Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain

Jayakumar, Thanasekaran; Muniyan, Sakthivel; Thomas, Philip A.; Geraldine, Pitchairaj

doi:10.1016/j.cbi.2008.08.006

Cited by 94 publications

(73 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Here, CCl 4 -treated rats exhibited a significant increase in testicular MDA, as have been reported previously (8,15). The higher membrane lipid content of Leydig cell mitochondria and microsomes may explain the susceptibility of the testis to lipid peroxidation in CCl 4 exposed rats.…”

Section: Sperm Parameterssupporting

confidence: 88%

“…In the present work, the histopathological results revealed marked alteration and degeneration of germ cells after CCl 4 treatment which may be a reason for the decreased testicular weights observed in the present and earlier reports (4,15,20). The action of CCl 4 on the testes may be ascribed as a direct toxic action of CCl 4 on the tissues and is likely to impair gonadal response to FSH and LH; and diminish the production of testosterone.…”

Section: Sperm Parameterssupporting

confidence: 80%

See 1 more Smart Citation

Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

et al. 2016

View full text Add to dashboard Cite

The increased generation of free radicals plays an important role in testicular damage. The present study aimed to investigate the adverse effects of carbon tetrachloride (CCl 4 ) on the reproductive system of male rats as well as to examine whether Vitamin E (VE) is able to ameliorate these effects. The rats were equally divided into three groups: control, CCl 4 -treated, and CCl 4 + VE-treated groups. After 4 weeks of treatment, the decrease in body and testes weights, sperm parameters, and the decrease in serum levels of testosterone, luteinizing hormone, and folliclestimulating hormone of CCl 4 -treated rats were ameliorated by VE treatment. The co-administration of VE with CCl 4 significantly decreased the level of lipid peroxidation production (malondialdehyde) and increased the activity of anti-oxidant enzymes (superoxide dismutase and catalase) when compared with the CCl 4 group. Moreover, VE prevented CCl 4 -induced severe testicular histopathological lesions and deformities in spermatogenesis. The results demonstrate that VE augments the anti-oxidants' defense mechanism against CCl 4 -induced reproductive toxicity suggesting a therapeutic role in free radical-mediated infertility.

show abstract

Section: Sperm Parameterssupporting

confidence: 88%

Section: Sperm Parameterssupporting

confidence: 80%

Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Several studies are available in the literature investigating decreased antioxidant enzymes in liver, kidneys, heart and brain (Ramesh et al, 2012) in aged rats. Our previous studies have documented that the activities of SOD, CAT, Gpx, GR and GST are reduced in major organs of aged (Jayakumar et al, 2007) and carbon tetrachloride (CCl 4 )-induced (Jayakumar et al, 2006(Jayakumar et al, , 2008 rats. We also found a decreased glutathione redox system (GSH and GR) in aged rats (Jayakumar et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…The antioxidant activity of the exopolysaccharides (EPS) and intracellular polysaccharides (IPS) obtained from the mycelia of two edible P. ostreatus strains, PQMZ91109 and PSI101109, in a batch bioreactor was demonstrated by Vamanu et al (2013). Our previous studies have demonstrated that treatment of an extract of P. ostreatus enhances the activities of CAT, SOD, Gpx, GR and GST in the liver, kidney heart and brain of aged (Jayakumar et al, 2007) and CCl 4 -induced rats (Jayakumar et al, 2006(Jayakumar et al, , 2008. The present study investigates whether treatment with P. ostreatus can ameliorate oxidative damage in liver, kidneys, heart and brain of aged rats via improving of G6PDH, Apx and decreasing of XDH activities.…”

Section: Introductionmentioning

confidence: 99%

Pleurotus ostreatus, an edible mushroom, enhances glucose 6-phosphate dehydrogenase, ascorbate peroxidase and reduces xanthine dehydrogenase in major organs of aged rats

