Pneumonia

Howie, Stephen R. C.; Hamer, Davidson H.; Graham, Stephen M.

doi:10.1016/b978-0-12-803678-5.00334-9

Cited by 4 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A ventilláció-asszociált tüdőgyulladás a betegek közel egynegyedénél alakult ki (24,29%), mely érték megegyezik a szakirodalomban leírtakkal, miszerint a VAT incidenciája 10-30%-ra tehető intenzív terápiás osztályon ápolt betegeknél [13]. Esetünkben korai és késő VAT eltérő arányban alakult ki.…”

Section: Megbeszélésunclassified

Incidence of multidrug-resistant bacteria in tracheal secretions from critically ill patients in the intensive care unit

Berki

Csongor

Székely

et al. 2020

Bulletin of Medical Sciences

View full text Add to dashboard Cite

Ventilator-associated pneumonia is a severe nosocomial infection that affects the disease course of critically ill patients. Awareness of potential pathogens is essential for prevention, early detection, and proper treatment, as well. In this retrospective cross-sectional study, we investigated the tracheal secretions collected from critically ill patients with the aim to detect the occurrence of multidrug-resistant bacteria. We examined the bacteriological culture results of the tracheal secretions of the patients hospitalized at the Intensive Care Unit of Tîrgu Mureș Emergency Clinical County Hospital between 1st November 2017 and 31st January 2018. Admission diagnoses and comorbidities were recorded, and white blood cell counts were monitored. We determined the quality of the lower respiratory samples by microscopic examination and the results of the microbiological tests, taking into account the germ count of pathogens and the antibiotic-resistance pheno-type. During the three months, 194 samples were received from 107 patients for bacteriological examination. After the first sample collection 34 (31.77%) tracheal secretions were positive for pathogens, while in the remaining samples normal upper respiratory bacterial flora was found. From the 34 positive samples, 22 were colonizing pathogens and 30 were isolated in a clinically significant amount. Predominantly Staphylococcus aureus (n=14; 26.9%), Klebsiella pneumoniae (n=9; 17.3%), Escherichia coli (n=8.1%) and other Gram-negative bacteria (n=21; 40.4%) were identified. Among these strains 38 (73.07%) were not multidrug-resistant. The rate of positivity of individual sampling showed a positive correlation with the average duration of hospital stay (p=0.0016; r=0.8740). A total of 26 patients developed early-onset or late-onset ventilator-associated pneumonia. Potential risk factors for infection with multidrug-resistant bacteria were found. We can conclude that recently admitted patients in the intensive care unit are rarely carriers of multidrug-resistant bacteria, but become colonized or infected with multidrug-resistant strains during long-term intensive care.

show abstract

Section: Megbeszélésunclassified

Incidence of multidrug-resistant bacteria in tracheal secretions from critically ill patients in the intensive care unit

Berki

Csongor

Székely

et al. 2020

Bulletin of Medical Sciences

View full text Add to dashboard Cite

show abstract

“…This number of deaths globally exceeds the deaths of malaria, tuberculosis, and HIV infection combined. Pneumonia can be caused by bacteria, viruses, and mycoplasma [1]. Klebsiella pneumoniae bacteria are capable of infecting and exacerbating patients with COVID-19 disease [2].…”

Section: Introductionmentioning

confidence: 99%

Molecular Dynamics, Prediction of Toxicity, and Interaction of the Active Compound Caesalpinia sappan on Essential Lipids Klebsiella pneumoniae

Putra¹,

Armin²,

Florida³

et al. 2021

Advances in Health Sciences Research

View full text Add to dashboard Cite

Pneumonia is the highest cause of death in the world. The presence of COVID-19 can worsen the patient's condition. One of the causes of pneumonia is Klebsiella pneumoniae. These bacteria can be resistant to antibiotics. In this case, an alternative treatment is needed. Caesalpinia sappan, based on pre-clinical trials, has an activity to be used as an antimicrobial. The activity predictions, molecular docking, and molecular dynamics simulations were performed using computational methods. The log P values were found in the range of 0.86-2.26. The molecular weights were in the range of 272.25-344.36 g/mol. All active compounds qualify with the Lipinski rule of 5. The lowest binding affinity value is -9.8 (kcal/mol), suggesting it can bind more strongly to the lipid from Klebsiella pneumoniae. Structure alert was obtained, namely catechol and aldehyde. The results of molecular dynamics of compound 7 in Klebsiella pneumonia protein got an eigenvalue of 5.186e-05. The active compound from Caesalpinia sappan is predicted to develop as a lipid inhibitor from Klebsiella pneumoniae. It has interaction such as Compound 7 has one hydrogen bond in the amino acid Trp46, one π-cation in Arg80, and one π-Sulfur bond in Met156.

show abstract

“…Com relação a PAH, esta tem sido a segunda causa mais comum de infecção nosocomial, sendo a antibióticoterapia inadequada ou tardia associada a maior mortalidade, com taxas podendo chegar até 50%. [22][23] Os microrganismos envolvidos incluem Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter spp, Acinetobacter spp e Staphylococcus aureus. 24 A principal preocupação na PAH e PAV se dá pelo aumento cada vez mais proeminente dos microrganismos multirresistentes, como Staphylococcus aureus resistente a meticilina (MRSA), que limita as opções de tratamentos e o encarecem.…”

Section: Introductionunclassified

Estratégias para superação da barreira do surfactante pulmonar para sucesso da terapia fotodinâmica antimicrobiana

Lima

View full text Add to dashboard Cite

Pneumonia is an infection characterized by inflammation of the alveoli that is filled with fluid or pus, making breathing and the passage of oxygen into the bloodstream difficult. This infection is among the main causes of morbidity and mortality, mainly due to the difficulty in finding effective treatments given the increase in the rate of antibioticresistant microorganisms. Antimicrobial Photodynamic Therapy (aPDT) presents itself as a potential alternative, due to its high antimicrobial efficiency and non-specific action acting on multiple molecular targets, selectivity to the treatment site and through noninvasive procedure. Studies carried out by our research group reported the efficiency and safety of a protocol for in vitro photoinactivation of Streptococcus pneumoniae, as well as the delivery of light and photosensitizer in an animal model. However, the reduction of microorganisms in vivo still presents challenges to be overcome, due to the presence of lung surfactant (LS), which traps photosensitizer (PS) molecules preventing them from interacting with the microbial target. In the present study, different approaches were used in order to optimize the antimicrobial response of aPDT using indocyanine green (ICG) in the presence of LS, where this FS was associated with perfluorocarbon and oxygen nanobubbles, in addition to the combination of aPDT with ultrasound. However, the most promising strategy consisted of the combination of ICG (10 µM) with the Gantrez AN-139 polymer (0.2% (w/v)), which showed high microbial reduction of S. pneumoniae concomitantly with nontoxicity for lung cell lines human fibroblast (MRC-9) and epithelial (A549), under same treatment conditions. The achieved results demonstrate the difficulties in developing protocols for lung disinfection and point to a possible solution for optimizing the antimicrobial response of aPDT for this purpose.

show abstract

Pneumonia

Cited by 4 publications

References 37 publications

Incidence of multidrug-resistant bacteria in tracheal secretions from critically ill patients in the intensive care unit

Incidence of multidrug-resistant bacteria in tracheal secretions from critically ill patients in the intensive care unit

Molecular Dynamics, Prediction of Toxicity, and Interaction of the Active Compound Caesalpinia sappan on Essential Lipids Klebsiella pneumoniae

Estratégias para superação da barreira do surfactante pulmonar para sucesso da terapia fotodinâmica antimicrobiana

Contact Info

Product

Resources

About