Pluronic F127/Doxorubicin microemulsions: Preparation, characterization, and toxicity evaluations

Rahdar, Abbas; Hajinezhad, Mohammad Reza; Barani, Mahmood; Sargazi, Saman; Zaboli, Maryam; Ghazy, Esraa; Baino, Francesco; Cucchiarini, Magali; Bilal, Muhammad; Pandey, Sadanand

doi:10.1016/j.molliq.2021.117028

Cited by 40 publications

(13 citation statements)

References 68 publications

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“…In general, high pH sensitivity is characteristic of the release rate of doxorubicin bound to the carrier through electrostatic interactions [ 62 , 63 ]. The time it takes to reach equilibrium release of electrostatically immobilized doxorubicin by an amphiphilic copolymer of N-vinyl-2-pyrrolidone and acrylic acid is close to that determined in works [ 21 , 22 , 63 ] when gold nanoparticles stabilized with pectin (galacturonic acid) [ 63 ] or microemulsions were used as carriers [ 21 , 22 ]. The application of a pegylated copolymer of lactic and glycolic acids described in [ 37 ] makes it possible to increase the time to reach the equilibrium release of doxorubicin, but it is complicated by a pulsed release of about 20% of the drug at the initial time.…”

Section: Resultssupporting

confidence: 76%

“…Rapidly advancing nanomedicine methods make it possible to reduce the cardiac toxicity of doxorubicin by incorporating it into nanoscale aggregates and providing delivery targeting. Nanoparticles of gold [ 16 ], iron oxide [ 17 ], magnesium aluminum layered double hydroxides [ 18 , 19 ], lipids [ 20 ] and oil-in-water microemulsions [ 21 , 22 ] are promising as carriers for doxorubicin loading. Conjugates with biological molecules, such as human serum albumin (HSA), bovine serum albumin (BSA), milk beta-lactoglobulin (β-LG) [ 23 ], apoferritin [ 24 ] and glycosaminoglycans, as well as platelets [ 25 ], have also been studied as potential doxorubicin carriers.…”

Section: Introductionmentioning

confidence: 99%

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Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

et al. 2022

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Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsulation of hydrophobic drugs, delivery of hydrophilic compounds is typically performed via covalent attachment, which often requires chemical modification of the drug and limits the release kinetics. In this paper, we report synthesis of biphilic copolymers of various compositions capable of self-assembly in water with the formation of nanoparticles and suitable for ionic binding of the common anticancer drug doxorubicin. The copolymers are synthesized by radical copolymerization of N-vinyl-2-pyrrolidone and acrylic acid using n-octadecyl-mercaptan as a chain transfer agent. With an increase of the carboxyl group’s share in the chain, the role of the electrostatic stabilization factor of the nanoparticles increased as well as the ability of doxorubicin as an ion binder. A mathematical description of the kinetics of doxorubicin binding and release is given and thermodynamic functions for the equilibrium ionic binding of doxorubicin are calculated.

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

et al. 2022

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“…This highest antibacterial activity may be due to the intrinsic characteristics of MNPs and starch into MNPs and the synergistic effects observed in the presence of AgNPs. [ 25,74,75 ]…”

Section: Resultsmentioning

confidence: 99%

“…This highest antibacterial activity may be due to the intrinsic characteristics of MNPs and starch into MNPs and the synergistic effects observed in the presence of AgNPs. [25,74,75] It is evident that the overall antibacterial performance is related to the synergistic effect of each component in the nanocomposite having an antibacterial effect. As can be seen from Figure 10A,B, it is clear that, with further increase of Ag concentrations in nanocomposites (MNPs@Starch-Ag/PU-b nanocomposite (8b) and MNPs@Starch-Ag/PU-c nanocomposite (8c)), the inhibition zones not only did not increase but rather decreased; this may be related to AgNP agglomeration in higher concentrations of AgNPs in the nanocomposites which reduced the antibacterial effect.…”

