Podophyllotoxin Aza-Analogue, A Novel DNA Topoisomerase II Inhibitor.

Iida, Akira; Kano, Masahiro; Kubota, Yoshihiro; Koga, Kenji; Tomioka, Kiyoshi

doi:10.1248/cpb.48.486

Cited by 14 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2-azapodophyllotoxins could inhibit TOPO-II in malignant cells. Different from some natural occurring or semi-synthesized podophyllotoxins, an oxidized E-ring would be an essential motif of 2-aza-podophyllotoxins analogues (178) [150]. 4-aza-4-deoxypodophyllotoxin showed potent cytotoxicity against P388 leukemia cells [151].…”

Section: Ring Cmentioning

confidence: 99%

Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins

et al. 2022

View full text Add to dashboard Cite

Plants containing podophyllotoxin and its analogues have been used as folk medicines for centuries. The characteristic chemical structures and strong biological activities of this class of compounds attracted attention worldwide. Currently, more than ninety natural podophyllotoxins were isolated, and structure modifications of these molecules were performed to afford a variety of derivatives, which offered optimized anti-tumor activity. This review summarized up to date reports on natural occurring podophyllotoxins and their sources, structural modification and biological activities. Special attention was paid to both structural modification and optimized antitumor activity. It was noteworthy that etoposide, a derivative of podophyllotoxin, could prevent cytokine storm caused by the recent SARS-CoV-2 viral infection.

show abstract

Section: Ring Cmentioning

confidence: 99%

Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Some of these compounds show as a potent endothelin-A selective receptor antagonist. On the other hand, biologically important disubstituted tetrahydroisoquinolines display β-adrenergic receptor antagonist, antitumor, , and antimicrobial activities.…”

mentioning

confidence: 99%

Copper Catalyzed One-Pot Three-Component Imination–Alkynylation–aza-Michael Sequence: Enantio- and Diastereoselective Syntheses of 1,3-Disubstituted Isoindolines and Tetrahydroisoquinolines

2019

View full text Add to dashboard Cite

An enantio- and diastereoselective syntheses of 1, 3-disubstituted isoindolines and tetrahydroisoquinolines via CuI-Pybox-diPh catalyzed one-pot imination–alkynylation–aza-Michael sequence has been reported. The three-component reaction produces one C–C and two C–N bonds sequentially with high yield (up to 92%), enantioselectivity (up to 99%), and diastereoselectivity (up to 9:1) in a single operation. Furthermore, the synthetic utility of the product has been demonstrated by LiAlH4 reduction of ester and hydrogenation of alkyne functionality without losing the stereoselectivity.

show abstract

CH Arylation of Saturated N ‐Heterocycles

Haldar

Mandal

Jana

2022

Handbook of CH-Functionalization

View full text Add to dashboard Cite

Saturated N ‐heterocycles having an aryl group are core structures of numerous natural products, pharmaceuticals, chiral catalysts, etc. Therefore, different strategies have been developed for the synthesis of arylated N ‐heterocycles. In contrast to multistep synthesis, the development of direct arylation of saturated N ‐heterocycles has become increasingly popular in recent years. This article summarizes the methods for the synthesis of arylated N ‐heterocycles through direct CH arylation of alicyclic amines.

show abstract

Podophyllotoxin Aza-Analogue, A Novel DNA Topoisomerase II Inhibitor.

Cited by 14 publications

References 0 publications

Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins

Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins

Copper Catalyzed One-Pot Three-Component Imination–Alkynylation–aza-Michael Sequence: Enantio- and Diastereoselective Syntheses of 1,3-Disubstituted Isoindolines and Tetrahydroisoquinolines

CH Arylation of Saturated N ‐Heterocycles

Contact Info

Product

Resources

About