Platelet volume subpopulations in acute myocardial infarction: an investigation of their homogeneity for smoking, infarct size and site

Yt, Kishk; Ea, Trowbridge; Jf, Martín

doi:10.1042/cs0680419

Cited by 61 publications

(40 citation statements)

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“…In humans, the increased platelet reactivity has been associated with platelet size changes 1 which have been confirmed in recent studies. 3 " 5 This evidence suggests that there may be alterations in platelet production in vascular disease. Two further observations support this hypothesis.…”

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confidence: 96%

Platelet and megakaryocyte changes in cholesterol-induced experimental atherosclerosis.

Martin¹,

Slater²,

Kishk³

et al. 1985

Arteriosclerosis

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Rabbits were fed either 2 g cholesterol in 10 ml olive oil daily with normal diet (n = 5) or normal diet alone (n = 5). After 12 weeks, the cholesterol-fed animals had developed fatty plaques involving 24% ± 4% of the surface area of the aorta; the control animals had none. Mean platelet volume was significantly smaller (p < 0.04) in the cholesterol-fed animals (4.1 ± 0.3 fl) compared with the controls (4.8 ± 0.4 fl). The heterogeneity of the average volume distributions of the two groups, characterized by the statistical parameters of the coefficient of variation, skewness, and kurtosis, was also significantly different. Platelet count was significantly higher (p < 0.001) in the cholesterol-fed group (7.48 ± 1.06 x 10" platelets/liter blood) compared to the control group (4.86 ± 0.60 x 10 11 platelets/liter blood). Mean megakaryocyte cytoplasmic volume was significantly larger (p < 0.001) in the cholesterol-fed rabbits (12,262 ± 1485 fl) compared with controls (6,814 ± 761 fl). The range of cytoplasmic volumes was also significantly increased in the cholesterol-fed rabbits. A significant (p < 0.01) increase in mean megakaryocyte nuclear volume in the cholesterol-fed animals was accompanied by a nonsignificant increase in mean nuclear DNA content: 30.2 ± 3.7 N compared with a control value of 23.6 ± 4.0 N. This evidence indicates that a high cholesterol diet in rabbits is associated with changes in platelet production from megakaryocytes as well with as the development of atherosclerosis. (Arteriosclerosis 5:604-612, November/December 1985) P latelets in vascular disease have increased reactivity in both human and animal models. 12 The cause of this increased reactivity may either be an effect of vessel wall changes on normal platelets or be related to an intrinsic change in the platelets themselves. In humans, the increased platelet reactivity has been associated with platelet size changes 1 which have been confirmed in recent studies.3 " 5 This evidence suggests that there may be alterations in platelet production in vascular disease. Two further observations support this hypothesis. Men who suffered sudden cardiac death associated with atheromatous arteries had larger megakaryocytes than a control group who died unexpectedly from unnatural causes.6 Similar large megakaryocytes, which produced larger than normal platelets, were also observed in men with acute myocardial infarction.

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mentioning

confidence: 96%

Platelet and megakaryocyte changes in cholesterol-induced experimental atherosclerosis.

Martin¹,

Slater²,

Kishk³

et al. 1985

Arteriosclerosis

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“…So, increased risk of acute coronary syndromes in young patients with high MPV may be explained with the increased activity of platelets, increased inflammation and increased platelet aggregation (19 Many studies of MPV in ACS have been published. In one of them, MPV was found to be elevated in patients with STEMI (20). In another, Pereg et al (21) found an association between unsuccessful thrombolytic therapy and an increased MPV in patients with STEMI.…”

Section: Discussionmentioning

confidence: 95%

Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study

Özlü¹,

Öztürk²,

Ayhan³

et al. 2012

Anadolu Kardiyol Derg

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Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study ST-yükselmesiz ABSTRACTObjective: Platelets play an important role in both initiation and propagation of acute coronary syndromes. We sought to evaluate the predictive value of mean platelet volume (MPV) in young patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS).Methods: This is a retrospective observational study; evaluating the MPV values of 79 NSTE-ACS patients aged under 45 years and 45 control subjects having normal coronary anatomy. NSTE-ACS group was composed of 41 non-ST elevation myocardial infarction (NSTEMI) and 38 unstable angina pectoris (USAP) patients. MPV was measured using an automated hematologic analyzer called Coulter counter. The predictive value of MPV was evaluated using logistic regression analysis and comparison of MPV between NSTE-ACS and control groups was performed by Mann-Whitney U test. Results: The MPV was found to be significantly higher in the NSTE-ACS compared with control group (8.49±1.22 versus 7.78±0.65 fL, p=0.001).In logistic regression analysis, MPV was found to be an independent predictor of NSTE-ACS (OR=3.1, 95% CI 1.

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“…For example; there is a correlation between the mean platelet volume (MPV) and the functional status of platelets. In many studies, it was showed that MPV was higher in the patients with CAD and acute coronary syndrome in proportion to the normal individuals (Kishk et al, 1985;Bath et al, 1996). Moreover, MPV was detected to be an independent indicator of reperfusion and mortality (Huczek et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Platelet to Lymphocyte Ratio with Presence and Severity of Metabolic Syndrome

Kaya

Bektaş²,

Kaya³

et al. 2015

Mid. Black Sea J of Health Sci.

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Objective: The aim of this study is to evaluate the relation between the components of Metabolic syndrome (MS) and the inflammation and the platelet-to-lymphocyte ratio (PLR) recognized as a novel marker of pro-thrombotic state. Method: 70 patients with MS criteria were included in the study. 70 healthy people with matching age and gender characteristics were included in the study as the control group. The patients were divided into three groups with regard to the number of MS characteristics: Group 1 (the patients with three MS criteria), group 2 (the patients with four MS criteria), and group 3 (the patients with five MS criteria). PLR was calculated in regard to the complete blood count. Results: The patients with MS had significantly higher PLR level compared to those without MS. However, PLR level were not associated with severity of MS. A moderate positive correlation was revealed between the severity of MS and PLR (r=0.419, p<0.001) and a strong positive correlation between the severity of MS and hs-CRP (r=0.562, p<0.001). Also, a positive correlation was detected between hs-CRP and PLR in our patient population (r=0.281, p=0.002). In order to specify the level of PLR to predict MS, ROC curve analysis was performed. The cut-off level for PLR with optimal sensitivity and specificity was calculated as 0,132 (Area under curve [AUC] =0. 744 [0.655-0.833], p<0.001). For that level, the sensitivity was 73% and the specificity was 68, 4%. Conclusion: This is the first study which determines the fact that there is a relation between MS criteria, the inflammation and PLR, which is a new marker of the pro-thrombotic state. There is also a positive correlation between PLR and hs-CRP in these patients. PLR may be beneficial in predicting the adverse cardiovascular cases in the patients with MS.

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Platelet volume subpopulations in acute myocardial infarction: an investigation of their homogeneity for smoking, infarct size and site

Cited by 61 publications

References 0 publications

Platelet and megakaryocyte changes in cholesterol-induced experimental atherosclerosis.

Platelet and megakaryocyte changes in cholesterol-induced experimental atherosclerosis.

Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study

Correlation of Platelet to Lymphocyte Ratio with Presence and Severity of Metabolic Syndrome

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