Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries

Rentschler, Gerda; Rodushkin, Ilia; Černá, Milena; Chen, Chunying; Harari, Florencia; Harari, Raúl; Horvat, Milena; Hrubá, F; Kašparová, Lucie; Koppová, Kvetoslava; Krsková, Andrea; Krsnik, Mladen; Laamech, Jawhar; Li, Yu Feng; Löfmark, Lina; Lundh, Thomas; Lundström, Nils Göran; Lyoussi, Badiâa; Mazej, Darja; Osredkar, Joško; Pawlas, Krystyna; Pawlas, Natalia; Prokopowicz, Adam; Skerfving, Staffan; Tratnik, Janja Snoj; Spěváĉková, Věra; Špirić, Zdravko; Sundkvist, Anneli; Strömberg, Ulf; Vadla, Draženka; Wranova, Katerina; Zizi, Soumia; Bergdahl, Ingvar A.

doi:10.1016/j.ijheh.2017.10.017

Cited by 21 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…V České republice byla v rámci MZSO získána řada výsledků, které umožnily účast SZÚ v mnoha mezinárodních projektech např. PHIME, ESBIO a COPHES-DEMOCOPHES, jejichž výsledky byly publikovány v mezinárodních prestižních časopisech (7)(8)(9).…”

Section: úVodunclassified

Human biomonitoring in the Czech Republic. Overview of the results obtained in the framework of the Population Health Monitoring System since 1994

Černá¹,

Krsková²,

Grafnetterová³

et al. 2023

Hygiena

View full text Add to dashboard Cite

Přehledový článek shrnuje výsledky českého lidského biomonitoringu za téměř tři dekády své existence. Národní biologický monitoring byl ve Státním zdravotním ústavu v Praze uveden do činnosti v roce 1994 v rámci Systému monitorování zdravotního stavu obyvatelstva České republiky ve vztahu k životnímu prostředí, aby byl posléze navázán na evropské a světové odborné aktivity v této oblasti. V jeho průběhu byla sledována celá škála organických i anorganických xenobiotik a esenciálních látek v krvi, moči a vlasech dospělé a dětské populace, v mateřském mléce kojících žen a také v dalších, méně obvyklých matricích. Výstupem jsou cenné dlouhodobé časové řady, které mj. ukazují, jakým způsobem mohou fungovat zavedená preventivní opatření v praxi a jak korespondují se snižující se expozicí populace. Na druhé straně lze jeho prostřednictvím ověřit, zda a jak rychle může dojít k expozici člověka nově používaným chemickým látkám. Správně interpretované výsledky lidského biologického monitoringu jsou důležité pro odborníky z oblasti veřejného zdraví ke stanovení referenčních hodnot, k porovnání se zdravotními limity, k hodnocení zdravotních rizik, pro účely zdravotní politiky i k mezinárodnímu srovnání. Ve vhodně zpracované podobě mohou sloužit k informovanosti a vzdělávání laické veřejnosti o zátěži lidské populace chemickými látkami z prostředí. Dlouhodobé zkušenosti z oblasti českého biologického monitoringu umožňují Státnímu zdravotnímu ústavu účast v mnoha zahraničních projektech, zaměřených na sledování expozice různých populačních skupin chemickým látkám z prostředí.

show abstract

Section: úVodunclassified

Human biomonitoring in the Czech Republic. Overview of the results obtained in the framework of the Population Health Monitoring System since 1994

Černá¹,

Krsková²,

Grafnetterová³

et al. 2023

Hygiena

View full text Add to dashboard Cite

show abstract

“…However, the increased use of PGEs as components of autocatalytic converters attached to motor vehicles has resulted in the urban environment being seriously polluted by Pt. Several studies have suggested that PGEs and their complexes in airborne particulate matter (PM) may be one of the causes of health disorders such as asthma, allergies, and rhinoconjunctivitis [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Health Risk Assessment of Exposure to 15 Essential and Toxic Elements in Spanish Women of Reproductive Age: A Case Study

