on the fascia was carried out on Group 4. RESULTS:TNF-α was found to be significantly lower in the control group (Group 1). It was detected at the highest level in the group in which fecal peritonitis was created and PRP applied (Group 4). TGF-β was determined as being significantly higher only in Group 4. Histopathologically, the differences between the groups in terms of cell infiltration and collagen deposition were not found to be significant. CONCLUSION:When platelet rich plasma was given histologically and biochemicaly as wound healing parameters cellular infiltration, collagen accumulation, and tissue hydroxyiproline levels were not increased but neovascularization, fibroblast activation and TNF Alfa levels were increased and PRP accelerated wound healing.

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Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP?

Cited by 1,387 publications

References 0 publications

Anterior lumbar interbody fusion with carbon fiber cage loaded with bioceramics and platelet-rich plasma. An experimental study on pigs

Anterior lumbar interbody fusion with carbon fiber cage loaded with bioceramics and platelet-rich plasma. An experimental study on pigs

Arcabouço de PRP-gel associado a células tronco mesenquimais: uso em lesões condrais em modelo experimental equino

Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis

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