PMIDA-Modified Fe₃O₄ Magnetic Nanoparticles: Synthesis and Application for Liver MRI

Abstract

The surface modification of FeO-based magnetic nanoparticles (MNPs) with N-(phosphonomethyl)iminodiacetic acid (PMIDA) was studied, and the possibility of their use as magnetic resonance imaging contrast agents was shown. The effect of the added PMIDA amount, the reaction temperature and time on the degree of immobilization of this reagent on MNPs, and the hydrodynamic characteristics of their aqueous colloidal solutions have been systematically investigated for the first time. It has been shown that the optimum condition for the modification of MNPs is the reaction at 40 °C with an equimolar amount of PMIDA for 3.5 h. The modified MNPs were characterized by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric, and CHN elemental analyses. The dependence of the hydrodynamic characteristics of the MNP colloidal solutions on the concentration and pH of the medium was studied by the dynamic light scattering method. On the basis of the obtained data, we can assume that the PMIDA molecules are fixed on the surface of the MNPs as a monomolecular layer. The modified MNPs had good colloidal stability and high magnetic properties. The calculated relaxivities r and r were 341 and 102 mmol s, respectively. The possibility of using colloidal solutions of PMIDA-modified MNPs as a T contrast agent for liver studies in vivo (at a dose of 0.6 mg kg) was demonstrated for the first time.

Size Control, Chemical Kinetics, and Theoretical Analysis for the Production of Fe3O4 Nanoparticles with a High Specific Absorption Rate

“…Using these SAR estimations, the average of the dissipated power loss density (P) can be obtained by eq 9, considering the density ρ = 1.040 g/cm 3 . It is noteworthy that the maximum power density reached was 114.17 W/cm 3 , indicating the possibility of dissipating 114 W into 1 cm 3 of tumor tissues.…”

Inspirations of Cobalt Oxide Nanoparticle Based Anticancer Therapeutics

“…The use of phosphine derivatives combined with metal atoms on the surface of metal nanoparticles can overcome toxicity problems by forming a hydrophilic, biocompatible and biodegradable coating on nanoparticles with stable binding [55]. Chattopadhyay S et al combined methyl iminodiacetic acid phosphate with cobalt oxide nanoparticles (PMIDA-CoO) and investigated the effects of this substance on human leukemia cell lines (Jurkat, K562 and KG1A cells) [56].…”

Continuous size fractionation of magnetic nanoparticles by using simulated moving bed chromatography

“…In the medical field, these include, for example, gene therapy [1] or cancer treatment by targeted drug delivery and magnetic hyperthermia, since the use of spatially focused magnetic fields in combination with functionalized MNPs allows to provide unique specificity to certain therapies [2][3][4][5][6]. Furthermore, a promising application as a contrast agent in MRI diagnoses is apparent [7][8][9]. On the technical side, MNPs are increasingly used for sensing [10], magnetic bearings [11], waste water treatment [12,13] and separation techniques [14].…”