Section: Antibacterial Activitymentioning

confidence: 99%

High antibacterial activity of new eco‐friendly and biocompatible polyurethane nanocomposites based on Fe₃O₄/Ag and starch moieties

Kamali

Faghihi

Mirhoseini

2022

Polymer Engineering & Sci

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Control of microbial infections is one of the growing concerns in modern societies due to the increasing presence and risk of pathogenic bacterial spread. Therefore, there is a strong demand to design new antibacterial agents to overcome these problems. The aim of this study is the preparation of a new series of biocompatible starch‐based polyurethane (PU) nanocomposites with a unique combination of magnetic nanoparticles (MNPs) and silver nanoparticles (AgNPs). In order to perform the study, first, a new synthetic diisocyanate was synthesized by a three‐step reaction and grafted into bis(2‐hydroxyethyl terephthalate) (BHET) and starch as a covering agent of MNPs containing different amounts of AgNPs. Afterward, the diisocyanate containing two active isocyanate moieties was reacted with hydroxyl groups of BHET and starch to form stable urethane linkages. Subsequently, the antibacterial activity of the pure synthetic PU and the produced nanocomposites were investigated against Escherichia coli and Staphylococcus aureus as Gram‐negative and Gram‐positive microorganism models, respectively. The obtained results exhibited that the nanocomposites have a synergistic effect on the antibacterial activity, which decreased with increasing of the Ag content. Such results may be related to the AgNPs agglomeration in the nanocomposite.

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“…This system is thus particularly interesting given the possible applications in many fields. In particular, it is one of the most widely used triblock copolymers in pharmaceutical formulations because of the good water solubility through the high content of EO, the low toxicity in the body and the ability to encapsulate any hydrophobic agents [ 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ]. However, it is well known that the addition of co-solvents or solutes to pluronic water solutions can influence its properties, inducing phase changes [ 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ].…”

Section: Introductionmentioning

confidence: 99%

TiO2 Nanoparticles Dispersion in Block-Copolymer Aqueous Solutions: Nanoarchitectonics for Self-Assembly and Aggregation

Nibali

D’Angelo

Arena

et al. 2022

JFB

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Achieving homogenous dispersion of nanoparticles inside a polymeric matrix is a great challenge for numerous applications. In the present study, we aim at understanding the role of different factors on the dispersion properties of TiO2 in pluronic F-127 mixtures. The mixtures were prepared with different pH and guest/host ratios and investigated by UV-Vis spectroscopy, dynamic light scattering, infrared spectroscopy and electrical conductivity. Depending on the preparation conditions, different amounts of TiO2 were loaded within the copolymer as quantitatively determined by UV-Vis spectroscopy. The different content of nanoparticles has direct implications on the gelation and micellization of pluronic analyzed by dynamic light scattering. The information derived on the self-assembly behavior was interpreted in relation to the infrared and conductivity measurements results. Together, these results shed light on the most favorable conditions for improving the nanoparticle dispersion inside the copolymer matrix and suggest a possible strategy to design functional nanoparticle-polymer systems.

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Pluronic F127/Doxorubicin microemulsions: Preparation, characterization, and toxicity evaluations

Cited by 40 publications

References 68 publications

Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

High antibacterial activity of new eco‐friendly and biocompatible polyurethane nanocomposites based on Fe₃O₄/Ag and starch moieties

TiO2 Nanoparticles Dispersion in Block-Copolymer Aqueous Solutions: Nanoarchitectonics for Self-Assembly and Aggregation

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Pluronic F127/Doxorubicin microemulsions: Preparation, characterization, and toxicity evaluations

Cited by 40 publications

References 68 publications

Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

High antibacterial activity of new eco‐friendly and biocompatible polyurethane nanocomposites based on Fe3O4/Ag and starch moieties

TiO2 Nanoparticles Dispersion in Block-Copolymer Aqueous Solutions: Nanoarchitectonics for Self-Assembly and Aggregation

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High antibacterial activity of new eco‐friendly and biocompatible polyurethane nanocomposites based on Fe₃O₄/Ag and starch moieties