Saéz

Sánchez

Yusà

et al. 2021

IJERPH

View full text Add to dashboard Cite

This case study investigates the exposure of 119 Spanish women of reproductive age to 5 essential (Co, Cu, Mn, V, Zn) and 10 toxic (Ba, Be, Cs, Ni, Pb, Pt, Sb, Th, Al, U) elements and assesses their risk. The essential elements (Co, Cu, Mn, V, and Zn) showed average concentrations (GM: geometric mean) of 0.8, 35, 0.5, 0.2, and 347 μg/L, respectively. Five of the toxic elements (Ba, Cs, Ni, Al, U) exhibited detection frequencies of 100%. The GM concentrations of the novel toxic elements were 12 μg/L (Al), 0.01 μg/L (Pt), 0.02 μg/L (U), 0.12 μg/L (Th), 0.009 μg/L (Be) and 4 μg/L (Cs). The urine analysis was combined with a survey to assess any variations between subgroups and potential predictors of exposure to elements in the female population. Significant differences were obtained between the rural and urban areas studied for the toxic element Cs, with higher levels found in mothers living in urban areas. In relation to diet, statistically significantly higher levels of essential (Cu) and toxic (Ba) elements were detected in women with a high consumption of fish, while mothers who consumed a large quantity of legumes presented higher levels of the toxic element Ni (p = 0.0134). In a risk-assessment context, hazard quotients (HQs) greater than 1 were only observed for the essential elements Zn and Cu in P95. No deficiency was found regarding the only essential element for which a biomonitoring equivalent for nutritional deficit is available (Zn). For the less-studied toxic elements (Al, Pt, U, Th, Be, and Cs), HQs were lower than 1, and thus, the health risk due to exposure to these elements is expected to be low for the female population under study.

show abstract

“…For instance, platinum levels persist many years after anticancer treatment in the blood of urban women. 26…”

Section: Introductionmentioning

confidence: 99%

“…The long-term storage of Cd by MT in the kidneys raises the question about whether these xenobiotic metals will follow this pathway and bioaccumulate. For instance, platinum levels persist many years after anticancer treatment in the blood of urban women …”

Section: Introductionmentioning

confidence: 99%

“…For instance, platinum levels persist many years after anticancer treatment in the blood of urban women. 26 While the forms of these metal pollutants are generally metallic and considered stable, it is important to remember that these metals are not normally found on the surface of the earth and that their introduction into the ecosystem through mining (runoff), processing, and subsequent consumer product disposal will ultimately cause physiological changes in affected life forms. Without previous knowledge or history with this type of pollutant, it is important to understand the possible response of biological metalloproteins, such as MTs, with metals that humans and the natural world have not traditionally but are now becoming increasingly exposed to.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Metallothionein: An Aggressive Scavenger—The Metabolism of Rhodium(II) Tetraacetate (Rh₂(CH₃CO₂)₄)

Wong

Stillman

2018

ACS Omega

View full text Add to dashboard Cite

Anthropogenic sources of xenobiotic metals with no physiological benefit are increasingly prevalent in the environment. The platinum group metals (Pd, Pt, Rh, Ru, Os, and Ir) are found in marine and plant species near urban sources, and are known to bioaccumulate, introducing these metals into the human food chain. Many of these metals are also being used in innovative cancer therapy, which leads to a direct source of exposure for humans. This paper aims to further our understanding of nontraditional metal metabolism via metallothionein, a protein involved in physiologically important metal homeostasis. The aggressive reaction of metallothionein and dirhodium(II) tetraacetate, a common synthetic catalyst known for its cytotoxicity, was studied in detail in vitro. Optical spectroscopic and equilibrium and time-dependent mass spectral data were used to define binding constants for this robust reaction, and molecular dynamics calculations were conducted to explain the observed results.

show abstract

Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries

Cited by 21 publications

References 31 publications

Human biomonitoring in the Czech Republic. Overview of the results obtained in the framework of the Population Health Monitoring System since 1994

Human biomonitoring in the Czech Republic. Overview of the results obtained in the framework of the Population Health Monitoring System since 1994

Health Risk Assessment of Exposure to 15 Essential and Toxic Elements in Spanish Women of Reproductive Age: A Case Study

Metallothionein: An Aggressive Scavenger—The Metabolism of Rhodium(II) Tetraacetate (Rh₂(CH₃CO₂)₄)

Contact Info

Product

Resources

About

Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries

Cited by 21 publications

References 31 publications

Human biomonitoring in the Czech Republic. Overview of the results obtained in the framework of the Population Health Monitoring System since 1994

Human biomonitoring in the Czech Republic. Overview of the results obtained in the framework of the Population Health Monitoring System since 1994

Health Risk Assessment of Exposure to 15 Essential and Toxic Elements in Spanish Women of Reproductive Age: A Case Study

Metallothionein: An Aggressive Scavenger—The Metabolism of Rhodium(II) Tetraacetate (Rh2(CH3CO2)4)

Contact Info

Product

Resources

About

Metallothionein: An Aggressive Scavenger—The Metabolism of Rhodium(II) Tetraacetate (Rh₂(CH₃CO₂)₄)