Proportions of patients reporting problems were greater among obese versus normal-weighted patients regarding all EQ-5D dimensions (table 1). Post-intervention, similar results were seen for both the pre-obese patients and the obese patients, in comparison with normalweighted patients (table 2). In multivariable logistic regression analysis, obesity was associated with unfavourable HRQoL in all EQ-5D-3L dimensions at baseline (P<0.05 for all), showing the strongest association with mobility (OR: 2.09; 95% CI: 1.57-2.79; P<0.001), and pre-obesity with problems regarding mobility (OR: 1.42; 95% CI: 1.11-1.82; P=0.005). Post-intervention, obesity was associated with problems in mobility and pain/discomfort, and pre-obesity with problems in mobility and self-care (P<0.05 for all). Conclusions Our study corroborates known associations between high BMI and HRQoL impairments. Obesity appears to negatively impact on mobility and contribute to pain despite therapy. Investigation of whether weight control can improve HRQoL in a prospective setting is warranted.

Conclusions Serum IFNa2 levels measured by Simoa, but not the type-I IFN gene signature, are associated with disease activity scores and characterize disease activity states in cSLE patients. Hence, this technique has the potential to be implemented in clinical practice.

and the process of acceptance, and then all that is required in daily life'). The core themes that emerged from the LVC and comments emcompassed: disease knowledge, support network, coping strategies, healthcare system, and self-management (Figure 1). Conclusions Understanding these aspects is necessary to address the educational needs of people with lupus. A healthpromoting curriculum aiming to support lupus patients' selfmanagement should consider the critical role that the knowledge plays to move forward into effective personal and collective actions. Epistemic justice is also a primary principle to conduct health policies that seek the full integration of these patients into the society.