Platelet Satellitism as Presenting Finding in Mantle Cell Lymphoma

Abstract

Platelet satellitism surrounding polymorphonuclear neutrophils has been observed almost exclusively in EDTA-treated blood at room temperature. The mechanism underlying this phenomenon is not understood fully. We report a case of platelet rosetting around atypical lymphocytes in peripheral blood smears made from EDTA-treated and untreated blood. Flow cytometry of the peripheral blood sample and immunohistochemical stains of the subsequent bone marrow biopsy specimen revealed a monoclonal B-cell population positive for CD5, CD20, and cyclin D1 and negative for CD3 and CD23; cytogenetic findings revealed a complex karyotype that included t(11;14). These findings were consistent with mantle cell lymphoma. To our knowledge, the finding of platelet satellitism involving mantle cell lymphoma cells in peripheral blood has not been reported previously.

Peripheral blood lymphoagglutination and platelet satellitism in marginal zone lymphomas

“…We found a low frequency of platelet satellitism around lymphocytes (only one case, with a persisting phenomenon each time a blood smear was performed to that patient). To our knowledge, only three cases involving MZL cells have been described . Our unique case is consistent with the small number of cases described in the literature …”

Platelet satellitism and lympho‐agglutination as presenting finding in marginal zone B‐cell lymphoma

“…Our finding is, to the best of our knowledge, the first description of platelet satellitism described in marginal zone-B cell lymphoma. It has been reported around lymphoma cells in mantle cell lymphoma (Cesca, 2001). In these cases, a possible mechanism implies that monoclonal Ig secreted by lymphoma cells could recognise cryptogenic antigen on platelets.…”

Lymphocytic Platelet Satellitism

“…There have been previous reports of platelet satellitism around neoplastic lymphoid cells and large granular lymphocytes [2][3][4]. In our patient, small to medium-sized normal lymphocytes were involved in both platelet satellitism and possible emperipolesis.…”