Platinum(<scp>ii</scp>) and palladium(<scp>ii</scp>) complexes with methyl 3,4-diamino-2,3,4,6-tetradeoxy-α-<scp>l</scp>-lyxo-hexopyranoside

Samochocka, K.; Fokt, Izabela; Anulewicz‐Ostrowska, Romana; Przewloka, Teresa; Mazurek, Andrzej; Fuks, L.; Lewandowski, W.; Kozerski, Lech; Bocian, Wojciech; Bednarek, Elżbieta; Lewandowska, Hanna; Sitkowski, Jerzy; Priebe, Waldemar

doi:10.1039/b212681h

Cited by 17 publications

(19 citation statements)

References 23 publications

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“…In a similar attempt to develop DNA-targeted cytotoxic agents series of platinum (II) and paladium (II) complexes with methyl 3,4-diamino-2,3,4,6-tetradeoxy-α-L-lyxohexapyranoside have been synthesized and characterized [76]. This synthetic ligand mimics the structure of daunosamine, the aminosugar residue abundant in daunorubicin and doxorubicin.…”

Section: +mentioning

confidence: 98%

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Novel Approaches Towards Development of Non-Classical Platinum-Based Antineoplastic Agents: Design of Platinum Complexes Characterized by an Alternative DNA-Binding Pattern and/or Tumor-Targeted Cytotoxicity

Momekov¹,

Bakalova²,

Karaivanova

2005

CMC

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Cisplatin is an essential antineoplastic agent whose introduction in clinical use revolutionized the treatment of several solid malignancies, especially those of germinative origin. The unfavorable toxicological profile of this drug, however as well as the resistance of some common malignancies solicited the search of platinum complexes, characterized by lower toxicity and/or broader antitumor spectrum. Thus during the last three decades a plethora of several thousand platinum coordination compounds have been synthesized and evaluated as potential antineoplastic agents. Despite of the numerous compounds investigated however only few of the proved to be of clinical significance and actually none of them could be considered as an ideal substitute for cisplatin regarding both lower toxicity and broader spectrum of anticancer activity. To a great extent the platinum-based drug discovery was confined at structural modification of the parent compound in line with the classic structure-activity relationship concept. Conversely, since the majority of platinum complexes developed so far are closely related structural analogues of cisplatin, it is not surprising that they produce similar cellular effects and any altered pattern of antitumor activity and/or toxicity is likely to be due to pharmacokinetic, rather than truly mechanistic, factors. Studies over the last few years have shown that the structural resemblance to cisplatin is not an absolute requirement for cytotoxicity, which broadens the search for cisplatin analogues towards non-classical compounds with prominent structural/pharmacodynamic dissimilarity to the prototype. This review covers the major approaches to elaboration of non-classical platinum complexes with emphasis on complexes interacting with DNA in a cisplatin-dissimilar fashion and complexes with tumor-targeted cytotoxicity.

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Section: +mentioning

confidence: 98%

“…This synthetic ligand mimics the structure of daunosamine, the aminosugar residue abundant in daunorubicin and doxorubicin. Daunosamine, in contrast to the minor-groove intercalating properties of the anthracyclin aglycons, is known to interact with the negatively charged phosphate moieties in the major groove [3,76].…”

Section: +mentioning

confidence: 99%

Novel Approaches Towards Development of Non-Classical Platinum-Based Antineoplastic Agents: Design of Platinum Complexes Characterized by an Alternative DNA-Binding Pattern and/or Tumor-Targeted Cytotoxicity

Momekov¹,

Bakalova²,

Karaivanova

2005

CMC

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“…The investigations of molecular mechanisms concerning the influence of metals on the electronic systems of biologically important ligands now we apply in search of novel antimicrobial [40,70] and antitumour molecules [71][72][73]. This research is very important due to continuously increasing compound resistance of the tumour and bacterial cells and by high toxicity of currently applied compounds [74].…”

Section: Introductionmentioning

confidence: 99%

The influence of metals on the electronic system of biologically important ligands. Spectroscopic study of benzoates, salicylates, nicotinates and isoorotates. Review

Lewandowski

Kalinowska

Lewandowska

2005

Journal of Inorganic Biochemistry

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159

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“…Priebe has examined cisplatin complexes with polyaminosaccharide ligands containing a modified doxorubicin carbohydrate molecule Samochocka et al 2003). The saccharides create complexes of great stability and easily modifiable lipophilicity.…”

Section: Davidson Et Al 2002; Espinosa Et Al 2003mentioning

confidence: 99%

A review of selected anti-tumour therapeutic agents and reasons for multidrug resistance occurrence

Sawicka

Kalinowska

Skierski

et al. 2004

Journal of Pharmacy and Pharmacology

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It is assumed that proteins from the ABC family (i.e., glycoprotein P (Pgp)) and a multidrug resistance associated protein (MRP) play a main role in the occurrence of multidrug resistance (MDR) in tumour cells. Other factors that influence the rise of MDR are mechanisms connected with change in the effectiveness of the glutathione cycle and with decrease in expression of topoisomerases I and II. The aim of this review is to characterize drugs applied in anti-tumour therapy and to describe the present state of knowledge concerning the mechanisms of MDR occurrence, as well as the pharmacological agents applied in reducing this phenomenon.

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Platinum(ii) and palladium(ii) complexes with methyl 3,4-diamino-2,3,4,6-tetradeoxy-α-l-lyxo-hexopyranoside

Cited by 17 publications

References 23 publications

Novel Approaches Towards Development of Non-Classical Platinum-Based Antineoplastic Agents: Design of Platinum Complexes Characterized by an Alternative DNA-Binding Pattern and/or Tumor-Targeted Cytotoxicity

Novel Approaches Towards Development of Non-Classical Platinum-Based Antineoplastic Agents: Design of Platinum Complexes Characterized by an Alternative DNA-Binding Pattern and/or Tumor-Targeted Cytotoxicity

The influence of metals on the electronic system of biologically important ligands. Spectroscopic study of benzoates, salicylates, nicotinates and isoorotates. Review

A review of selected anti-tumour therapeutic agents and reasons for multidrug resistance occurrence

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