Pluronic-F127 and Click chemistry-based injectable biodegradable hydrogels with controlled mechanical properties for cell encapsulation

Sungkhaphan, Piyarat; Risangud, Nuttapol; Hankamolsiri, Weerawan; Sonthithai, Pacharapan; Janvikul, Wanida

doi:10.1016/j.reactfunctpolym.2022.105439

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…Derivatization or modification of copolymer structure was carried out to alleviate some of their shortages [ 90 , 91 ]. These supplementary steps for preparing the gel are time-consuming, and they occasionally introduce a higher level of toxicity into the sample.…”

Section: Discussionmentioning

confidence: 99%

Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems

Lupu¹,

Roșca²,

Gradinaru

et al. 2023

Polymers

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Different formulations containing Pluronic F127 and polysaccharides (chitosan, sodium alginate, gellan gum, and κ-carrageenan) were investigated as potential injectable gels that behave as free-flowing liquid with reduced viscosity at low temperatures and displayed solid-like properties at 37 °C. In addition, ZnO nanoparticles, lysozyme, or curcumin were added for testing the antimicrobial properties of the thermal-sensitive gels. Rheological investigations evidenced small changes in transition temperature and kinetics of gelation at 37 °C in presence of polysaccharides. However, the gel formation is very delayed in the presence of curcumin. The antimicrobial properties of Pluronic F127 gels are very modest even by adding chitosan, lysozyme, or ZnO nanoparticles. A remarkable enhancement of antimicrobial activity was observed in the presence of curcumin. Chitosan addition to Pluronic/curcumin systems improves their viscoelasticity, antimicrobial activity, and stability in time. The balance between viscoelastic and antimicrobial characteristics needs to be considered in the formulation of Pluronic F127 gels suitable for biomedical and pharmaceutical applications.

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Section: Discussionmentioning

confidence: 99%

Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems

Lupu¹,

Roșca²,

Gradinaru

et al. 2023

Polymers

View full text Add to dashboard Cite

show abstract

“…However, owing to its synthetic nature, Pluronic has disadvantages including limited cell adhesion and degradation [ 114 ]. Previous research also shows it dissolves significantly after one week of culture and has questionable cytocompatibility due to potential disruption of the cell membrane [ 114 , 115 ]. Pluronic can be used as a sacrificial bioink for use in making molds, channels, vessels, or vasculature for 3D bioprinting or as a temporary support structure [ 116 ].…”

Section: Biomaterials and Bioinksmentioning

confidence: 99%