Pleofungins, Novel Inositol Phosphorylceramide Synthase Inhibitors, from Phoma sp. SANK 13899

Aoyagi, Azusa; Yano, Taka-aki; Kozuma, Shiho; Takatsu, Toshio

doi:10.1038/ja.2007.14

Cited by 16 publications

(7 citation statements)

References 25 publications

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“…It is a rare case where a CDP contains three subsequent lactone bonds. These CDPs showed inhibitory activity on inositol phosphorylcermide synthase [ 209 , 210 ].…”

Section: Cyclic Nonadepsipeptidesmentioning

confidence: 99%

Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi

et al. 2018

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Cyclic depsipeptides (CDPs) are cyclopeptides in which amide groups are replaced by corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the peptide structure. These peptides sometimes display additional chemical modifications, including unusual amino acid residues in their structures. This review highlights the occurrence, structures and biological activities of the fungal CDPs reported until October 2017. About 352 fungal CDPs belonging to the groups of cyclic tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-, and tridecadepsipeptides have been isolated from fungi. These metabolites are mainly reported from the genera Acremonium, Alternaria, Aspergillus, Beauveria, Fusarium, Isaria, Metarhizium, Penicillium, and Rosellina. They are known to exhibit various biological activities such as cytotoxic, phytotoxic, antimicrobial, antiviral, anthelmintic, insecticidal, antimalarial, antitumoral and enzyme-inhibitory activities. Some CDPs (i.e., PF1022A, enniatins and destruxins) have been applied as pharmaceuticals and agrochemicals.

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“…It is a rare case where a CDP contains three subsequent lactone bonds. These CDPs showed inhibitory activity on inositol phosphorylcermide synthase [ 209 , 210 ].…”

Section: Cyclic Nonadepsipeptidesmentioning

confidence: 99%

Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi

et al. 2018

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“…The same was found for khafrefungin, 68,69 an IPC inhibitor with a similar structure. In this respect the haplofungins differ from the cyclic depsipeptide pleofungin A 70,71 an IPC inhibitor which exhibits also very strong antifungal activities.…”

Section: Introductionmentioning

confidence: 99%

Fungal natural products in research and development

2014

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To date approximately 100 000 fungal species are known although far more than one million are expected. The variety of species and the diversity of their habitats, some of them less exploited, allow the conclusion that fungi continue to be a rich source of new metabolites. Besides the conventional fungal isolates, an increasing interest in endophytic and in marine-derived fungi has been noticed. In addition new screening strategies based on innovative chemical, biological, and genetic approaches have led to novel fungal metabolites in recent years. The present review focuses on new fungal natural products published from 2009 to 2013 highlighting the originality of the structures and their biological potential. Furthermore synthetic products based on fungal metabolites as well as new developments in the uses or the biological activity of known compounds or new derivatives are discussed.

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“…One of the inhibitors of this metabolic enzyme is pleofungins (also called F-15078) produced by the endophytes Phoma sp. SANK 13899 and is active against Saccharomyces cerevisiae, Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans (Aoyagi et al 2007). Phomafungin a cyclic lipodepsipeptide exhibits a broad spectrum of antifungal activity in very low concentration against Candida sp., Aspergillus fumigatus, and Trichophyton mentagrophytes (Herath et al 2009).…”

Section: Antimicrobial Activitymentioning

confidence: 99%