Pneumonia due to multidrug-resistant Leclercia adecarboxylata

Eiland, Edward H.; Siddiqui, Hafsa; Goode, Ann Marie; Leeth, Shay D.

doi:10.2146/ajhp120525

Cited by 14 publications

(10 citation statements)

References 8 publications

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“…19 Kasus pneumonia yang disebabkan oleh bakteri L. adecarboxylata terhitung jarang, tetapi pernah dilaporkan. 20 Hasil kultur tidak berhubungan dengan keparahan pneumonia. Hal tersebut mungkin disebabkan oleh bakteri kontaminan dan riwayat pemberian antibiotik.…”

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Hubungan Kadar Prokalsitonin dan Kultur Bakteri dengan Tingkat Keparahan Pneumonia pada Anak

Suwarto

Fadlyana

Kartasasmita

2016

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Latar belakang. Di negara berkembang, pneumonia merupakan penyebab utama kesakitan dan kematian pada bayi dan balita. Penelitian sebelumnya menemukan prokalsitonin dapat menggambarkan keparahan pneumonia pada anak. Dilaporkan juga kultur bakteri positif lebih sering ditemukan pada pneumonia berat dengan komplikasi. Tujuan.Menentukan hubungan kadar prokalsitonin dan kultur bakteri dengan tingkat keparahan pneumonia.Metode. Penelitian potong lintang yang dilaksanakan dari bulan September 2014 hingga Januari 2015 di RSUP Dr. Hasan Sadikin Bandung. Dilibatkan 61 anak berusia 1 bulan hingga 5 tahun. Subjek terdiri atas 30 anak pneumonia berat dan 31 anak pneumonia. Pemeriksaan prokalsitonin dilakukan dengan Elecsys BRAHMS PCT. Kultur darah diperiksa dengan mesin BACTEC 9050, jika hasilnya positif bakteri kemudian dibiakkan dalam media agar McConkey atau agar darah. Data hasil penelitian diuji dengan Mann Whitney dan chi-square. Hasil.Nilai median PCT pneumonia berat 0,69 ng/mL dan pneumonia 0,075 ng/mL, dengan nilai p<0,001. Hasil kultur positif ditemukan 5 dari 30 pada pneumonia berat dan 10 dari 31 pada pneumonia, dengan nilai p=0,157.Kesimpulan. Keparahan pneumonia berhubungan dengan kadar prokalsitonin dan tidak berhubungan dengan hasil kultur bakteri. Sari Pediatri2015;17(4):261-6.

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Hubungan Kadar Prokalsitonin dan Kultur Bakteri dengan Tingkat Keparahan Pneumonia pada Anak

Suwarto

Fadlyana

Kartasasmita

2016

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“…Another case of pneumonia due to multidrug‐resistant L. adecarboxylata was also described (Eiland et al . ). Isolation of L. adecarboxylata from an immunocompetent paediatric patient was reported (Grantham et al .…”

Section: Resultsmentioning

confidence: 97%

“…Another case of pneumonia due to multidrug‐resistant L. adecarboxylata was described (Eiland et al . ). We report the isolation of Leclercia species probably for the first time from an animal clinical case and reviewed the literature on its occurrence.…”

Section: Resultsmentioning

confidence: 97%

Isolation and characterization of multidrug-resistant Leclercia species from animal clinical case

Choudhary

Bhoyar

et al. 2017

Lett Appl Microbiol

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Significance and Impact of the Study: Leclercia adecarboxylata is a rarely reported human pathogen. We report here the case from bovine suffering from respiratory distress; the sample yielded Leclercia species as polymicrobial culture. The isolate was found to be multidrug resistant and evidenced for uncertain clinical relevance and could act as hidden source of public health hazard. The limited literature available on this organism is reviewed, and the potential implications of findings are discussed. To the best of our knowledge, this is the first report of isolation and characterization of multidrug-resistant Leclercia species from animal clinical case from India. AbstractLeclercia adecarboxylata, a Gram-negative bacillus of family Enterobacteriaceae, is an uncommonly identified pathogen isolated from environmental and clinical specimens. Most of the human infections are polymicrobial and commonly occur in immunocompromised hosts, although nosocomial infections in immunocompetent hosts have been documented. Here, we describe the case of isolation of Leclercia species as polymicrobial infection from bovine suffering from respiratory distress in Chhattisgarh state of India. The isolates were identified by their phenotypes, 16S rDNA sequencing and MALDI-TOF-MS. The isolate was found to be resistant to aminoglycosides and fluoroquinolone antibiotics and intermediate resistant to cephalosporins and evidenced for uncertain clinical relevance and could act as hidden source of public health hazard.

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“…Prior reports document this bacterium in immunocompromised patients [ 3 – 8 ]; however, recently there have been limited reports in immunocompetent patients [ 9 , 10 ] in addition to the pediatric population [ 5 , 8 , 11 ]. Most cases report the bacteria with excellent susceptibility to antibiotics, as was the case for this isolate; however, resistant strains have been found [ 12 ]. Even catheter-associated infection with Leclercia adecarboxylata has been treated successfully with antibiotics alone without catheter removal [ 13 ].…”

Section: Discussionmentioning

confidence: 97%

Leclercia adecarboxylataMusculoskeletal Infection in an Immune Competent Pediatric Patient: An Emerging Pathogen?

Grantham

Funk

Schoenecker

2015

Case Reports in Orthopedics

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Case. An immune competent pediatric patient presented with a persistent lower extremity infection with Leclercia adecarboxylata after a penetrating injury. This case report details the presentation, clinical course, and treatment. Conclusion. Leclercia adecarboxylata has increasing reports in immunosuppressed and adult patients with musculoskeletal infection. This case now indicates that Leclercia adecarboxylata is a potential pathogen in immune competent children in musculoskeletal tissue.

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Pneumonia due to multidrug-resistant Leclercia adecarboxylata

Cited by 14 publications

References 8 publications

Hubungan Kadar Prokalsitonin dan Kultur Bakteri dengan Tingkat Keparahan Pneumonia pada Anak

Hubungan Kadar Prokalsitonin dan Kultur Bakteri dengan Tingkat Keparahan Pneumonia pada Anak

Isolation and characterization of multidrug-resistant Leclercia species from animal clinical case

Leclercia adecarboxylataMusculoskeletal Infection in an Immune Competent Pediatric Patient: An Emerging Pathogen?

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