Platycodon grandiflorum-derived saponin attenuates the eccentric exercise-induced muscle damage

Kim, Yong-An; Oh, Suck-Hoon; Lee, Gi-Ho; Hoa, Pham Thi; Jin, Sun Woo; Chung, Young Chul; Lee, Young Chun; Jeong, Hye Gwang

doi:10.1016/j.fct.2017.12.045

Cited by 13 publications

(5 citation statements)

References 46 publications

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“…Researchers have shown much interest in investigating Platycodon grandiflorum . Saponin obtained from Platycodon grandiflorum is effective in reducing scrotal spermatogenic damage and suppressing oxidative stress and apoptosis in mice (Leng et al., 2019); decreasing muscle damage from exercise (Kim et al, 2018); and supporting muscle protein synthesis and mitochondrial function (Kim et al, 2018). Extracts of Platycodon grandiflorum seeds and roots showed insulin resistance in skeletal muscle cell model (Yoon, Bang, Kim, & Imm, 2018).…”

Section: Introductionmentioning

confidence: 99%

Platycodon grandiflorumroots: A comprehensive study on odor/aroma and chemical properties during roasting

et al. 2020

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Platycodon is a ubiquitous plant widely grown in Asia. This study investigated changes in odor/aroma associated sensory attributes and chemical properties in Platycodon grandiflorum roots upon roasting. Amino acid analysis, electronic tongue analysis, chemical property analysis, volatile compound analysis, GC‐olfactometry‐assisted sensory attributes, and electronic nose analysis were performed. In results, amino acid profiles showed diverse patterns. Electronic tongue analysis somewhat corresponded to the free amino acid profiles. Total phenolic content, antioxidant capacity, and browning intensity significantly increased up to 4 min and slightly decreased afterward. Various pyrazines relevant to roasted odor such as 3‐ethyl‐2, 5‐dimethyl‐pyrazine, and 2, 6‐dimethyl‐pyrazine were generated by roasting. In electronic nose analysis, positive odor parameter significantly increased and potential unpleasant odorants significantly decreased over time. This is believed to be the first study demonstrating overall insight on odor/aroma and chemical characteristics and utilizing objective sensory measures on roasted Platycodon grandiflorum roots for food applications. Practical applications This study will be utilized (a) to researchers and food companies who are interested in medicinal foods (b) to individuals and food industry that search for changes in sensory characteristics and chemical changes of foods induced by roasting, and (c) to farmers and crop producers who look for utilization and applications of Platycodon grandiflorum roots as food sources and ingredients.

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Section: Introductionmentioning

confidence: 99%

Platycodon grandiflorumroots: A comprehensive study on odor/aroma and chemical properties during roasting

et al. 2020

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“…The importance of diet and food is supported by the top ten co-cited references (three studies using milk or Montmorency cherry) and co-citation clusters [ 33 , 34 , 36 , 89 ]. Diet and food containing various ingredients (clusters #9 nitrate-rich beetroot juice and #20 grandiflorum-derived saponin) have also been studied to alleviate EIMD [ 66 , 92 ]. Overall, diet and food are a more practical and secure alternative to supplements for athletes to prevent unintentional doping [ 93 ].…”

Section: Discussionmentioning

confidence: 99%

Exercise-Induced Muscle Damage and Protein Intake: A Bibliometric and Visual Analysis

Zeng

Liu

et al. 2022

Nutrients

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Numerous studies have covered exercise-induced muscle damage (EIMD) topics, ranging from nutritional strategies to recovery methods, but few attempts have adequately explored and analyzed large volumes of scientific output. The purpose of this study was to assess the scientific output and research activity regarding EIMD and protein intake by conducting a bibliometric and visual analysis. Relevant publications from 1975–2022 were retrieved from the Web of Science Core Collection database. Quantitative and qualitative variables were collected, including the number of publications and citations, H-indexes, journals of citation reports, co-authorship, co-citation, and the co-occurrence of keywords. There were 351 total publications, with the number of annual publications steadily increasing. The United States has the highest total number of publications (26.21% of total publications, centrality 0.44). Institutional cooperation is mostly geographically limited, with few transnational cooperation links. EIMD and protein intake research is concentrated in high-quality journals in the disciplines of Sport Science, Physiology, Nutrition, and Biochemistry & Molecular Biology. The top ten journals in the number of publications are mostly high-quality printed journals, and the top ten journals in centrality have an average impact factor of 13.845. The findings of the co-citation clusters and major keyword co-occurrence reveal that the most discussed research topics are “exercise mode”, “nutritional strategies”, “beneficial outcomes”, and “proposed mechanisms”. Finally, we identified the following research frontiers and research directions: developing a comprehensive understanding of new exercise or training models, nutritional strategies, and recovery techniques to alleviate EIMD symptoms and accelerate recovery; applying the concept of hormesis in EIMD to induce muscle hypertrophy; and investigating the underlying mechanisms of muscle fiber and membrane damage.

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“…Several oxidative stress-related markers were examined, and the results showed increased antioxidant capacity in the formula group, evidenced by a lower MDA level, as well as higher GSH levels and CAT activity in the muscles ( Figure 5 ). In support of oxidative stress amelioration, the key muscle damage marker, CK, and the LDH level [ 34 , 35 ] were reduced in response to the formula treatment ( Figure 6 ). However, no significant effect was evident on the antioxidant protein expression after formula supplementation.…”

Section: Discussionmentioning

confidence: 99%

A Multi-Ingredient Formula Ameliorates Exercise-Induced Fatigue by Changing Metabolic Pathways and Increasing Antioxidant Capacity in Mice

Chen

Cao

et al. 2021

Foods

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Multiple mechanisms are involved in exercise-induced fatigue, including energy depletion, metabolite accumulation, and oxidative stress, etc. The mechanistic findings provide a rationale for a multi-targeted approach to exercise-induced fatigue management. This study created a multi-ingredient formula mixed with valine, isoleucine, leucine, β-alanine, creatine, l-carnitine, quercetin, and betaine, based on the functional characteristics of these agents, and evaluated the preventive effect of this mechanism-based formula on exercise-induced fatigue. Results showed that the 7-d formula supplement significantly increased the running duration time of mice by 14% and the distance by 20% in an exhaustive treadmill test, indicating that the formula could delay fatigue appearance and improve exercise performance. Mechanistically, the formula enhanced fatty acid oxidation and spared liver glycogen by regulating the fat/glucose metabolism-related signaling pathways, including phospho-adenosine monophosphate-activated protein kinase α (p-AMPKα), phospho-acetyl CoA carboxylase (p-ACC), carnitine palmitoyl-transferase 1B (CPT1B), fatty acid translocase (CD36), and glucose transporter type 4 (GLUT4), and increased antioxidant capacity. The findings suggested that the formula tested in this study effectively ameliorated exercise-induced fatigue by targeting multi-signaling pathways, showing promise as a regimen to fight exercise-induced fatigue.

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Platycodon grandiflorum-derived saponin attenuates the eccentric exercise-induced muscle damage

Cited by 13 publications

References 46 publications

Platycodon grandiflorumroots: A comprehensive study on odor/aroma and chemical properties during roasting

Platycodon grandiflorumroots: A comprehensive study on odor/aroma and chemical properties during roasting

Exercise-Induced Muscle Damage and Protein Intake: A Bibliometric and Visual Analysis

A Multi-Ingredient Formula Ameliorates Exercise-Induced Fatigue by Changing Metabolic Pathways and Increasing Antioxidant Capacity in Mice

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