PLGA Spherical Nucleic Acids

Zhu, Shengshuang; Xing, Hang; Gordiichuk, Pavlo; Park, Jung Soo; Mirkin, Chad A.

doi:10.1002/adma.201707113

Cited by 93 publications

(78 citation statements)

References 39 publications

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“…Introduction of chemical modifications may enhance the stability and biological performance of the DNA nanostructures. In 2018, Zhu et al prepared SNAs that contain DNA oligonucleotides with a PS backbone and showcased their immunotherapeutic potential by activating Toll‐like receptors in macrophages . Future investigations should focus on how such modifications influence the geometry, thermodynamic stability, binding affinity to receptors, and other parameters.…”

Section: Discussionmentioning

confidence: 99%

Progress toward Understanding the Interactions between DNA Nanostructures and the Cell

Chiu

Choi

2019

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Advances in DNA nanotechnology empower the programmable assembly of DNA building blocks (oligonucleotides and plasmids) into DNA nanostructures with precise architectural control. As DNA nanostructures are biocompatible and can naturally enter mammalian cells without the aid of transfection agents, they have found numerous biological or biomedical applications as delivery carriers of therapeutic and imaging cargoes into mammalian cells for at least a decade. Nevertheless, mechanistic studies on how DNA nanostructures interact with cells have remained limited and incomprehensive until 2–3 years ago. This Review presents the recent progress in elucidating the “cell–nano” interactions of DNA nanostructures, with an emphasis on three key classes of structures commonly utilized in intracellular applications: tile‐based structures, origami‐based structures, and nanoparticle‐templated structures. Structural parameters of DNA nanostructures and strategies of biochemical modification for promoting intracellular delivery are discussed. Biological mechanisms for cellular uptake, including specific pathways and receptors involved, are outlined. Routes of intracellular trafficking and degradation, together with strategies for re‐directing their trafficking, are delineated. This Review concludes with several aspects of the “bio–nano” interactions of DNA nanostructures that warrant future investigations.

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Section: Discussionmentioning

confidence: 99%

Progress toward Understanding the Interactions between DNA Nanostructures and the Cell

Chiu

Choi

2019

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“…26 It is used extensively to prepare microparticles and nanoparticles to deliver a wide range of therapeutic agents including active pharmacological molecules, 27 peptides, 28 and nucleic acids. 29 Therapeutic nanocarriers had shown promising results in the treatment of cancer partly due to the enhanced selective uptake in cancer tissue through the tumor capillaries a property known as the enhanced permeability and retention (EPR) effect. 30,31 This effect is due to the disruption in the integrity of tumor capillaries and the inflamed endothelial cells potentiating the extravasation of nanocarriers through the leaky vasculature and enhancing the targeting strategy of treatment.…”

Section: Introductionmentioning

confidence: 99%

<p>Formulation, Cellular Uptake and Cytotoxicity of Thymoquinone-Loaded PLGA Nanoparticles in Malignant Melanoma Cancer Cells</p>

Ibrahim

Rosli

Doolaanea

2020

IJN

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Introduction: Thymoquinone (TQ) is the main active compound extracted from Nigella sativa a traditional herb with wide therapeutic applications and recognizable anticancer properties. This study aimed to formulate and characterize TQ-nanoparticles using PLGA as a biocompatible coating material (TQ-PLGA NPs) with the evaluation of its therapeutic properties in human melanoma cancer cells. Methods: The TQ-PLGA NPs were prepared and characterized for size, zeta potential, encapsulation efficiency, and release profile. Results: The particle size was 147.2 nm, with 22.1 positive zeta potential and 96.8% encapsulation efficiency. The NPs released 45.6% of the encapsulated TQ within 3 h followed by characteristic sustained release over 7 days with a total of 69.7% cumulative release. TQ-PLGA NPs were taken up effectively by the cells in a time-dependent manner up to 24 h. Higher cell toxicity was determined within the first 24 h in melanoma cells due to the rapid release of TQ from the NPs and its low stability in the cell culture media. Conclusion: TQ-PLGA NPs is a potential anticancer agent taking advantage of the sustained release and tailored size that allows accumulation in the cancer tissue by the enhanced permeability and retention effect. However, stability problems of the active ingredient were address in this study and requires further investigation.

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“…Attention has been focused on developing biodegradable and non-toxic materials for applications in biomedicine fields, especially as drug carrier. [4][5][6] Most anti-inflammatory drugs have a short half-life and must be taken several times a day to maintain effective levels. [7] Furthermore, the rate of drug delivery and drug action time are often affected by pH and temperature.…”

Section: Introductionmentioning

confidence: 99%

Cellulose Fibrils Extracted from Bamboo Chips as a Reinforcing Material for Prolonged Drug Release

et al. 2020

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Despite significant improvements in the intelligent delivery of drugs, the search for drug carriers with low cost and long‐term sustainable release still faces enormous challenges. In this study this issue was addressed for porous cellulose‐based aerogels by developing a Temperature/pH stimuli‐responsive carrier for drug controlled release. The prepared aerogels exhibited a smart 3D network with large specific surface area (112.6 m2 g−1) that facilitated the loading and transport of drug molecules. The aerogels were highly responsive to both temperature and pH in aqueous solution, which acted as a good switch for the molecular to control the release by adjusting the solution parameters. Moreover, the cell cytotoxicity and acute oral toxicity tests did not cause specific reactions and showed excellent biocompatibility. The simple manufacturing process, reversible drug release performance as well as the excellent biocompatibility make it a promising candidate for drug delivery.

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PLGA Spherical Nucleic Acids

Cited by 93 publications

References 39 publications

Progress toward Understanding the Interactions between DNA Nanostructures and the Cell

Progress toward Understanding the Interactions between DNA Nanostructures and the Cell

<p>Formulation, Cellular Uptake and Cytotoxicity of Thymoquinone-Loaded PLGA Nanoparticles in Malignant Melanoma Cancer Cells</p>

Cellulose Fibrils Extracted from Bamboo Chips as a Reinforcing Material for Prolonged Drug Release

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