Pneumocystis carinii pneumonia presenting as a single pulmonary nodule

Bier, Simone; Halton, Kathleen P.; Krivisky, B; Leonidas, J R

doi:10.1007/bf02387509

Cited by 18 publications

(4 citation statements)

References 3 publications

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“…Nodular opacities in Pneumocystis jirovecii ( P. jirovecii ) infection are related with granulomatous response to PJP infection on histopathologic examination that is an uncommon form of Pneumocystis infection. Solitary pulmonary nodule in patients with PJP infection is very rare and only 3 cases have been reported in the English literature (4, 5, 6). In addition, imaging findings of single nodular opacities in lymphoma patients can mimic lymphoma involvement of the lung or other infectious lesions.…”

Section: Introductionmentioning

confidence: 99%

Single Nodular Opacity of GranulomatousPneumocystis JiroveciiPneumonia in an Asymptomatic Lymphoma Patient

2015

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The radiologic findings of a single nodule from Pneumocystis jirovecii pneumonia (PJP) have been rarely reported. We described a case of granulomatous PJP manifesting as a solitary pulmonary nodule with a halo sign in a 69-year-old woman with diffuse large B cell lymphoma during chemotherapy. The radiologic appearance of the patient suggested an infectious lesion such as angioinvasive pulmonary aspergillosis or lymphoma involvement of the lung; however, clinical manifestations were not compatible with the diseases. The nodule was confirmed as granulomatous PJP by video-assisted thoracoscopic surgery biopsy.

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Section: Introductionmentioning

confidence: 99%

Single Nodular Opacity of GranulomatousPneumocystis JiroveciiPneumonia in an Asymptomatic Lymphoma Patient

2015

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“…Solitary pulmonary nodules due to Pc have been documented prior to our report in AIDS [2,4] and non-AIDS patients [3,7,12]. However, noncavitating lesions of the encountered size confined to the lower lobe of one lung have not been observed before.…”

Section: Discussionmentioning

confidence: 69%

A novel variety of atypical pneumocystis carinii infection after long-term prophylactic pentamidine inhalation in an AIDS patient: large lower lobe pneumocystoma

et al. 1993

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Atypical pulmonary manifestations of Pneumocystis carinii infection and fair numbers of extrapulmonary and disseminated infections have lately been documented in patients with human immunodeficiency virus infection treated prophylactically with inhalative pentamidine. We report the case of a 32-year-old homosexual patient who was assessed for complaints of night sweats, weight loss, and progressive malaise. The patient denied any respiratory tract symptoms such as cough, sputum production, pleuritic chest pain, or shortness of breath. Chest X-ray revealed two large round noncavitating lesions in the lower lobe of the right lung. Pneumocystomas were diagnosed by fine-needle aspiration. A 3-week course of intravenous high-dose cotrimoxazole resulted in amelioration of symptoms but no change in the radiographic appearance of the pulmonary lesions. Four months later the patient is alive and stable and is being treated with pentamidine inhalation of 300 mg per 2 weeks and two tablets of pyrimethamine sulfadoxine per week.

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“…A significant minority (17%) have diffuse infiltrates without nodules [10]. Two studies have reported the appearance of nodules on radiographs and CT scans a few days after a negative study, showing that these granulomas can develop quickly [13], [17]. Enlarging nodules over weeks to months was a consistent finding in multiple studies in patients who were not being treated adequately [18], [19], [20].…”

Section: Discussionmentioning

confidence: 86%

High-resolution CT, histopathologic, and clinical features of granulomatous pneumocystis jiroveci pneumonia

Dako

Kako

Jhala

et al. 2019

Radiology Case Reports

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Although pneumocystis jiroveci pneumonia was historically associated with HIV/AID patients, there is a recent shift in demographics with increasing incidence in patients with hematologic malignancies and transplants. A granulomatous response to pneumocytis jiroveci infection is uncommon and most commonly presents as multiple randomly distributed nodules on chest imaging. Granulomatous pneumocytis jiroveci pneumonia presents with similar clinical manifestations as typical pneumocytis pneumonia but is usually not detected by bronchoalveolar lavage and may require biopsy for a definitive diagnosis. For this reason, the radiologist may be the first provider to suggest this diagnosis and guide management.

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Pneumocystis carinii pneumonia presenting as a single pulmonary nodule

Cited by 18 publications

References 3 publications

Single Nodular Opacity of GranulomatousPneumocystis JiroveciiPneumonia in an Asymptomatic Lymphoma Patient

Single Nodular Opacity of GranulomatousPneumocystis JiroveciiPneumonia in an Asymptomatic Lymphoma Patient

A novel variety of atypical pneumocystis carinii infection after long-term prophylactic pentamidine inhalation in an AIDS patient: large lower lobe pneumocystoma

High-resolution CT, histopathologic, and clinical features of granulomatous pneumocystis jiroveci pneumonia

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