Based on the actual working condition of the cycloidal gear on the RV reducer, the maximum normal contact load of gear tooth and mesh tooth pair for varied quantity of plus equidistant modification and minus radial-moving modification were analyzed. By considering the macroscopic geometry, the contact load, and the real tooth surface roughness and transient effect of the contact area between pinwheel and cycloidal gear, a mixed lubrication model was established. The effects of normal load, curvature radius at the meshing point, fillet radius, as well as the speed on the lubrication condition were discussed. The results suggest that load, fillet radius, and speed have different degrees of influence on the lubricating conditions while the change of curvature radius in a small range has no significant effect on the lubrication, which also helps in the optimization of cycloidal gear tooth profile modification, therefore, to obtain better comprehensive performance of RV reducer.