Pneumatosis intestinalis in children with leukaemia: Report of three cases

Galal, Omar; Osse, G.; Weigel, Wade; Gahr, Manfred

doi:10.1007/bf00441178

Cited by 9 publications

(8 citation statements)

References 5 publications

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“…That patient had received vincristine, daunorubicin, thioguanine, and cytarabine. The diagnosis was made with plain radiographs and the pneumatosis resolved with antibiotics [69]. There appears to be insufficient evidence to guide the management of pneumatosis intestinalis in pediatric patients with AML.…”

Section: Other Conditionsmentioning

confidence: 99%

Gastrointestinal complications in children with acute myeloid leukemia

Gray¹,

Ooi²,

Tran

et al. 2010

Leukemia & Lymphoma

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Gastrointestinal complications in pediatric acute myeloid leukemia (AML) have not been systematically described in the literature. Our objective was to describe complications related to the small and large bowel in children with AML. Literature searches were conducted of Ovid Medline from 1950 to November 2009 and EMBASE from 1980 to November 2009. We included any study design that described gastrointestinal complications in children and/or adults with AML. Common gastrointestinal complications were typhlitis and enterocolitis. Less common complications included appendicitis, pneumatosis intestinalis, and perianal infections. Both leukemia infiltration and intensive chemotherapy likely play a role in the etiology of these conditions. There is a paucity of carefully conducted studies that describe the natural history of typhlitis and enterocolitis and evidence is needed to help guide the management of gastrointestinal complications. Gastrointestinal complications are relatively common in children with AML. Conduction of carefully performed cohort studies is needed to better understand the spectrum of symptoms and expected consequences of gastrointestinal complications. Randomized trials are required to develop evidence-based guidelines for the management of gastrointestinal complications in pediatric AML.

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Section: Other Conditionsmentioning

confidence: 99%

Gastrointestinal complications in children with acute myeloid leukemia

Gray¹,

Ooi²,

Tran

et al. 2010

Leukemia & Lymphoma

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“…Reports of successful treatment of PI in adults [13][14][15][16][17] and children 8,18 with metronidazole led to its use in our patient. This patient had had loose stools for so long that it had become "normal" for him and was rarely discussed at his periodic visits.…”

Section: Discussionmentioning

confidence: 86%

Medication-induced Pneumatosis Intestinalis

Duncan¹,

Barton

Eicher³

et al. 1997

Pediatrics

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“…It has been reported that decreasing the total amount of sorbitol is the first step in the treatment of PI [6,12]. Metronidazole is effective for treatment of both adults and children with PI [14][15][16]. Antibiotics for prevention and treatment of necrotizing enterocolitis are also important with clinical correlation.…”

Section: Discussionmentioning

confidence: 97%