Platelet-to-Lymphocyte Ratio and Use of NSAIDs during the Perioperative Period as Prognostic Indicators in Patients with NSCLC Undergoing Surgery

Lee, Brenda M.; Rodriguez, Andrea C.; Mena, Gabriel E.; Gottumukkala, Vijaya; Mehran, Reza J.; Rice, David C.; Feng, Lei; Yu, Jun; Cata, Juan P.

doi:10.1177/107327481602300312

Cited by 27 publications

(18 citation statements)

References 34 publications

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“…Lee et al made a similar observation. Apart from preoperative values of the PLR ratio, exceeding 180 and stages II and III according to the TNM Classification of Malignant Tumours, also age, male sex and postoperative radiotherapy appeared to be independent, negative prognostic factors of OS (12). Similarly, Xu et al showed that PLR >135 constitutes an independent predictive factor for T category (13).…”

Section: Discussionmentioning

confidence: 93%

Prognostic value of neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratio ratios in patients operated on due to non-small cell lung cancer

et al. 2019

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Background: The aim of the study was to determine a prognostic value of the neutrophil to lymphocyte ratio (NLR), the platelet to lymphocyte ratio (PLR) and the lymphocyte to monocyte ratio (LMR) ratios for survival of patients, operated on due to non-small cell lung cancer (NSCLC). Methods: The study was conducted on 532 patients, operated on due to NSCLC, in stages IA-IIIA. A total of 174 females and 358 males, aged 36-84 years (the mean age: 63.6 years) were included in the study. The following factors were subject to a statistical analysis, conducted for determination of potential prognostic values of NLR, PLR and LMR ratios: age, sex, nicotinism, the number of leukocytes, neutrophils, monocytes, platelets, histopathological diagnosis, T category, N category, the Charlson comorbidity index (CCI), kind of surgery, patient survival. Results: The single-factor analysis revealed a relationship between NLR, PLR and LMR values, CCI values, the number of monocytes and the length of survival. The multi-factor analysis confirmed that for patients with expected 2-year survival, PLR above 138 (P=0.0008) is another negative prognostic factor, apart from the stage of the neoplastic disease and CCI above 4. For 5-year survival, such a relationship was not observed. Conclusions: The PLR ratio is an independent and significant prognostic factor for expected, over 2-year survival of patients operated on due to NSCLC.

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Section: Discussionmentioning

confidence: 93%

Prognostic value of neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratio ratios in patients operated on due to non-small cell lung cancer

et al. 2019

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“…[10] It has significant contribution to the prognostic assessment of NSCLC. The prognostic value of many inflammation-based scores such as modified Glasgow Prognostic Score, [11] neutrophil-lymphocyte ratio, [12] and platelet-to-lymphocyte ratio [13] have been validated in NSCLCs. In addition, previous studies have indicated that the levels of serum C-reactive protein (CRP) and albumin correlate with the survival outcome of patients with NSCLCs.…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of C-reactive protein/albumin ratio on the overall survival of patients with advanced nonsmall cell lung cancers receiving palliative chemotherapy

Koh¹,

Lee

2017

Medicine

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Recent studies have indicated that the C-reactive protein (CRP)/albumin (CRP/Alb) ratio is associated with clinical outcomes in patients with various carcinomas. However, no studies have explored the association between the ratio of CRP/Alb and clinical outcome of inoperable patients with nonsmall cell lung cancers (NSCLCs). We examined the prognostic impact of CRP/Alb ratio on 165 stage IV NSCLC receiving palliative chemotherapy. The optimal cutoff level of CRP/Alb ratio was set at 0.195. The median follow-up time was 9 months (range, 1–74 months). On univariate analysis, high CRP/Alb ratio (≥0.195) was correlated (P < .001) with poorer overall survival (OS). Subgroup analysis of adenocarcinoma showed that CRP/Alb ratio was significantly (P < .001) associated with OS. Multivariate analysis showed that CRP/Alb ratio was an independent prognostic factor for OS (hazard ratio: 2.227, P = .001). Subgroup analysis revealed that the CRP/Alb ratio had a significant (P = .001) prognostic impact on adenocarcinoma patients receiving platinum chemotherapy. Elevated CRP/Alb ratio was significantly associated with male gender (P = .002) and smoking history (P = .009). The results of this study suggest that the CRP/Alb ratio might be used as a simple, inexpensive, and independent prognostic factor for OS of patients with advanced lung adenocarcinomas receiving platinum chemotherapy.

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“…Operative injury causes acute phase responses in the body and this response has been examined by several biomarkers such as cortisol, interleukin-6, white cell count, and CRP (15) . Other biomarkers of systemic inflammation such as neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio have also been reported to be effective predictors of outcomes in various surgical procedures (16)(17)(18) . The CAR is a novel systemic inflammation biomarker and a high ratio of CAR indicates higher residual inflammation superimposed with malnutrition status (13) .…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Preoperative High-Sensitivity C-Reactive Protein/Albumin Ratio in Spinal Surgery

Acarbaş¹

2019

TERH

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Objective: The relation high-sensitivity C-reactive protein/albumin ratio (CAR) with perioperative adverse events have not been studied in patients undergoing spinal surgery (SS). This study aimed to evaluate the prognostic value of preoperative CAR on outcome of patients undergoing elective SS. Method: A retrospective analysis of 811 consecutive patients, older than 18 years old and undergoing elective SS between October 2014 and January 2019 was performed. Demographic and clinical data were obtained from medical records. Routine preoperative laboratory tests including high-sensitivity C-reactive protein and albumin levels were recorded. The outcomes of interest were perioperative medical and surgical complications during hospitalization. Results: The perioperative adverse event rate was 9.0% (73 patients). The CAR was higher in in the individuals that experienced complicated in-hospital course than in those who did not (30.2±27.5 vs. 15.8±24.5, p<0.001). Multivariate analysis showed that only age, higher CAR, and history of malignancy were significant and independent predictors of perioperative adverse events. The best cutoff value of the CAR was 5.25, with 84.3% sensitivity and 85.2% specificity. Conclusion: This is the first study to show an association between preoperative CAR and perioperative adverse events in patients undergoing SS.

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Platelet-to-Lymphocyte Ratio and Use of NSAIDs during the Perioperative Period as Prognostic Indicators in Patients with NSCLC Undergoing Surgery

Cited by 27 publications

References 34 publications

Prognostic value of neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratio ratios in patients operated on due to non-small cell lung cancer

Prognostic value of neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratio ratios in patients operated on due to non-small cell lung cancer

Prognostic impact of C-reactive protein/albumin ratio on the overall survival of patients with advanced nonsmall cell lung cancers receiving palliative chemotherapy

Prognostic Value of Preoperative High-Sensitivity C-Reactive Protein/Albumin Ratio in Spinal Surgery

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