Plateletpheresis concentrates produced with the COMTEC cell separator: the French experience

Coffe, C; Benguella, Moktar; Domy, M.; Cottier, Dominique; Guignier, Freddy; N'gondara, Jean Philippe; Carrère, Anne; Masse, M; Naegelen, Christian; Biggio, Bernard; Tiberghien, Pierre; Hervé, P.; Bouzgarrou, R; Maurel, Jean Paul; Vezon, G; Vidal, Madeleine; Quainon, Fabienne; Benamara, Abdelhalim; Lamy, B.; Beaumont, Jean Louis; Bierling, Philippe; Gondrexon, Geneviève; Schooneman, F.; Janot, C.; Villard, François; Huart, J. J.

doi:10.1016/s1473-0502(01)00089-1

Cited by 10 publications

(16 citation statements)

References 11 publications

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“…In the present study, we noted a CE of 55 ± 15% with the Amicus and of 57 ± 15% with the COM.TEC (p = 0.477). Compared to results reported in the literature, our COM.TEC CE results (57 ± 15%) were similar to those reported: 52-55% [13,17,18]. However, our Amicus results (55 ± 15%) were lower than the reported averages of 66-73% [8][9][10][11][19][20][21][22].…”

Section: Discussionsupporting

confidence: 85%

“…Although a variety of apheresis devices are currently available on the market for plateletpheresis procedures, there are scant data concerning plateletpheresis with the COM.TEC machine [13,17,18]. Additionally, there is no published data comparing the COM.TEC and the Amicus instruments used for platelet- pheresis.…”

Section: Discussionmentioning

confidence: 99%

“…'doing more in less time', is as key a feature as yield when evaluating equipment. Coffe et al [17] recorded the French experience on plateletpheresis with the COM.TEC cell separator; the blood volume processed was 4,606-5,229 l, and the mean separation time was between 87-109 min to reach a target PLT yield of 4.74 × 10 11 to 5.95 × 10 11 with the COM.TEC machine. Moog et al [18] reported an average processed blood volume of 2,826 ± 409 ml in a donation time of 55 ± 11 min; the mean PLT yield of these products was 3.11 ± 0.40 × 10 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Leukocytes must be <5 × 10 6 per concentrate according to USA standards and <1 × 10 6 per concentrate according to European standards [14,15]. Coffe et al [17] reported that the residual leukocyte levels were <1 × 10 6 per concentrate (mean 0.233 ± 0.150 × 10 6 ) in more than 97% of the components produced (confidence interval (CI) of >95%). Moog et al [18] recorded mean WBC contaminations of 0.11 ± 0.20 × 10 6 with the COM.TEC.…”

Section: Discussionmentioning

confidence: 99%

“…Efficient platelet collection with fewer procedure-related side effects is an important consideration for donors. The most common procedural adverse effects are citrate related [16][17][18]24]; the incidence of citrate toxicity varies from 0.11 to 16% in different studies [8,[25][26][27][28]. Citrate-related reactions have been observed in 0.5% of cases on the COM.TEC machine [17].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Plateletpheresis on the Fenwal Amicus and Fresenius Com.Tec Cell Separators

Altuntaş

Sarı²,

Koçyiğit³

et al. 2008

Transfus Med Hemother

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Background: A variety of apheresis devices are now available on the market for plateletapheresis. We compared two apheresis instruments (Fenwal Amicus and Fresenius COM.TEC) with regard to processing time, platelet (PLT) yield and efficiency, and white blood cell (WBC) content. Material and Methods: Donors undergoing plateletpheresis were randomly separated into two groups (either the Amicus or the COM.TEC cell separator). Results: In the pre-apheresis setting, 32 plateletpheresis procedures performed with each instrument revealed no significant differences in donors’ sex, age, weight, height and total blood volume between the two groups. However, the preapheresis PLT count was higher with the COM.TEC than with the Amicus (198 ×10³/µl vs. 223 ×10³/µl; p = 0.035). The blood volume processed to reach a target PLT yield of ≧3.3 ×10¹¹ was higher in the COM.TEC compared to the Amicus (3,481 vs. 2,850 ml; p < 0.001). The median separation time was also significantly longer in the COM.TEC than in the Amicus (61 vs. 44 min; p < 0.001). 91 and 88% of the PLT products collected with the Amicus and the COM.TEC, respectively, had a PLT count of ≧3.3 ×10¹¹ (p = 0.325). All products obtained with both instruments had WBC counts lower than 5 ↔10⁶, as required. There was no statistical difference with regard to collection efficiency between the devices (55 ± 15 vs. 57 ± 15%; p = 0.477). However, the collection rate was significantly higher with the Amicus compared to the COM.TEC instrument (0.077 ± 0.012 ×10¹¹ vs. 0.057 ± 0.008 ×10¹¹ PLT/min; p < 0.001). Conclusion: Both instruments collected platelets efficiently. Additionally, consistent leukoreduction was obtained with both instruments; however, compared with the COM.TEC instrument, the Amicus reached the PLT target yield more quickly.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Comparison of Plateletpheresis on the Fenwal Amicus and Fresenius Com.Tec Cell Separators

Altuntaş

Sarı²,

Koçyiğit³

et al. 2008

Transfus Med Hemother

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Comparison of plateletpheresis on the Fenwal Amicus, Fresenius COM.TEC, and Trima Accel Cell separators

Nacak

Eser

Kaynar

et al. 2014

J of Clinical Apheresis

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Blood component donations by apheresis have become more common in modern blood transfusion practices. We compared three apheresis instruments (Fenwal Amicus, Fresenius COM.TEC, and Trima Accel) with regard to platelet (PLT) yield, collection efficiency (CE), and collection rate (CR). The single-needle or double-needle plateletpheresis procedures of the three instruments were compared in a retrospective, randomized study in 270 donors. The blood volume processed was higher in the COM.TEC compared with the Amicus and Trima. Also there was a significantly higher median volume of ACD used in collections on the COM.TEC compared with the Amicus and Trima. The PLT yield was significantly lower with the COM.TEC compared with the Amicus and Trima. Additionally, the CE was significantly lower with the COM.TEC compared with the Amicus and Trima. There was no significant difference in median separation time and CR between the three groups. When procedures were compared regarding CE by using Amicus device, it was significantly higher in single-needle than double-needle plateletpheresis. When double-needle Amicus system was compared with double-needle COM.TEC system, CE and PLT yield were significantly higher with Amicus system. When single-needle Amicus system was compared with single-needle Trima system, CE and PLT yield were significantly higher with Trima system. All instruments collected PLTs efficiently. However, the CE was lower with the COM.TEC compared with the Amicus and Trima. Also, we found Amicus single-needle system collected PLTs more efficiently compared with the double-needle system. CE and PLT yields were significantly higher with the single-needle Trima instrument compared with the single-needle Amicus device.

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A prospective quality evaluation of single donor platelets (SDP) – An experience of a tertiary healthcare center in India

Pandey¹,

Tiwari²,

Sharma³

et al. 2012

Transfusion and Apheresis Science

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Plateletpheresis concentrates produced with the COMTEC cell separator: the French experience

Cited by 10 publications

References 11 publications

Comparison of Plateletpheresis on the Fenwal Amicus and Fresenius Com.Tec Cell Separators

Comparison of Plateletpheresis on the Fenwal Amicus and Fresenius Com.Tec Cell Separators

Comparison of plateletpheresis on the Fenwal Amicus, Fresenius COM.TEC, and Trima Accel Cell separators

A prospective quality evaluation of single donor platelets (SDP) – An experience of a tertiary healthcare center in India

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