Pluripotent stem cells progressing to the clinic

Trounson, Alan; DeWitt, Natalie

doi:10.1038/nrm.2016.10

Cited by 353 publications

(230 citation statements)

References 73 publications

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“…After laboratory research, extensive pre-clinical evaluation is required to assess the efficacy and safety of the product on invitro disease model before instigating it into human clinical trials. The implementation of therapies on humans as part of clinical trials is a multi-stage process that ultimately confirms the effectiveness of therapies [21].…”

Section: Resultsmentioning

confidence: 98%

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Stem Cells in Regenerative Medicine: Prospects and Pitfalls

Zehravi¹,

Shahid²,

Kashmala³

et al. 2017

Natl. j. health sci.

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Stem cells are the cells that have the ability to regenerate themselves and are able to differentiate into one or more specialized cell types. This unique property makes them a valuable source for in vitro disease modeling, drug designing, regenerative medicine and tissue engineering. As no specie can fully mimic the human microenvironment, human cell models derived from patients cells provide a fascinating avenue for enhancing our current understanding of the early molecular stages of various diseases followed by validating therapeutics. In this paper, we reviewed the role of stem cells in regenerative medicine that includes use of cord blood derived stem cells in medicine and patient specific induced pluripotent stem cells for future transplant purposes and the hurdles and obstacles that we need to address before we can safely use these cells for patient cure.

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Section: Resultsmentioning

confidence: 98%

“…The applications of different cell therapies in clinical trials depend upon multiple factors like scalability, risks and safety profiles [21]. Limbal stem cells, neural stem cells, mesenchymal stem cells and pluripotent stem cells have promising role in regenerative medicine [10].…”

Section: Induced Pluripotent Stem Cells In Regenerative Medicinementioning

confidence: 99%

Stem Cells in Regenerative Medicine: Prospects and Pitfalls

Zehravi¹,

Shahid²,

Kashmala³

et al. 2017

Natl. j. health sci.

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show abstract

“…Overall, the application of stem cell technology in treatment of liver diseases is promising at present (50). Several gene-editing clinical trials have just been approved and will be started in 2017, promoting reprogrammed cell-based therapy (51,52).…”

Section: Transplantation Of Redifferentiated Cells In Liver Therapymentioning

confidence: 99%

Reprogrammed Cell?based Therapy for Liver Disease: From Lab to Clinic

Mehdizadeh

Darabi

2017

jrenhep

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A large number of patients are affected by liver dysfunction worldwide. Liver transplantation is the only efficient treatment in a variety of enduring liver disorders including inherent and end-stage liver diseases. The generation of human functional hepatocytes in high quantities for liver cell therapy is an important goal for ongoing therapies in regenerative medicine. Reprogrammed cells are considered as a promising and unlimited source of hepatocytes, mainly because of their expected lack of immunogenicity and minimized ethical concerns in clinical applications. Despite gained advances in the reprogramming of somatic cells to functional hepatocytes in vitro, production of primary adult hepatocytes that can proliferate in vivo still remains inaccessible. As part of efforts toward translation of cell reprogramming science into clinical practice, more careful cell selection strategies should be integrated into improvement of dedifferentiation and redifferentiation protocols, especially in precision medicine where gene correction is needed. Furthermore, advances in cellular reprogramming highlight the need for developing and evaluating novel standards addressing clinical research interests in this field.

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“…Now, other stem cell types, such as mesenchymal stem cells, are rapidly moving into the clinic and also ES cell and iPS cell-derived cells are being tested in clinical trials [8,9].…”

mentioning

confidence: 99%

Stem cells: from biomedical research towards clinical applications

Zenke

2017

J Mol Med

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Pluripotent stem cells progressing to the clinic

Cited by 353 publications

References 73 publications

Stem Cells in Regenerative Medicine: Prospects and Pitfalls

Stem Cells in Regenerative Medicine: Prospects and Pitfalls

Reprogrammed Cell?based Therapy for Liver Disease: From Lab to Clinic

Stem cells: from biomedical research towards clinical applications

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