Pleural Tuberculosis and its Treatment Outcomes

Khan, Amer Hayat; Sulaiman, Siti Noraini; Muttalif, AR; Akram, Hamzah; Gillani, Syed Wasif

doi:10.4314/tjpr.v12i4.27

Cited by 3 publications

(5 citation statements)

References 18 publications

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“…Plevral tüberküloz eksuda özelliğindeki plevral sıvıların en yaygın nedenlerinden biridir ve TB prevalansının yüksek olduğu ülkelerde mikobakteri antijenlerine karşı gelişen gecikmiş tip aşırı duyarlılık reaksiyonuna bağlı olarak oluşur. TB prevalansının düşük olduğu ülkelerde ise, plevra tüberkülozunun çoğunlukla TB reaktivasyonunun bir komplikasyonu sonucunda oluştuğu kabul edilmektedir (14) . Türkiye gibi TB prevalansının yüksek olduğu ülkelerde TP daha çok primer enfeksiyonun komplikasyonu sonucu ortaya çıktığı için genç erişkin ve adölesanlarda daha sık rastlanmaktadır (15) .…”

Section: Discussionunclassified

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Retrospective Evaluation of 38 Patients with Tuberculous Pleurisy in Mersin

Ülger¹,

Kurnaz²,

Ülger³

et al. 2019

TMCD

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Objective: Tuberculous pleurisy (TP) is the second most common form of extrapulmonary tuberculosis after tuberculous lymphadenitis and in developing countries it is one of the major causes of exudative pleural effusion. In this study, we aimed to retrospectively evaluate the mycobacteriological and histopathological results and demographic data of patients with suspect TP. Method: Between January 2006 and February 2018; clinical, microbiological and histopathological features of 38 patients with TP were retrospectively evaluated. In addition to the culture method, considered to be the gold standard in the diagnosis of TP, cases with positive acid-fast bacilli (AFB) in their clinical specimens and/or cases that were diagnosed histopathologically as TP were included in this study. Results: Of the 38 TP cases, 31 (81.6%) were culture positive (pleural fluid 39.5%; pleural tissue 42.1%), and chronic granulomatosis inflammation was detected in 30 (79%) cases (pleural fluid 31.6%; pleural tissue 47.4%) with histopathological examination. While 5 (13.1%) of the cases were positive only with culture and 3 (7.9%) were positive only with histopathological examination, 23 (60.5%) cases were found to be positive by both methods. Of these cases, 22 (57.9%) were male, 16 (42.1%) were female and the mean age was 43 (2-82) years. The most common symptoms among the cases were respiratory disorder, cough and chest pain. Conclusion: In cases with pleural effusion, combined use of microbiological and histopathological diagnostic methods is thought to increase the diagnostic rate significantly.

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Section: Discussionunclassified

“…Khan ve ark. 'nın (14) yaptığı çalışmada, olgularda en sık görülen klinik semptomların öksürük (%91.2) ateş (%86.2), göğüs ağrısı (%63.8) ve gece terlemesi (%65) olduğu rapor edilmiştir. Ekinci ve ark.…”

Section: Discussionunclassified

Retrospective Evaluation of 38 Patients with Tuberculous Pleurisy in Mersin

Ülger¹,

Kurnaz²,

Ülger³

et al. 2019

TMCD

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“…Hal ini tidak sesuai dengan banyak penelitian lain yang dilakukan di daerah endemik TB (Valdes dkk pada tahun 1998 dan 2010 serta Khan dkk tahun 2013) yang menyatakan bahwa jumlah penderita efusi pleura TB pada laki-laki adalah lebih banyak dari perempuan. [13][14][15] Hal ini mungkin dikarenakan bahwa RSUD Dr. Soetomo adalah rumah sakit rujukan utama di Wilayah Indonesia Timur sehingga penderita yang dirawat kebanyakan adalah penderita yang sudah tidak bisa ditangani oleh fasilitas kesehatan lain, sedangkan diagnosis efusi pleura TB biasanya masih bisa ditangani oleh fasilitas kesehatan lain tersebut sehingga penderita jarang dirujuk ke RSUD Dr. Soetomo. Hal ini menyebabkan angka insiden serta karakteristik penderita efusi pleura TB di RSUD Dr. Soetomo tidak bisa mencerminkan gambaran sebenarnya yang ada di Surabaya dan Jawa Timur.…”

