2015
DOI: 10.2147/ijn.s79489
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PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

Abstract: The clinical success of the applicability of tea polyphenols awaits efficient systemic delivery and bioavailability. Herein, following the concept of nanochemoprevention, which uses nanotechnology for enhancing the efficacy of chemotherapeutic drugs, we employed tea polyphenols, namely theaflavin (TF) and epigallocatechin-3-gallate (EGCG) encapsulated in a biodegradable nanoparticulate formulation based on poly(lactide-co-glycolide) (PLGA) with approximately 26% and 18% encapsulation efficiency, respectively. … Show more

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Cited by 60 publications
(39 citation statements)
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“…The literature reports opposite effects, either demonstrating higher resistance of differentiated THP-1 cells [42,43] or establishing lower susceptibility for A549 cells [44], clearly indicating that the generated responses are strongly dependent on the assessed materials. What is clearly seen in our study is that there was a difference of susceptibilities when testing free drugs and polymer, which are exposed as solutions, comparing with microparticles.…”
Section: Evaluation Of Metabolic Activitymentioning
confidence: 99%
“…The literature reports opposite effects, either demonstrating higher resistance of differentiated THP-1 cells [42,43] or establishing lower susceptibility for A549 cells [44], clearly indicating that the generated responses are strongly dependent on the assessed materials. What is clearly seen in our study is that there was a difference of susceptibilities when testing free drugs and polymer, which are exposed as solutions, comparing with microparticles.…”
Section: Evaluation Of Metabolic Activitymentioning
confidence: 99%
“…45,46 The drug-loading content (DL) was defined as the weight (W) ratio of the loaded drug to the drug-loaded SLNs. The drug encapsulation efficiency (EE) was calculated from the weight (W) ratio between the drug incorporated in SLNs and that fed in the fabrication:…”
Section: Determination Of Drug Loading and Entrapment Efficiencymentioning
confidence: 99%
“…Furthermore, the in vitro (Singh et al, 2011), and in vivo (Singh et al, 2015) synergism recorded when EGCG was delivered in association with CP, offers new therapeutic opportunities for some invasive human cancer diseases.…”
Section: Polymeric Nanoparticlesmentioning
confidence: 99%