Po19-525 Elevated Serum MMP-8 Concentrations in Men With Subclinical Atherosclerosis Predict CVD Death

Gingival crevicular fluid and serum matrix metalloproteinase‐8 and tissue inhibitor of matrix metalloproteinase‐1 levels in renal transplant patients undergoing different immunosuppressive therapy

“…In general, the prominent changes in serum MMP-8 and TIMP-1 levels as well as MMP-8/TIMP-1 have been reported recently in systemically healthy patients with severe forms of periodontitis , or patients with diabetes or atherosclerosis patients with or without periodontitis (Safkan-Seppala et al 2006, Soder et al 2006, Tuomainen et al 2007). Regarding serum of immunosuppressive patients, here, we found significant but modest changes in serum MMP-8, TIMP-1 levels and MMP-8/TIMP-1.…”

“…It can be hypothesized that altered GCF and serum levels of MMP-8 and TIMP-1, and the MMP-8/TIMP-1 ratio in GCF are related to the CsA-induced GO. Furthermore, especially serum MMP-8 and TIMP-1 levels may reflect systemic chronic inflammatory and immune responses (Soder et al 2006, Tuomainen et al 2007). Therefore, the aim of the present study was to investigate the presence of GCF and serum MMP-8 and TIMP-1 levels in renal transplant patients receiving CsA therapy and having GO, patients receiving CsA therapy and having no GO and patients receiving tacrolimus therapy.…”

“…The findings from these studies suggest that the effect of CsA on MMP production is unclear. Furthermore, especially serum MMP-8 and TIMP-1 levels may reflect systemic chronic inflammatory and immune responses (Soder et al 2006, Tuomainen et al 2007). Also, the levels of MMP-8 and TIMP-1 in patients under tacrolimus therapy have not been investigated so far.…”

Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation

“…13 Furthermore, especially serum MMP-8 and TIMP-1 levels may reflect systemic chronic inflammatory and immune responses. [15][16][17] During the onset and progression of periodontal disease, at cellular level, increased secretion of cytokines and inflammatory markers such as interleukin-6 (IL-6), interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) results in the release of MMPs when gingival health progresses to disease. 18 It was recently demonstrated that PCOS is particularly associated with the severity of gingival inflammation especially on the proinflammatory cytokines such as IL-6, IL-17, TNF-α.…”