Platinum Porphyrin -Au-NPs Hybrid Material for Optical Detection of Hydrocortisone

Abstract

The purpose of this work was to determine whether novel hybrid nanomaterials obtained in mild synthesis conditions between a Pt (II) metalloporphyrin, namely: Pt (II) 5,10,15,20-tetra (4-methoxy-phenyl)-porphyrin (PtTMeOPP) and nanoGold (n-Au) offer better recognition or detection properties toward hydrocortisone than the solely uncombined compounds. The Pt-porphyrin, gold-colloid and the hybrid nanomaterials were synthesized and characterized by UV-vis, FT-IR, 1H-NMR, AFM and TEM microscopy. For the concentrations of hydrocortisone that have relevance for medical field, covering the range of 10-8 to 10-7 M, an excellent correlation of 0.99 was obtained between the intensity of absorption of the n-Au-PtTMeOPP hybrid plasmon and the hydrocortisone concentration, measured in THF-water system. So, this n-Au-PtTMeOPP conjugate system can be further developed to implement an accurate hydrocortisone optical sensor.