Pnd125 - The Association Between Utilities and Disease Severity for Parkinson’s Disease: A Systematic Literature Review

Chandler, C.; Alvarez, Piedad; Folse, H.; Ward, Alexandra

doi:10.1016/j.jval.2018.09.2090

Cited by 1 publication

(2 citation statements)

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“…For example, the costs for hospital stays were based on official statistics for all PD patients for the 11 patients who stated a hospital stay but no length of stay. Likewise, 10 patients had up to 24 h of informal care, but these were conservatively assumed to be a maximum of 16 h to allow for caregiver In a systematic literature review, 26 which identified studies that evaluated patient utility measures according to PD severity, the authors concluded that the majority of the identified studies were based on small sample sizes in higher-severity health states.…”

Section: Discussionmentioning

confidence: 99%

“…In a systematic literature review, 26 which identified studies that evaluated patient utility measures according to PD severity, the authors concluded that the majority of the identified studies were based on small sample sizes in higher‐severity health states. In a Swedish setting, a recently published study based on PARKreg investigated utility values (estimated from the UK value set) by health states based on H&Y and ‘off‐time’ 27 .…”

Section: Discussionmentioning

confidence: 99%

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Quality of life and resource utilization‐Swedish data from the Care of Late‐Stage Parkinsonism (CLaSP) study

Norlin

Hjalte

Kruse

et al. 2022

Acta Neuro Scandinavica

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Netherlands: 733051003). The authors had full independence regarding data collection, manuscript preparation, decision to publish, study design, interpretation and analysis Background: Few studies have investigated the health-related quality of life (HRQoL), resource use and costs in patients with late-stage Parkinson's disease (PD), and data from the Swedish setting are scarce.Objectives: First, we analyse the HRQoL in late-stage PD in Sweden. Second, we analyse the resource use and costs per severity level. Third, we analyse the relationship between costs and physician-and patient reported-outcome measures. Materials and methods:The study was based on Swedish data from the Care of Late-Stage Parkinsonism (CLaSP) study. The costs of healthcare contacts, drugs, formal and informal care, and productivity loss were collected over three months. Assessments at baseline were used for outcomes (EQ-5D, Hoehn and Yahr (H&Y), Schwab and England Scale, Unified Parkinson's Disease Rating Scale subscales (UPDRS) and Non-Motor Symptoms Scale (NMSS)). Costs were estimated in € 2016. Results:In total, 106 patients were included. The mean EQ-5D score in the total group was 0.24 (±0.33). The mean total cost excluding informal care per patient in the three-month period was approximately €14,097 (BCa 95% CI €12,007 and €16,039).Professional care accounted for the largest share (75 percent) of the total costs. The EQ-5D, H&Y, Schwab and England Scale, and NMSS were statistically significant predicting factors for total costs. Conclusion:Patients with late-stage PD are a vulnerable patient group that is costly to society and the impairment in patients' HRQoL is immense. Thus, healthcare decision-makers should optimize the organization and provision of healthcare for these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%