2015
DOI: 10.1111/trf.13350
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Platelets made HLA deficient by acid treatment aggregate normally and escape destruction by complement and phagocytes in the presence of HLA antibodies

Abstract: Our study fills an important knowledge gap in how acid treatment affects PLT function and interactions with immune cells, paving the way for controlled clinical trials to evaluate acid-treated PLTs as an alternative to HLA-matched donors in PLT refractoriness.

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Cited by 31 publications
(66 citation statements)
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“…Increased collaborations between transfusion centers, sharing information on HLA‐typed platelet donors and helping each other by sharing donated units, particularly in smaller countries, would most likely improve matching. Further research in new HLA Class I–deficient platelet products will also be important to pursue …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Increased collaborations between transfusion centers, sharing information on HLA‐typed platelet donors and helping each other by sharing donated units, particularly in smaller countries, would most likely improve matching. Further research in new HLA Class I–deficient platelet products will also be important to pursue …”
Section: Discussionmentioning
confidence: 99%
“…Further research in new HLA Class I-deficient platelet products will also be important to pursue. 26,27 Table S1. Transfusion data.…”
Section: Discussionmentioning
confidence: 99%
“…The characteristics of HLA‐eliminated platelets prepared by this method are summarised in Table . The recovery of the platelet count was 91%, an extremely high level compared with the conventional centrifugation method (73%) . The average collected volume increased 1·4 times after the preparation.…”
Section: Resultsmentioning
confidence: 85%
“…However, presently, the techniques used to obtain pure platelets from human HSC and iPS are still not completely established, and the cost to obtain a sufficient number of platelets for transfusion is extremely expensive. As to the latter, although some reports have shown the efficacy of acid-treated platelets even in clinical situations [10][11][12][13], the recovery after acid treatment was relatively low (approximately 70%) [10,14].…”
Section: Introductionmentioning
confidence: 99%
“…Transfusion of high platelet doses increases the transfusion interval and can reduced the number of Platelet concentrates required by thrombocytopenic patients that signifi cantly reducing donor exposure [29,11]. HLA an HPA-matched platelets [30,31]; or as an alternative HLA class I eluted platelets should be used for succesful treatment of platelet transfusion refractoriness [32]. Washed platelet concentrates in patients with febrile non-haemolytic transfusion reactions should be used [33].…”
Section: Discussionmentioning
confidence: 99%