PO.7.151 The relationship between health-related quality of life and disease activity in sle patients

Abstract

Proportions of patients reporting problems were greater among obese versus normal-weighted patients regarding all EQ-5D dimensions (table 1). Post-intervention, similar results were seen for both the pre-obese patients and the obese patients, in comparison with normalweighted patients (table 2). In multivariable logistic regression analysis, obesity was associated with unfavourable HRQoL in all EQ-5D-3L dimensions at baseline (P<0.05 for all), showing the strongest association with mobility (OR: 2.09; 95% CI: 1.57-2.79; P<0.001), and pre-obesity with problems regarding mobility (OR: 1.42; 95% CI: 1.11-1.82; P=0.005). Post-intervention, obesity was associated with problems in mobility and pain/discomfort, and pre-obesity with problems in mobility and self-care (P<0.05 for all). Conclusions Our study corroborates known associations between high BMI and HRQoL impairments. Obesity appears to negatively impact on mobility and contribute to pain despite therapy. Investigation of whether weight control can improve HRQoL in a prospective setting is warranted.