Section: Pendahuluanunclassified

Nilai Diagnostik Adenosine Deaminase (ADA) Cairan Pleura pada Penderita Efusi Pleura Tuberkulosi

Amalia

Pradjoko

2019

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Background: Tuberculosis pleural effusion is the most common extrapulmonary TB after lymphadenitis TB. Limited diagnostic methods make TB pleural effusion hard to diagnose. Adenosine deaminase ADA is an enzyme in purin catabolism process which catalyze adenosine into inosine and deoksiadenosine into deoksiinosin. This process is important in lymphoid cell differentiation. ADA is elevated in TB pleural effusion. Method: This study was a cross sectional analytic observational. Statistic analysis was using two independent samples T test. ROC curve was used to determine cut off value of ADA. Kappa test was used to determined the level of agreement of ADA cut off value. Results: Forty eight samples were included in this study, 18 samples with TB pleural effusion and 30 samples with non TB pleural effusion. There was significant difference between pleural fluid ADA in TB and non TB. Positivity of AFB sputum and MTB culture did not show any significant differences. Cut off ADA value for TB pleural effusion diagnosis was 39,19 with sensitivity 88,9% and spesificity 90%. Conclusion: Examination of ADA level in pleural fluid is a usefull tool to diagnose TB pleural effusion.

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“…This emphasizes the need to diagnose and manage tuberculous pleural effusion effectively. A study in Malaysia has concluded that a good overall treatment outcome of pleural tuberculosis is determined by early detection of the disease and implementing measures to ensure high adherence rate [28]. Thus, the major challenge in managing pleural tuberculosis remains in effective diagnosis.…”

Section: Tuberculous Pleural Effusionmentioning

confidence: 99%

“…A cost analysis study in India has established that pleural fluid interferon gamma levels are more sensitive compared to pleural ADA levels in diagnosing tuberculosis pleural effusion [35]. However, the same study has concluded that, the cost of performing this additional test in diagnosis one tuberculous pleuritis patient is equivalent to the cost of anti-tuberculosis treatment of six patients [28]. Thus, in developing countries where resources of medical treatment are limited, these tests may not be cost effective [35].…”

Section: Tuberculous Pleural Effusionmentioning

confidence: 99%

Unusual Presentations of Tuberculosis: A Case Series

Dayalan¹,

Johnson²,

Kasinathan³

et al. 2016

OALib

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Introduction: Tuberculosis (TB) is an airborne infection caused by the organism Mycobacterium Tuberculosis that can affect any organ though it commonly involves infection of the lungs. Given the nature of Extra-Pulmonary Tuberculosis (EPTB) that has various form of clinical manifestation, diagnosing EPTB remains a challenge. Background: This report discusses three cases of EPTB that posed diagnostic and management challenges. The first case presented as pleural effusion and TB was diagnosed on pleural biopsy. The second case presented with abdominal pain and mass in the right iliac fossa. Final diagnosis of tuberculous colitis was made post-laparotomy and he underwent successful anti-tuberculous treatment. The third case presented with a single enlarged cervical lymph node and a typical history. Investigations were suggestive of tuberculous lymphadenitis and patient showed a positive response to anti-tuberculous treatment. Conclusion: EPTB has various forms of clinical manifestation, which imposes diagnostic and treatment challenges. Thus, it is crucial to always include tuberculosis as part of working diagnosis especially in regions where tuberculosis is endemic until proven otherwise. Hence it is imperative to start treatment early to ensure better response.

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Pleural Tuberculosis and its Treatment Outcomes

Abstract: (Odds ratio, 95 % CI, p = 0.025

Cited by 3 publications

References 18 publications

Retrospective Evaluation of 38 Patients with Tuberculous Pleurisy in Mersin

Retrospective Evaluation of 38 Patients with Tuberculous Pleurisy in Mersin

Nilai Diagnostik Adenosine Deaminase (ADA) Cairan Pleura pada Penderita Efusi Pleura Tuberkulosi

Unusual Presentations of Tuberculosis: A Case Series

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