Pneumonia in Childhood and Impaired Lung Function in Adults: A Longitudinal Study

Chan, Jim Yee Him; Stern, Debra A.; Guerra, Stefano; Wright, Anne L.; Morgan, Wayne J.; Martínez, Fernando D.

doi:10.1542/peds.2014-3060

Cited by 163 publications

(150 citation statements)

References 38 publications

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“…Low lung function in early life has been shown to track through childhood and into adulthood (3,4); furthermore, children born with low lung function have an increased risk of LRTI or wheezing illnesses in childhood (5)(6)(7)(8)(9)(10). LRTI in infancy has been associated with reduced lung function in later childhood and adulthood (11)(12)(13)(14). However, the sparse data from longitudinal studies of lung function in high-income settings suggest that the effect of respiratory tract illness on later lung function may be mediated through reduced lung function before the disease episode (9,10).…”

Section: Measurements and Mainmentioning

confidence: 99%

Lung Function in African Infants in the Drakenstein Child Health Study. Impact of Lower Respiratory Tract Illness

Gray

Turkovic

Willemse

et al. 2017

Am J Respir Crit Care Med

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Rationale: Lower respiratory tract illness is a major cause of childhood morbidity and mortality. It is unknown whether infants are predisposed to illness because of impaired lung function or whether respiratory illness reduces lung function.Objectives: To investigate the impact of early life exposures, including lower respiratory tract illness, on lung function during infancy.Methods: Infants enrolled in the Drakenstein child health study had lung function at 6 weeks and 1 year. Testing during quiet natural sleep included tidal breathing, exhaled nitric oxide, and multiple breath washout measures. Risk factors for impaired lung health were collected longitudinally. Lower respiratory tract illness surveillance was performed and any episode investigated. Measurements and MainResults: Lung function was tested in 648 children at 1 year. One hundred and fifty (29%) infants had a lower respiratory tract illness during the first year of life.Lower respiratory tract illness was independently associated with increased respiratory rate (4%; 95% confidence interval [CI], 1.01-1.08; P = 0.02). Repeat episodes further increased respiratory rate (3%; 95% CI, 1.01-1.05; P = 0.004), decreased tidal volume (21.7 ml; 95% CI, 23.3 to 20.2; P = 0.03), and increased the lung clearance index (0.13 turnovers; 95% CI, 0.04-0.22; P = 0.006) compared with infants without illness. Tobacco smoke exposure, lung function at 6 weeks, infant growth, and prematurity were other independent predictors of lung function at 1 year.Conclusions: Early life lower respiratory tract illness impairs lung function at 1 year, independent of baseline lung function. Preventing early life lower respiratory tract illness is important to optimize lung function and promote respiratory health in childhood.

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Section: Measurements and Mainmentioning

confidence: 99%

Lung Function in African Infants in the Drakenstein Child Health Study. Impact of Lower Respiratory Tract Illness

Gray

Turkovic

Willemse

et al. 2017

Am J Respir Crit Care Med

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“…Longitudinal studies show that childhood pneumonia is associated with asthma, and with impaired lung function, which persists into adulthood [21]. The study region has one of the highest LRTI hospitalisation rates in the US [1,22], with median cost of LRTI hospitalisation for respiratory syncytial virus estimated at $22,323 [23].…”

Section: Discussionmentioning

confidence: 99%

Impact of home remediation and household education on indoor air quality, respiratory visits and symptoms in Alaska Native children

Singleton

Salkoski

Bulkow³

et al. 2018

International Journal of Circumpolar Health

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Alaska Native children experience high rates of lower respiratory tract infections (LRTIs) and lung conditions, which are associated with substandard indoor air quality (IAQ). We conducted an intervention of home remediation and education to assess the impact on IAQ, respiratory symptoms and LRTI visits. We enrolled households of children 1–12 years of age with lung conditions. Home remediation included improving ventilation and replacing leaky woodstoves. We provided education about IAQ and respiratory health. We monitored indoor airborne particles (PM2.5), CO2, relative humidity and volatile organic compounds (VOCs), and interviewed caregivers about children’s symptoms before, and for 1 year after intervention. We evaluated the association between children’s respiratory visits, symptoms and IAQ indicators using multiple logistic regression. A total of 60 of 63 homes completed the study. VOCs decreased (coefficient = −0.20; p < 0.001); however, PM2.5 (coeff. = −0.010; p = 0.89) did not decrease. Burning wood for heat, VOCs and PM2.5 were associated with respiratory symptoms. After remediation, parents reported decreases in runny nose, cough between colds, wet cough, wheezing with colds, wheezing between colds and school absences. Children had an age-adjusted decrease in LRTI visits (coefficient = −0.33; p = 0.028). Home remediation and education reduced respiratory symptoms, LRTI visits and school absenteeism in children with lung conditions.

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“…Severe early-onset bronchiolitis is associated with an increased risk of asthma, especially after rhinovirus or RSV bronchiolitis, and an increased risk of asthma may persist into early adulthood [61,62]. An undefined aspect is up to which point early bronchiolitis in infancy damages normal lung development and predisposes to subsequent bronchospasm or even where certain infants have a preexisting aberration of immune response or airway function that predisposes them to severe bronchiolitis and recurrent bronchospasm [63].…”

Section: Bronchiolitis and Asthmamentioning

confidence: 99%

Bronchiolitis in adult: A review

Alvarado¹,

Arce²

2017

Clin Res Trials

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Few diseases have a greater effect on the health of young children than viral respiratory illness of lower tract. This does not happen in adults, possibly due to the different states of activation and expression of the innate immune response and acquired immune responses in these two age groups. Bronchiolitis is a general term used to describe non-specific inflammatory injury that primarily affects the small airways and generally limits the extent to interstice. In the adult clinic, conventional and high-resolution radiology and respiratory functional studies are suggestive of the diagnosis but the etiology usually requires tissue. For this reason, in this work, although there are clinical and radiological classifications, we will use the histologic classification. The goal is a simple, concise and updated monograph issue discussing the different types of adult bronchiolitis, pathophysiology, diagnosis and current therapeutic options.

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Pneumonia in Childhood and Impaired Lung Function in Adults: A Longitudinal Study

Abstract: BACKGROUND: Diminished lung function and increased prevalence of asthma have been reported in children with a history of early lower respiratory illnesses (LRIs), including pneumonia. Whether these associations persist up to adulthood has not been established.

Cited by 163 publications

References 38 publications

Lung Function in African Infants in the Drakenstein Child Health Study. Impact of Lower Respiratory Tract Illness

Lung Function in African Infants in the Drakenstein Child Health Study. Impact of Lower Respiratory Tract Illness

Impact of home remediation and household education on indoor air quality, respiratory visits and symptoms in Alaska Native children

Bronchiolitis in adult: A review

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