Platelet-To-Lymphocyte Ratio is a Marker of Poor Prognosis in Patients With Diabetes Mellitus and ST-Elevation Myocardial Infarction

Abstract

PLR proved to have good prognostic value for in-hospital and late mortality. PLR cut-off value for predicting in-hospital mortality was higher to that predicting late mortality. PLR remained an independent risk factor early and late mortality.

Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction

“…We identified PLR to have a moderate-togood prognostic value for in-hospital (AUC 0.61 (95% CI 0.56-0.65) P = 0.006) and late mortality (AUC 0.77 95% CI 0.73-0.80 P b 0.0001). In multivariate analysis, PLR remained an independent factor of long-term mortality (HR 1.08 95% CI: 1.03-1.12 P b 0.0001) (Hudzik et al, 2015).…”

“…Thus far, many authors reported a high admission PLR to be a significant predictor short-and long-term mortality in patients with acute coronary syndromes (Cho, Ann, Singh, Her, & Shin, 2015;Cicek et al, 2015;Hudzik et al, 2015;Ozcan Cetin et al, 2016;Toprak et al, 2015). Ozcan Cetin et al examined PLR prognostic value on in-hospital and long-term MACE (stent thrombosis, nonfatal myocardial infarction, and mortality) in patients with STEMI.…”

“…Detailed information on venous blood collection and handling has been described in detail previously (Hudzik et al, 2015). Diabetes mellitus was defined as: (a) pre-existing condition diagnosed before STEMI (patients on insulin, oral glucose-lowering drugs or on a diet), (b) newly diagnosed diabetes mellitus based on fasting plasma glucose (FPG) ≥ 7.0 mmol/L or 2-h plasma glucose ≥11.1 mmol/L during an oral glucose tolerance test (OGTT) (Ryden et al, 2007).…”

“…Numerous studies have shown that of IL-6 and C-reactive protein (CRP) concentrations correlate with infarct size, reperfusion, short-term and long-term prognosis (Frangogiannis, Smith, & Entman, 2002;Ziakas et al, 2006). Recently, platelet-to-lymphocyte ratio (PLR) has emerged as a new and strong marker of worse outcomes in acute coronary syndromes (Azab, Shah, Akerman, & McGinn, 2012;Hudzik et al, 2015;Kurtul et al, 2014). However, it was first introduced as an inflammatory marker that predicted poor outcomes in cancer patients (Smith et al, 2009).…”

Platelet to Lymphocyte Ratio as a Prognostic Marker of In-Hospital and Long-Term Major Adverse Cardiovascular Events in ST-Segment Elevation Myocardial Infarction

“…9,10 Current studies have reported that higher PLR values were associated with the no-reflow phenomenon, increased SYNTAX score, impaired infarct artery patency, and worsening in-hospital and short-term outcomes in STEMI. 8,[11][12][13][14][15][16] There is no comprehensive study investigating the importance of this parameter on long-term major adverse cardiovascular events (MACE) in this population. Therefore, we assessed the prognostic value of PLR on inhospital and long-term MACE in patients with STEMI undergoing primary percutaneous coronary intervention (pPCI) in a large prospective study.…”