Thomas

Geraldine

Jayakumar

2014

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Aging is now considered to be associated with an elevation in oxidative damage to macromolecules and enhanced levels of inflammation. Therefore, inhibition of age-related oxidative stress by natural supplement is an important study. Objectives: To investigate whether the treatment with Pleurotus ostreatus (Jacq.: Fr) Kumm, (Pleurotaceae) can ameliorate oxidative damage in aged rats. Materials and methods: Male Wistar rats were divided into three groups of six each: group 1, normal young rats; group 2, normal aged untreated rats; group 3, normal aged rats treated with P. ostreatus (200 mg/kg body wt administered intraperitoneally for 21 days). On the 22nd day, rats were sacrificed by decapitation; the liver, kidneys, heart and brain were removed from each rat for the biochemical and isozyme analyses of the antioxidant enzymes glucose 6-phosphate dehydrogenase (G6PDH), ascorbate peroxidase (Apx) and xanthine dehydrogenase (XDH). Results: An elevated activity of XDH was observed in the liver (G2:13.72 AE 4.1 versus G1: 7.57 AE 1.15; p50.05), kidneys (G2:101.48 AE 12.3 versus G1: 31.15 AE 1.71; p50.01), heart (G2: 63.21 AE 3.96 versus G1: 37.3 AE 2.70; p50.01) and brain (G2: 39.02 AE 3.96 versus G1: 19.84 AE 1.22; p50.001). The activities of G6PDH and Apx were lowered in major organs of aged untreated rats. However, treatment of P. ostreatus to aged rats resulted in decreased XDH and increased G6PDH and Apx activities in liver, kidneys, heart and brain. Interestingly, analyses of isozyme pattern of these enzymes are support the results obtained from the spectrophotometric determinations. Conclusion: These results suggest that an extract of P. ostreatus can protect the age-related oxidative damage in major organs of Wistar rats by enhancing the antioxidant enzymes G6PDH and Apx and by reducing XDH.

show abstract

“…Besides its organoleptic quality, P. eryngii is acknowledged as a good dietary source of bioactive compounds with reported effects on the reduction of hyperlipidemia (Chen et al, 2012), tumor growth, hepatogenic and atherosclerotic conditions Yang et al, 2013). Most of the available reports describe the polysaccharide fraction of P. eryngii, which was highlighted as having antioxidant, anti-aging, anti-tumor and hepatoprotective activity (Gan, Ma, Jiang, Wang, & Zeng, 2012;Jayakumar, Sakthivel, Thomas, & Geraldine, 2008). Nevertheless, other important bioactive compounds such as polyphenols, peptides, sterols and dietary fiber were also reported in this species (Chen et al, 2012;Ferreira, Barros, & Abreu, 2009;Mishra et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties

et al. 2017

View full text Add to dashboard Cite

a b s t r a c tMushrooms are important sources of natural bioactive compounds. Pleurotus eryngii (DC.) Quél is recognized for its organoleptic quality and health effects, being extensively commercialized. Instead, Suillus bellinii (Inzenga) Watling is an ectomycorrhizal symbiont, whose main properties were scarcely reported. Considering current trends, the mycelia and the culture media of these mushrooms might be potential sources of bioactive compounds. Accordingly, P. eryngii and S. bellinii were studied for their phenolic acids and sterols, antioxidant capacity, anti-inflammatory effect and anti-proliferative activity. S. bellinii mycelia showed higher contents of ergosterol and phenolic compounds (also higher in its fruiting body) and stronger antioxidant activity than P. eryngii. Conversely, P. eryngii mycelia showed anti-inflammatory (absent in S. bellinii mycelia) and a cytotoxicity similar (sometimes superior) to its fruiting bodies, contrarily to S. bellinii. Furthermore, the assayed species showed differences in the growth rate and produced mycelia, which should be considered in further applications.

show abstract

Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain

Cited by 94 publications

References 52 publications

Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

Pleurotus ostreatus, an edible mushroom, enhances glucose 6-phosphate dehydrogenase, ascorbate peroxidase and reduces xanthine dehydrogenase in major organs of aged rats

Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties

Contact Info

Product

Resources

About