Podocyte infolding glomerulopathy after 25 years of clinical remission of lupus nephritis in a patient with systemic lupus erythematosus: A case report and review of literature

Abstract

Podocyte infolding glomerulopathy (PIG) is a rare pathological finding that has gained more recognition recently. Most of the reported cases have been associated with connective tissue diseases especially systemic lupus erythematosus (SLE). Here we report the first case of Infolding Glomerulopathy associated with SLE in the Middle East.

A Case of Podocytic Infolding Glomerulopathy with Diabetes Mellitus, Nephrotic Range Proteinuria and Positive Anti-PLA2R in Serum

“…Using the electron microscopy, PIG has been categorized into three classes based on the typical changes in the glomerular basement membrane (GBM). Class A is characterized by primarily podocyte infolding only; class B contains microstructures in the GBM and primary podocyte infolding, whereas class C is defined only by the presence of microstructures in the GBM [4,5]. It seems that in those 44 cases of PIG that have been reported globally, an autoimmune disease coexists PIG presents great heterogeneity in terms of coexisting diseases, immunological profile and histopathological pattern.…”