“…Both herpesvirus II and papillomavirus (causing condylomata acuminata) are possible candidates by virtue of their association with cervical cancer (Graham et al, 1982;Reid et al, 1982;Hulka, 1982). Condylomata have been described in case reports as apparent precursors to squamous carcinomas of the anus (Shelly & Wood, 1981;Prasad & Abcarian, 1980;Siegel, 1962;Oriel & Whimster, 1971 Since the excess risk for anal cancer in single males exists for older as well as younger men and has been observed over at least the last 10 years, and since squamous tumours such as anal carcinoma probably require several years to develop, it seems unlikely that anal cancer is related to AIDS (CDC, 1982;Gottlieb et al, 1981). Nonetheless, we cannot completely rule out this possibility.…”