Platelet serotonin and plasma prolactin and cortisol in healthy, depressed and schizophrenic women

Mück‐Šeler, Dorotea; Pivac, Nela; Mustapić, Maja; Crnčević, Željka; Jakovljević, Miro; Šagud, Marina

doi:10.1016/j.psychres.2004.04.001

Cited by 87 publications

(63 citation statements)

References 55 publications

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“…Although prolactin secretion is also activated by stress, previous studies have found no evidence that this hormone is elevated in antipsychotic-free patients (Muck-Seler et al, 2004;Rao et al, 1994;Segal et al, 2004;Warner et al, 2001). In fact, one recent study found elevated cortisol levels but normal prolactin levels in the same antipsychotic-free patients with schizophrenia (Muck-Seler et al, 2004). This further supports the notion that the increased pituitary volume in our antipsychotic-free subjects (and in those receiving atypicals) is due to activation of the HPA axis.…”

Section: Discussionsupporting

confidence: 80%

“…We now find that this phenomenon has a macroscopic brain correlate. Although prolactin secretion is also activated by stress, previous studies have found no evidence that this hormone is elevated in antipsychotic-free patients (Muck-Seler et al, 2004;Rao et al, 1994;Segal et al, 2004;Warner et al, 2001). In fact, one recent study found elevated cortisol levels but normal prolactin levels in the same antipsychotic-free patients with schizophrenia (Muck-Seler et al, 2004).…”

Section: Discussionmentioning

confidence: 96%

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Increased Pituitary Volume in Antipsychotic-Free and Antipsychotic-Treated Patients of the Æsop First-Onset Psychosis Study

Pariante

Dazzan

Danese

et al. 2005

Neuropsychopharmacol

142

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Subjects at their first psychotic episode show an enlarged volume of the pituitary gland, but whether this is due to hypothalamicpituitary-adrenal (HPA) axis hyperactivity, or to stimulation of the prolactin-secreting cells by antipsychotic treatment, is unclear. We measured pituitary volume, using 1.5-mm, coronal, 1.5 T, high-resolution MRI images, in 78 patients at the first psychotic episode and 78 age-and gender-matched healthy controls. In all, 18 patients were antipsychotic-free (12 of these were antipsychotic-naïve), 26 were receiving atypical antipsychotics, and 33 were receiving typical antipsychotics. As hypothesized, patients had a larger pituitary volume than controls ( þ 22%, po0.001). When divided by antipsychotic treatment, and compared to controls, the pituitary volume was 15% larger in antipsychotic-free patients (p ¼ 0.028), 17% larger in patients receiving atypicals (p ¼ 0.01), and 30% larger in patients receiving typicals (po0.001). Patients receiving typicals not only had the largest pituitary volume compared to controls but also showed a trend for a larger pituitary volume compared to the other patients grouped together ( þ 11%, p ¼ 0.08). When divided by diagnosis, and compared to controls, the pituitary volume was 24% larger in patients with schizophrenia/schizophreniform disorder (n ¼ 40, po0.001), 19% larger in depressed patients (n ¼ 13, p ¼ 0.022), 16% larger in bipolar patients (n ¼ 16, p ¼ 0.037), and 12% larger in those with other psychoses (n ¼ 9, p ¼ 0.2). In conclusion, the first-episode of a psychotic disorder is associated with a larger pituitary independently of the presence of antipsychotic treatment, and this could be due to activation of the HPA axis. Typical antipsychotics exert an additional enlarging effect on pituitary volume, likely to be related to activation of prolactin-secreting cells. This activation of the hormonal stress response could participate to the important metabolic abnormalities observed in patients with psychosis.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 96%

Increased Pituitary Volume in Antipsychotic-Free and Antipsychotic-Treated Patients of the Æsop First-Onset Psychosis Study

