Biomimetics Learning From Nature 2010
DOI: 10.5772/8772
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Podophyllotoxin and Antitumor Synthetic Aryltetralines. Toward a Biomimetic Preparation

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“…Podophyllotoxin (Figure 3) has long been known to possess anti-mitotic activity with early clinical trials indicating its high efficacy. Unfortunately, this compound is known to be toxic limiting its direct application as a drug [12]. To solve the problem of toxicity, several modifications were made to the podophyllotoxin structure in hope of obtaining compounds with low toxicity but retain the desired activities of the parent compound.…”
Section: Phenolic Compoundsmentioning
confidence: 99%
“…Podophyllotoxin (Figure 3) has long been known to possess anti-mitotic activity with early clinical trials indicating its high efficacy. Unfortunately, this compound is known to be toxic limiting its direct application as a drug [12]. To solve the problem of toxicity, several modifications were made to the podophyllotoxin structure in hope of obtaining compounds with low toxicity but retain the desired activities of the parent compound.…”
Section: Phenolic Compoundsmentioning
confidence: 99%