Pneumocandin B0-imprinted Polymer Using Surface-imprinting Technique for Efficient Purification of Crude Product

Abstract

In this work, we prepared surface molecularly imprinted polymer (MIP) for selective recognition of pneumocandin B0 (PNB0). Methacrylic acid (MAA) was first grafted onto silica gel particles (SiO2) in the manner of "grafting from" by using 3-methacryloxypropyl trimethoxysilane as intermedium, and then PNB0 molecules were imprinted on the surface of the obtained particles in the presence of ethylene glycol diglycidyl ether as the cross-linker. The prepared MIP-PMAA/ SiO2 was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and thermo-gravimetric analysis, which confirmed the successful grafting of MAA onto SiO2 and the grafting degree was calculated to be 12.50 wt%. The binding properties of the products were investigated and it is found that the binding process of PNB0 followed the pseudo-second-order kinetic model. The as-prepared material also displays relatively quick adsorption kinetics and decent recognition affinity toward the template over its structurally related compound.

Synthesis and Characterizations of Molecularly Imprinted Polymer of Atrazine: Removal of Atrazine from Aqueous Samples

“…It was calculated that the selectivity coefficient or K sel value of ATZ was 2.50, much higher than the K sel value of AME of 0.90, resulting in a relative selectivity coefficient ( k’ ) of 2.77. A relative selectivity coefficient larger than 1.00 suggested that the synthesized polymers had good molecular recognition [73] . This also showed that the synthesized MIP (2VP) was more selective towards ATZ, the target molecule as compared to AME, the competitive compound.…”

“…A relative selectivity coefficient larger than 1.00 suggested that the synthesized polymers had good molecular recognition. [73] This also showed that the synthesized MIP (2VP) was more selective The successful imprinting process of MIP significantly contributed to its selectivity towards ATZ, demonstrating remarkable recognition ability despite the minimal structural differences among the competitive compounds, thus highlighting the combined influence of shape and size complementarity alongside analyte-functional group interactions within the three-dimensional polymer network. [33]…”

Purification of Andrographolide Methanolic Extract Using Molecularly Imprinted Polymer Prepared by Precipitation Polymerization

“…The performance of MIP and NIP were evaluated by determining the imprinting and selectivity factors calculated by Equations ( 2) and (3). Quercetin was chosen as a comparison compound for determining the selectivity factor, which was evaluated by comparing the imprinting factor of MIP to that of andrographolide and quercetin [10,[24][25][26].…”

“…Bulk polymerization was the first free radical method used to prepare MIP, but it has several drawbacks, such as, requiring grinding and sieving as post-treatment leads to multiple binding sites, time-consuming, varying size and shape, as well as deeply embedded recognition sites which decrease the accessibility of target molecules. Other methods have been developed to overcome these drawbacks, namely suspension, precipitation, and polymerization in heterogeneous systems [6][7][8][9][10].…”

Molecularly Imprinted Materials in Analytical Chemistry

“…Methacrylic acid MAA was first grafted onto silica-gel particles in the manner of "grafting from" by using 3-methacryloxypropyl trimethoxysilane as an intermedium, and then PNB0 molecules were imprinted on the surface of the obtained particles in the presence of ethylene glycol diglycidyl ether as a cross-linker. 8 The hybrid particle showed relatively quick adsorption kinetics and decent recognition affinity toward the template over its structurally related compounds. Feng et al indicated novel magnetic imprinted composites through a facile method using a sulfadimethoxines template.…”