Pariante

Dazzan

Danese

et al. 2005

Neuropsychopharmacol

142

View full text Add to dashboard Cite

show abstract

“…No correlation between age and plasma cortisol levels was found in the present and previous studies (Muck-Seler et al, 1999;Seeman and Robbins, 1994). To avoid the possible influence of menstrual phases on the HPA activity (Leibenluft et al, 1994), patients were sampled in the follicular phase, and previously we have shown that pre-or post-menopausal status did not affect significantly plasma cortisol levels in schizophrenic patients (Muck-Seler et al, 2004).…”

Section: Discussioncontrasting

confidence: 56%

The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: A double blind study

Jakovljević

Pivac

Mihaljević-Peleš

et al. 2007

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Entre os artigos, o cortisol foi estudado em todos eles , seguido por ACTH 19,22,24,27,28,31,35,40 e prolactina 29,38 . O sulfato de dehidroepiandrosterona (DHEA-S) 32 e o CRH 36 só apareceram em um estudo cada.…”

Section: Métodosunclassified

“…O sulfato de dehidroepiandrosterona (DHEA-S) 32 e o CRH 36 só apareceram em um estudo cada. Na maior parte dos estudos, houve hiperatividade 18,20,[22][23][24][25]29,30,32,34,[42][43][44] ou a atividade do eixo HPA estava desregulada 21,27,28,31,35,37,[38][39][40][41] . Em poucos estudos, havia hipoatividade 19,26,36 do eixo ou não havia alteração 33 .…”

Section: Métodosunclassified

Avaliação do funcionamento do eixo HPA em deprimidos por meio de medidas basais: revisão sistemática da literatura e análise das metodologias utilizadas

Vilela

Juruena²

2014

J. bras. psiquiatr.

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rESUMo objetivo: Realizar revisão sistemática da literatura para conhecer a atividade do eixo hipotálamo-pituitária-adrenal (HPA) em deprimidos considerando-se as medidas basais dos hormônios e analisar criticamente as metodologias utilizadas. Métodos: Foi realizada busca de artigos nas bases de dados PubMed e SciELO. Na primeira base de dados, introduziram--se as palavras-chave "depressive disorder" e "HPA axis", e na segunda utilizaram-se os termos "depression" ou "depressão" e "HHA" ou "HPA axis". Optou-se por pesquisa realizada em humanos adultos, em inglês e português, do ano 2000 até 2011. resultados: Dos 27 artigos selecionados, obtiveram-se como resposta do eixo HPA tanto hiperatividade como atividade desregulada, hipoatividade ou não alteração. Tais resultados dependem das variáveis e dos hormônios estudados, do fluido coletado -plasma, urina, saliva, líquido cefalorraquidianodo horário de coleta, do número de coletas, da análise estatística utilizada, do subtipo de doença depressiva, entre outros. Conclusão: Os resultados não apresentam consenso em relação à atividade do eixo HPA. Considerando as variáveis estudadas, o eixo HPA, na maioria das vezes, apresenta-se disfuncional na presença da depressão. aBStraCt objective: We performed a systematic literature review in order to assess the hypothalamic--pituitary-adrenal (HPA) axis activity in depressed considering the baseline measurements of the hormones of this axis and perform a critical analysis of the methodologies used. Methods: We performed search for articles in the databases PubMed and SciELO. In the first database, was introduced the keywords: "depressive disorder", "HPA axis" and in the second used the terms "depression" or "depressão" and "HPA" or "HPA axis". We limit to research in adult

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Platelet serotonin and plasma prolactin and cortisol in healthy, depressed and schizophrenic women

Cited by 87 publications

References 55 publications

Increased Pituitary Volume in Antipsychotic-Free and Antipsychotic-Treated Patients of the Æsop First-Onset Psychosis Study

Increased Pituitary Volume in Antipsychotic-Free and Antipsychotic-Treated Patients of the Æsop First-Onset Psychosis Study

The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: A double blind study

Avaliação do funcionamento do eixo HPA em deprimidos por meio de medidas basais: revisão sistemática da literatura e análise das metodologias utilizadas

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